anti-Sirtuin 6 (SIRT6) 抗体

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. 再加上,我们可以发Sirtuin 6 蛋白 (20)Sirtuin 6 试剂盒 (18)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SIRT6 50721 P59941
SIRT6 51548 Q8N6T7
SIRT6 299638  
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antibodies-online.cn销售最多的anti-Sirtuin 6 抗体

Showing 10 out of 218 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 ChIP, IP, WB 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 WB 100 μL Log in to see 2至3个工作日
$229.00
详细
非结合性 ICC, IF, IHC, IHC (fro), IHC (p), IP, WB Detection of SIRT6 in MEF lysate using ABIN250952. Western Blot: SIRT6 Antibody [ABIN250952] - WB analysis of SIRT6 in NIH/3T3 cell lysate. 0.1 mL Log in to see 7至9个工作日
$444.19
详细
非结合性 IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT6 Antibody (C-term) (ABIN390181) in mouse stomach tissue lysates (35 µg/lane). SIRT6 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 EIA, IHC (p) 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 IHC (p), WB Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Mouse Cardiac Muscle Tissue Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 4至6个工作日
$280.00
详细
非结合性 ICC, IF, WB Detection of SIRT6 in HeLa whole cell lysate using ABIN250956. Immunocytochemistry/Immunofluorescence: SIRT6 Antibody [ABIN250956] - SIRT6 antibody was tested in Hela cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Log in to see 7至9个工作日
$444.19
详细
非结合性 WB SIRT6 antibody tested by Western blot. HeLa cells nuclear extract (25 μg) probed with SIRT6 antibody (1:1,000). 100 μL Log in to see 1至2个工作日
$495.83
详细
非结合性 IHC (p), WB SIRT6 Antibody (C-term) (ABIN657945) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the SIRT6 antibody detected the SIRT6 protein (arrow). 400 μL Log in to see 10至11个工作日
$324.50
详细
Biotin IHC (p), WB   100 μL Log in to see 14至21个工作日
$405.90
详细

通过反应活性、应用领域、克隆类型和共轭标记 SIRT6 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-Sirtuin 6 抗体

  1. Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250952 : Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012 (PubMed)
    Show all 11 Pubmed References

  2. Human Polyclonal SIRT6 Primary Antibody for IHC - ABIN967032 : Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal SIRT6 Primary Antibody for IHC - ABIN967033 : Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: A quantitative atlas of mitotic phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal SIRT6 Primary Antibody for ELISA - ABIN526804 : Grimley, Polyakova, Vamathevan, McKenary, Hayes, Patel, Smith, Bridges, Fosberry, Bhardwaja, Mouzon, Chung, Barrett, Richmond, Modha, Solari: Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NF?B responses. in PLoS ONE 2012 (PubMed)
    Show all 2 Pubmed References

  5. Cow (Bovine) Polyclonal SIRT6 Primary Antibody for ChIP, IP - ABIN2779624 : Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181 : Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250956 : Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012 (PubMed)

  8. Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)

  9. Human Polyclonal SIRT6 Primary Antibody for IF (p), IHC (p) - ABIN712481 : Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014 (PubMed)

更多抗Sirtuin 6的相互作用对抗体

Mouse (Murine) Sirtuin 6 (SIRT6) interaction partners

  1. Sirt6 inhibits Notch1 (显示 NOTCH1 抗体) and Notch4 (显示 NOTCH4 抗体) transcription by deacetylating histone H3K9.

  2. Sirt6 is downregulated in induced pluripotent stem cells from old mice.

  3. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (显示 PARP1 抗体)) to DNA break sites and for efficient repair of double-strand break.

  4. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

  5. These findings reveal a crucial role of SIRT6 in adipogenesis and provide potential therapeutic targets for obesity.

  6. Global and endothelium-specific SIRT6 knockout mice exhibited impaired endothelium-dependent vasorelaxation. Moreover, SIRT6(+/-) haploinsufficient mice fed a high-fat diet (HFD) also displayed impaired endothelium-dependent vasorelaxation. Importantly, SIRT6(+/-); ApoE(-/-) mice after HFD feeding had exacerbated atherosclerotic lesion development, concurrent with increased expression of proinflammatory cytokine VCAM-1.

  7. these data provide compelling evidence that Sirt6 is important for podocyte homeostasis and maintenance of glomerular function

  8. The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (显示 INS 抗体) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.

  9. Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.

  10. Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (显示 NFKB1 抗体)) and endogenous production of interleukin-6 (显示 IL6 抗体), which led to STAT3 (显示 STAT3 抗体) activation and the positive feedback circuits for NF-kappaB (显示 NFKB1 抗体) stimulation; this cross talk expedited an M1 polarization

Human Sirtuin 6 (SIRT6) interaction partners

  1. in vitro and in vivo studies showed that gene silencing of SIRT6 suppressed cell proliferation and promoted cellular apoptosis by activating the Bax (显示 BAX 抗体)-dependent apoptotic signal pathway in Hepatocellular Carcinoma cells. Furthermore, SIRT6 knockdown could increase liver cancer cell sensitivity to chemotherapy drug doxorubicin. SIRT6 is an important protumorigenic factor in liver carcinogenesis.

  2. SIRT6 is upregulated in non-small cell lung cancer; it may have a functional role in promoting migration and invasion through ERK1/2 (显示 MAPK1/3 抗体)/MMP9 (显示 MMP9 抗体) signaling

  3. Sirt6 inhibits Notch1 (显示 NOTCH1 抗体) and Notch4 (显示 NOTCH4 抗体) transcription by deacetylating histone H3K9.

  4. These data provide the first evidence of the Egt ability to interfere with endothelial senescence linked to hyperglycaemia through the regulation of SIRT1 (显示 SIRT1 抗体) and SIRT6 signaling, thus further strengthening the already assessed role of these two histone deacetylases in type 2 diabetes.

  5. Study shows that SIRT6 protein levels are lower in patients with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM) and implies that SIRT6 may take play in development T2DM by altering the expression of genes involved in glucose metabolism through histone modification rather than its role in DNA repair.

  6. Low SIRT6 expression is associated with bone marrow metastasis in neuroblastoma (显示 ARHGEF16 抗体).

  7. SIRT6 overexpression suppresses PI3K (显示 PIK3CA 抗体) signaling.

  8. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (显示 PARP1 抗体)) to DNA break sites and for efficient repair of double-strand break.

  9. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

  10. Loss- and gain-of-SIRT6 function studies in cultured human endothelial cells (ECs) showed that SIRT6 attenuated monocyte adhesion to ECs.

Cow (Bovine) Sirtuin 6 (SIRT6) interaction partners

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (显示 MAS1 抗体)) and management in beef cattle breeding programs.

Sirtuin 6 (SIRT6) 抗原简介

蛋白简介

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Sirtuin 6 (SIRT6) 抗体

  • sirtuin 6 (Sirt6) 抗体
  • sirtuin 6 (SIRT6) 抗体
  • sirtuin 6 S homeolog (sirt6.S) 抗体
  • sirtuin 6 (sirt6) 抗体
  • 2810449N18Rik 抗体
  • AI043036 抗体
  • SIR2L6 抗体
  • zgc:86729 抗体

Protein level used designations for anti-Sirtuin 6 (SIRT6) 抗体

NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6 , sirtuin (silent mating type information regulation 2 homolog) 6

GENE ID SPECIES
50721 Mus musculus
51548 Homo sapiens
299638 Rattus norvegicus
428332 Gallus gallus
535416 Bos taurus
100126274 Sus scrofa
444018 Xenopus laevis
485045 Canis lupus familiaris
100734667 Cavia porcellus
415161 Danio rerio
737026 Pan troglodytes
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