anti-Signal Peptide Peptidase-Like 2A (SPPL2A) 抗体

SPPL2A encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. 再加上,我们可以发SPPL2A 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SPPL2A 311401  
SPPL2A 84888 Q8TCT8
SPPL2A 66552 Q9JJF9
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antibodies-online.cn销售最多的anti-SPPL2A 抗体

Showing 10 out of 32 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 IHC (p), WB The anti-SPPL2a Pab (ABIN390295) is used in Western blot to detect SPPL2a in Jurkat cell lysate. Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody (N-term)(ABIN390295), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 10至11个工作日
$385.00
详细
非结合性 EIA, IHC (p), WB Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. The anti-SPPL2a Pab is used in Western blot to detect SPPL2a in Jurkat cell lysate. 0.4 mL 6至8个工作日
$484.00
详细
非结合性 WB Western blot analysis of extracts of various cell lines, using SPPL2A antibody. 200 μL 12至14个工作日
$438.90
详细
非结合性 IHC (p) Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with SPPL2A polyclonal antibody  shows strong granular cytoplasmic positivity in cells of tubules. 100 μL 11至12个工作日
$637.32
详细
小鼠 非结合性 ELISA, WB Western Blot detection against Immunogen (37 KDa) . 50 μL 11至12个工作日
$305.71
详细
PE IHC, ELISA, WB   200 μL 11至14个工作日
$1,101.83
详细
Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL 11至14个工作日
$1,101.83
详细
APC IHC, ELISA, WB   200 μL 11至14个工作日
$1,101.83
详细
Biotin IHC, ELISA, WB   200 μL 11至14个工作日
$1,101.83
详细
FITC IHC, ELISA, WB   200 μL 11至14个工作日
$1,101.83
详细

引用最多的anti-SPPL2A 抗体

  1. Human Polyclonal SPPL2A Primary Antibody for IHC (p), ELISA - ABIN545831 : Grigorenko, Moliaka, Korovaitseva, Rogaev: Novel class of polytopic proteins with domains associated with putative protease activity. in Biochemistry. Biokhimii?a 2002 (PubMed)

更多抗SPPL2A的相互作用对抗体

Human Signal Peptide Peptidase-Like 2A (SPPL2A) interaction partners

  1. inherited SPPL2a deficiency in humans underlies mycobacterial disease by decreasing the numbers of dendritic cells and impairing IFN-gamma production by mycobacterium-specific memory TH1* cells

  2. Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 by SPPL2a.

  3. In human B cells, SPPL2a is indispensable for turnover of CD74 N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a transcript and protein.

  4. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

  5. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.

  6. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  7. ADAM10 and SPPL2a were identified as two proteases implicated in FasL processing and release of the FasL intracellular domain, which has been shown to be important for retrograde FasL signaling

  8. SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 N-terminal fragment.

Mouse (Murine) Signal Peptide Peptidase-Like 2A (SPPL2A) interaction partners

  1. Sppl2a-/- mice lack conventional dendritic cells, have CD4+ T cells that produce small amounts of IFN-gamma after BCG infection, and are highly susceptible to infection with BCG or Mycobacterium tuberculosis

  2. Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 by SPPL2a.

  3. SPPL2a-mediated processing of CD74 NTF is indispensable to maintain appropriate levels of tonic BCR signaling to promote B cell maturation.

  4. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

  5. in vivo SPPL2a, but not SPPL2b, exhibit a physiologically relevant contribution to CD74 proteolysis in B and dendritic cells

  6. intramembrane proteolysis by SPPL2A is essential for maintaining cellular homeostasis of ameloblasts.

  7. Sppl2a is required for B cell and dendritic cells development and survival.

  8. Sppl2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.

  9. B cell survival and dendritic cells function requires SPPL2A.

  10. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.

SPPL2A 抗原简介

蛋白简介

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.

Gene names and symbols associated with SPPL2A

  • signal peptide peptidase-like 2A (Sppl2a) 抗体
  • signal peptide peptidase like 2A (SPPL2A) 抗体
  • signal peptide peptidase like 2A (sppl2a) 抗体
  • Signal peptide peptidase-like 2A (psl2) 抗体
  • signal peptide peptidase like 2A (Sppl2a) 抗体
  • 2010106G01Rik 抗体
  • C130089K23Rik 抗体
  • IMP3 抗体
  • LOC453430 抗体
  • LOC100231183 抗体
  • PSL2 抗体
  • RGD1563001 抗体
  • SPPL2A 抗体

Protein level used designations for SPPL2A

signal peptide peptidase-like 2A , Signal peptide peptidase-like 2A , IMP-3 , SPP-like 2A , intramembrane cleaving protease , intramembrane protease 3 , presenilin-like protein 2 , SPP-like 2A protein , protein SPPL2a

GENE ID SPECIES
311401 Rattus norvegicus
415450 Gallus gallus
453430 Pan troglodytes
100135083 Xenopus (Silurana) tropicalis
100231183 Taeniopygia guttata
100348259 Oryctolagus cuniculus
100380541 Salmo salar
84888 Homo sapiens
66552 Mus musculus
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