anti-Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) 抗体

The protein encoded by SEL1L is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner.

列出全部抗体 基因 基因ID UniProt
 SEL1L SEL1L 6400 Q9UBV2
小鼠 SEL1L SEL1L 20338 Q9Z2G6
大鼠 SEL1L SEL1L 314352 Q80Z70
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antibodies-online.cn销售最多的anti-SEL1L 抗体

Showing 10 out of 87 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
山羊 非结合性 ELISA, WB ABIN263220 (1µg/ml) staining of HepG2 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$358.02
详细
非结合性 FACS, IHC (p), WB SEL1L Antibody (Center) (ABIN654642) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 EIA, FACS, IHC (p), WB Flow cytometric analysis of MCF-7 cells using SEL1L Antibody (Center) Cat.-No AP53837PU-N (Right histogram) compared to a negative control cell (Left histogram). FITC-conjugated Goat-anti-Rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human pancreas tissue stained with SEL1L antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SEL1L antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 EIA, WB Western blot analysis of SEL1L Antibody (N-term) Cat.-No AP53838PU-N in T47D cell line lysates (35ug/lane). This demonstrates the SEL1L antibody detected the SEL1L protein (arrow). 0.4 mL Log in to see 6至8个工作日
$390.50
详细
Bat 山羊 非结合性 ELISA, WB 100 μg Log in to see 7至9个工作日
$610.50
详细
山羊 非结合性 EIA, WB   0.1 mg Log in to see 8至11个工作日
$462.00
详细
小鼠 非结合性 IHC, IHC (fro), IHC (p), IP, WB Human Pancreas (formalin-fixed, paraffin-embedded) stained with SEL1L antibody ABIN334261 at 2.5-5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7至9个工作日
$727.83
详细
非结合性 WB SEL1L Antibody (N-term)  western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the SEL1L antibody detected the SEL1L protein (arrow). 400 μL Log in to see 10至11个工作日
$324.50
详细
山羊 非结合性 ELISA, WB Western Blot: SEL1L Antibody [ABIN4087183] - (1ug/ml) staining of HepG2 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7至9个工作日
$485.88
详细
非结合性 FACS, IHC (p), WB Western blot analysis in MCF-7 cell line lysates (35ug/lane). SEL1L antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 2至3个工作日
$515.63
详细

引用最多的anti-SEL1L 抗体

  1. Human Polyclonal SEL1L Primary Antibody for ELISA, WB - ABIN408718 : Schelhaas, Malmström, Pelkmans, Haugstetter, Ellgaard, Grünewald, Helenius: Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. in Cell 2007 (PubMed)

更多抗SEL1L的相互作用对抗体

Human Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) interaction partners

  1. The SEL1L critically regulates HRD1 (显示 SYVN1 抗体)-mediated disposal of misfolded cargo through its short membrane spanning stretch.

  2. this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients

  3. Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma.

  4. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin (显示 INS 抗体) signalling to create a favourable micro-environment for ss-cell development and function.

  5. SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties.

  6. ATF6 (显示 ATF6 抗体) represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature.

  7. ERdj5 (显示 DNAJC10 抗体), by binding to Sel1L, triggers BiP (显示 GDF10 抗体)-Cholera toxin interaction proximal to the Hrd1 (显示 SYVN1 抗体) complex; postulate this scenario enables the Hrd1 (显示 SYVN1 抗体)-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP (显示 GDF10 抗体)

  8. SEL1L expression is a potential colorectal cancer (CRC (显示 CALR 抗体)) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC (显示 CALR 抗体) cancers

  9. the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers.

  10. Two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells.

Mouse (Murine) Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) interaction partners

  1. This study implicates Endoplasmic reticulum (ER)-associated degradation mediated by Sel1L-Hrd1 (显示 SYVN1 抗体) as a key regulator of B cell development.

  2. Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus

  3. The authors propose that certain Sel1-Like Repeat motifs of SEL1L play a unique role in membrane bound ERAD machinery.

  4. Sel1L-Hrd1 (显示 SYVN1 抗体) plays a constitutive role in endoplasmic reticulum associated degradation in epithelial cell biology and the pathogenesis of intestinal inflammation in Crohn's disease.

  5. Data show that inositol requiring enzyme 1alpha (IRE1alpha (显示 ERN1 抗体)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L proten-Hrd1 protein (显示 SYVN1 抗体) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  6. Adipocyte-specific Sel1L-deficient (AKO) mice are resistant to diet-induced obesity. Sel1L stabilizes and prevents LPL (显示 LPL 抗体) dimers from aggregation in the endoplasmic reticulum.

  7. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin (显示 INS 抗体) signalling to create a favourable micro-environment for ss-cell development and function.

  8. Sel1L is an indispensable component of the mammalian Hrd1 (显示 SYVN1 抗体) endoplasmic reticulum-associated degradation and endoplasmic reticulum homeostasis.

  9. a critical and previously unknown function for SEL1L in regulating adult beta-cell function and growth

  10. an essential role for SEL1L in protein quality control during mouse embryonic development.

SEL1L 抗原简介

蛋白简介

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SEL1L

  • SEL1L ERAD E3 ligase adaptor subunit (SEL1L) 抗体
  • sel-1 suppressor of lin-12-like (C. elegans) (Sel1l) 抗体
  • SEL1L ERAD E3 ligase adaptor subunit (Sel1l) 抗体
  • sel-1 suppressor of lin-12-like L homeolog (sel1l.L) 抗体
  • sel-1 suppressor of lin-12-like (C. elegans) (SEL1L) 抗体
  • sel-1 suppressor of lin-12-like (sel1l) 抗体
  • AW493766 抗体
  • MGC99195 抗体
  • mKIAA4137 抗体
  • PRO1063 抗体
  • Sel-1L 抗体
  • SEL1-LIKE 抗体
  • Sel1h 抗体
  • SEL1L 抗体
  • SEL1L1 抗体

Protein level used designations for SEL1L

Suppressor of lin 12 (sel-1), C. elegans, homolog of , protein sel-1 homolog 1 , sel-1 suppressor of lin-12-like 1 , suppressor of lin-12-like protein 1 , Sel1 (suppressor of lin-12) 1 homolog , sel-1L , sel-1 suppressor of lin-12-like (C. elegans) , sel-1 suppressor of lin-12-like , protein sel-1 homolog 1-like , Suppressor of lin-12-like protein 1

GENE ID SPECIES
6400 Homo sapiens
20338 Mus musculus
314352 Rattus norvegicus
423391 Gallus gallus
453080 Pan troglodytes
480409 Canis lupus familiaris
614959 Bos taurus
708651 Macaca mulatta
735099 Xenopus laevis
100052711 Equus caballus
100155424 Sus scrofa
100231514 Taeniopygia guttata
100353303 Oryctolagus cuniculus
100377925 Saccoglossus kowalevskii
100380038 Xenopus (Silurana) tropicalis
100408799 Callithrix jacchus
100477463 Ailuropoda melanoleuca
100548852 Meleagris gallopavo
100583688 Nomascus leucogenys
101834260 Mesocricetus auratus
100730201 Cavia porcellus
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