Shadow of Prion Protein Homolog (Zebrafish) 蛋白 (SPRN)

Prion-like protein that has PrP(C)-like neuroprotective activity. 再加上,我们可以发SPRN 抗体 (41)SPRN 试剂盒 (1)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
SPRN 212518 Q8BWU1
SPRN 503542 Q5BIV9
SPRN 541462 Q5BIV7
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,465.26
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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酵母菌 小鸡 His tag   1 mg Log in to see 60至71个工作日
$2,113.83
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酵母菌 斑马鱼 His tag   1 mg Log in to see 60至71个工作日
$2,123.00
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酵母菌 Xenopus tropicalis His tag   1 mg Log in to see 60至71个工作日
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酵母菌 绵羊 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
$2,168.83
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酵母菌 Three-spined Stickleback (Gasterosteus aculeatus) His tag   1 mg Log in to see 60至71个工作日
$2,168.83
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SPRN 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human

Rat (Rattus)

更多Shadow of Prion Protein Homolog (Zebrafish) (SPRN)互动伙伴

Mouse (Murine) Shadow of Prion Protein Homolog (Zebrafish) (SPRN) interaction partners

  1. Data suggest that expression of shadoo in neuron or hepatocyte cell lines induces same toxic phenotype of drug hypersensitivity as prion protein/PrP (显示 PRNP 蛋白)(-central region); this effect is counteracted by co-expression of PrP-wild-type.

  2. No significant differences in survival, the incubation period of prion (显示 PRNP 蛋白) disease or other disease features were observed between Sho mutant and WT mice

  3. These observations suggest that Shadoo can affect the prion (显示 PRNP 蛋白) replication process by (i) acting as a holdase and (ii) interfering with the dominant-negative inhibitor effect of the C1 fragment.

  4. Data suggest that glycosylation status of the prion protein (显示 PRNP 蛋白) and yet-to-be-dentified proteases modulate internal C1 and C2 endoproteolysis of Shadoo (shadow of prion protein) and Doppel (doppelganger (显示 PRND 蛋白) prion (显示 PRNP 蛋白)) in mouse neurons.

  5. binding of Sho to anionic liposomes has disruptive effect on integrity of lipid bilayer leading to formation of supramolecular lipid-protein complexes. prion (显示 PRNP 蛋白) diseases might depend on the oligomerization state of Sho and on these lipoprotein assembles.

  6. Sho is not pi, or, given the accumulating data for many activities for PrP (C (显示 PRNP 蛋白)) , the pi hypothesis invoking a discrete signaling pathway to maintain neuronal viability is no longer tenable.

  7. Here we report that Shadoo (Sho)-a member of the prion protein (显示 PRNP 蛋白) superfamily-is also found in the nucleus of several neural and non-neural cell lines as visualized by using an YFP-Sho construct

  8. the Sho region N-terminal to the hydrophobic domain includes tandem positively charged "RGG boxes", predicted to bind RNA. Here, we demonstrate that Sho binds DNA and RNA in vitro via this arginine-rich region.

  9. using various Prnp (显示 PRNP 蛋白) transgenic mouse lines and lentiviral vectors expressing shRNAs that target the Shadoo-encoding mRNA, we further demonstrate the specific requirement of at least one of these two PrP-related proteins at early developmental stages

  10. Knockout of the prion protein (PrP (显示 PRNP 蛋白))-like Sprn gene does not produce embryonic lethality in combination with PrP(C (显示 PRNP 蛋白))-deficiency.

Human Shadow of Prion Protein Homolog (Zebrafish) (SPRN) interaction partners

  1. Shadoo is degraded in Scrapie-infected rodents and cultured cells mediated by proteasome degradation after modification by ubiquitination.

  2. a conserved physiological activity between PrP(C (显示 PRNP 蛋白)) and Sho to protect cells from stress-induced toxicity and suggests that Sho and PrP(C (显示 PRNP 蛋白)) might act on similar signaling pathways.

  3. A novel solid phase technology for high- throughput synthesis of the SPRN gene is reported.

  4. Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease

Cow (Bovine) Shadow of Prion Protein Homolog (Zebrafish) (SPRN) interaction partners

  1. Genetic characterization of PRNP (显示 PRNP 蛋白) promoter indel variations and the polymorphism of open reading frames (ORFs) of PRNP (显示 PRNP 蛋白) and bovine prion (显示 PRNP 蛋白)-like Shadoo (SPRN) genes, are reported.

  2. Sho as a non-PrP (显示 PRNP 蛋白) specific marker for prion (显示 PRNP 蛋白) infections, with obex as the best tissue source for the detection of Sho in transmissible spongiform encephalopathies rapid tests.

  3. SPRN has the typical two-exon PRNP (显示 PRNP 蛋白) arrangement, with the CDS (显示 ABHD5 蛋白) fully contained within exon 2; furthermore, it codes for a 143-amino-acid protein with 74.8% identity and 84.7% similarity with the human PRNP (显示 PRNP 蛋白).

蛋白简介SPRN

蛋白简介

Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).

Gene names and symbols associated with SPRN

  • shadow of prion protein (Sprn)
  • shadow of prion protein (sprn)
  • shadow of prion protein (SPRN)
  • bA108K14.1 蛋白
  • C630041J07 蛋白
  • p12 蛋白
  • SHADOO 蛋白
  • SHO 蛋白
  • Sho1 蛋白
  • sprna 蛋白

Protein level used designations for SPRN

Shadoo , protein shadoo , shadoo , shadow of prion protein 1 , hypothetical protein BC004409 , shadow of prion protein , shadoo protein Sho

GENE ID SPECIES
212518 Mus musculus
386702 Danio rerio
503542 Homo sapiens
541462 Rattus norvegicus
616266 Bos taurus
100302330 Ovis aries
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