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The protein encoded by SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. 再加上，我们可以发SLAMF6 抗体 (90) 和 SLAMF6 蛋白 (20)和数多这个蛋白质的别的产品。
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in addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
our data reveal how SAP (显示 APCS ELISA试剂盒) nucleates a previously unknown signaling complex involving NTB-A and LCK (显示 LCK ELISA试剂盒) to potentiate restimulation-induced cell death of activated human T cells.
Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.
Data indicate that the dominance of the SLAMF3 (显示 LY9 ELISA试剂盒)/SLAMF6 pathway in inducing IL-17A (显示 IL17A ELISA试剂盒) production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A (显示 IL17A ELISA试剂盒) promoter.
SLAMF3 (显示 LY9 ELISA试剂盒) and SLAMF6 T cell surface expression and IL-17 (显示 IL17A ELISA试剂盒) levels significantly correlate with disease activity in systemic lupus erythematosus patients
Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 (显示 TH1L ELISA试剂盒) and IL-2 (显示 IL2 ELISA试剂盒) cytokine production
Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells.
regulation of interferon-gamma (显示 IFNG ELISA试剂盒) secretion, and not interleukin-4 (显示 IL4 ELISA试剂盒) in vitro, as well as inhibition of Th1 (显示 TH1L ELISA试剂盒) cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response
NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.
naive T cells regulate B cell survival in a SLAMF6-dependent manner
in addition to its established role in Invariant NKT (显示 CTSL1 ELISA试剂盒)(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans
CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT (显示 CTSL1 ELISA试剂盒) Cell Defects but Not T Follicular Helper Cell Defects.
study establishes a central role for germinal center B cell-specific CD84 (显示 CD84 ELISA试剂盒) and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity
When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta (显示 CD247 ELISA试剂盒) interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta (显示 CD247 ELISA试剂盒) dephosphorylation.
Ly108 expression distinguishes subsets of invariant NKT (显示 CTSL1 ELISA试剂盒) cells that help autoantibody production and secrete IL-21 (显示 IL21 ELISA试剂盒) from those that secrete IL-17 (显示 IL17A ELISA试剂盒) in lupus prone NZB/W mice.
Data indicate that Slamf6-H1 suppresses the spontaneous expansion of a unique osteopontin OPN (显示 SPP1 ELISA试剂盒)+ T follicular helper (TFH) cells.
Ly108 plays a role in the induction of PLZF in developing thymocytes.
In the absence of SAP (显示 APCS ELISA试剂盒), signaling through the SLAM (显示 SLAMF1 ELISA试剂盒) family members Ly108 and 2B4 (显示 CD244 ELISA试剂盒) resulted in increased recruitment of the SHP-1 (显示 PTPN6 ELISA试剂盒) phosphatase, associated with altered SHP-1 (显示 PTPN6 ELISA试剂盒) localization and decreased activation of Src (显示 SRC ELISA试剂盒) kinases at the synapse.
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
SLAM family member 6
, activating NK receptor
, NTBA receptor
, natural killer-, T- and B-cell antigen
, lymphocyte antigen 108