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The protein encoded by SEL1L is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner.
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Human Polyclonal SEL1L Primary Antibody for ELISA, WB - ABIN408718
Schelhaas, Malmström, Pelkmans, Haugstetter, Ellgaard, Grünewald, Helenius: Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. in Cell 2007
The SEL1L critically regulates HRD1 (显示 SYVN1 抗体)-mediated disposal of misfolded cargo through its short membrane spanning stretch.
this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients
Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma.
Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin (显示 INS 抗体) signalling to create a favourable micro-environment for ss-cell development and function.
SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties.
ATF6 (显示 ATF6 抗体) represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature.
ERdj5 (显示 DNAJC10 抗体), by binding to Sel1L, triggers BiP (显示 GDF10 抗体)-Cholera toxin interaction proximal to the Hrd1 (显示 SYVN1 抗体) complex; postulate this scenario enables the Hrd1 (显示 SYVN1 抗体)-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP (显示 GDF10 抗体)
SEL1L expression is a potential colorectal cancer (CRC (显示 CALR 抗体)) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC (显示 CALR 抗体) cancers
the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers.
Two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells.
This study implicates Endoplasmic reticulum (ER)-associated degradation mediated by Sel1L-Hrd1 (显示 SYVN1 抗体) as a key regulator of B cell development.
Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus
The authors propose that certain Sel1-Like Repeat motifs of SEL1L play a unique role in membrane bound ERAD machinery.
Sel1L-Hrd1 (显示 SYVN1 抗体) plays a constitutive role in endoplasmic reticulum associated degradation in epithelial cell biology and the pathogenesis of intestinal inflammation in Crohn's disease.
Data show that inositol requiring enzyme 1alpha (IRE1alpha (显示 ERN1 抗体)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L proten-Hrd1 protein (显示 SYVN1 抗体) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.
Adipocyte-specific Sel1L-deficient (AKO) mice are resistant to diet-induced obesity. Sel1L stabilizes and prevents LPL (显示 LPL 抗体) dimers from aggregation in the endoplasmic reticulum.
Sel1L is an indispensable component of the mammalian Hrd1 (显示 SYVN1 抗体) endoplasmic reticulum-associated degradation and endoplasmic reticulum homeostasis.
a critical and previously unknown function for SEL1L in regulating adult beta-cell function and growth
an essential role for SEL1L in protein quality control during mouse embryonic development.
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Suppressor of lin 12 (sel-1), C. elegans, homolog of
, protein sel-1 homolog 1
, sel-1 suppressor of lin-12-like 1
, suppressor of lin-12-like protein 1
, Sel1 (suppressor of lin-12) 1 homolog
, sel-1 suppressor of lin-12-like (C. elegans)
, sel-1 suppressor of lin-12-like
, protein sel-1 homolog 1-like
, Suppressor of lin-12-like protein 1