SET Domain, Bifurcated 1 蛋白 (SETDB1)

SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. 再加上,我们可以发SETDB1 抗体 (112)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
大鼠 SETDB1 SETDB1 689883  
SETDB1 9869 Q15047
SETDB1 84505  
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$414.29
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Baculovirus DYKDDDDK Tag Recombinant SETDB1 protein gel. SETDB1 protein was run on an SDS-PAGE gel and stained with Coomassie blue. SETDB1 activity assay. HMT assay measuring the activity of Recombinant SETDB1. Activity was detected by fluorography. 20 μg Log in to see 1至2个工作日
$495.83
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SETDB1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, , ,
Mouse (Murine)

更多SET Domain, Bifurcated 1 (SETDB1)互动伙伴

Cow (Bovine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.

Pig (Porcine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. observations suggested that SET domain bifurcated 1 histone-lysine N-methyltransferase (SETDB1) is a novel epigenetic regulator of porcine male germ cells, and contributes to the maintenance of gonocyte survival in pigs

Human SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. Increased expression of SETDB1 may predict poor overall survival.

  2. SETDB1 is enriched at H3K9me3 regions and K9me3/K14ac is enriched at SETDB1 binding sites overlapping with LINE elements, suggesting that recruitment of the SETDB1 complex to K14ac/K9me regions has a role in silencing of active genomic regions.

  3. We identified a list of thirty genes repressed by DeltaNp63 in a SETDB1-dependent manner, whose expression is positively correlated to survival of breast cancer patients. These results suggest that p63 (显示 RPE65 蛋白) and SETDB1 expression, together with the repressed genes, may have diagnostic and prognostic potential

  4. these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 abundance in the nucleus.

  5. SETDB1 triggers silencing of retrotransposons to inhibit the interferon (显示 IFNA 蛋白) response in acute myeloid leukemia (显示 BCL11A 蛋白) cells.

  6. analysis of a 1q21.3 deletion encompassing SETDB1 that provides further support for the role of chromatin modifiers in the etiology of autism spectrum disorder

  7. SETDB1 protein expression was significantly associated with poor survival and was related to TNM (显示 ODZ1 蛋白) stage.

  8. SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain. This ubiquitination is directly catalyzed by UBE2E family of E2 enzymes in an E3-independent manner while the conjugated-ubiquitin (Ub) is protected from active deubiquitination.

  9. These results suggest that the ubiquitination of SETDB1 at lysine 867 controls the expression of its target gene by activating its H3K9 methyltransferase activity.

  10. Authors observed several complementary mechanisms contributing to the upregulation of SETDB1 in HCC (显示 FAM126A 蛋白) cells. Besides copy number gains at the SETDB1 gene locus at chromosome 1q21 enhanced SETDB1 transcription mediated by the transcription factor SP1 (显示 SP1 蛋白) could be detected.

Mouse (Murine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1

  2. Results demonstrate a novel and unexpected role for SETDB1 in protecting IAPs from TET2-dependent histone arginine demethylation.

  3. Data show that SET domain bifurcated 1 histone-lysine N-methyltransferase (Setdb1) in macrophages suppresses Toll-like receptor 4 (TLR4 (显示 TLR4 蛋白))-mediated expression of proinflammatory cytokines.

  4. Results identify Setdb1 as a paternal effect gene in the mouse and suggest that epigenetic inheritance may be more likely in individuals with altered levels of epigenetic modifiers.

  5. Setdb1 regulates PTEN/AKT (显示 AKT1 蛋白)/FOXO1 (显示 FOXO1 蛋白) pathway to inhibit Spermatogonial stem cells apoptosis.

  6. the SETDB1 repressor complex shields neuronal genomes from excess CTCF (显示 CTCF 蛋白) genome organizer binding and is critically required for structural maintenance of the protocadherin locus topologically associated domain

  7. The results identify Setdb1 as a newly discovered meiotic and embryonic competence factor safeguarding genome integrity at the onset of life.

  8. SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain. This ubiquitination is directly catalyzed by UBE2E family of E2 enzymes in an E3-independent manner while the conjugated-ubiquitin (Ub) is protected from active deubiquitination.

  9. study identifed ESET as first trimethylated H3K9 histone methyltransferase playing a crucial role in T cell development

  10. Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.

蛋白简介SETDB1

蛋白简介

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.

Gene names and symbols associated with SETDB1

  • SET domain, bifurcated 1 (Setdb1)
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (MLLT11)
  • SET domain bifurcated 1 (SETDB1)
  • histone-lysine N-methyltransferase SETDB1 (LOC100120014)
  • histone-lysine N-methyltransferase SETDB1 (LOC100461671)
  • SET domain, bifurcated 1a (setdb1a)
  • SET domain bifurcated 1 L homeolog (setdb1.L)
  • AU022152 蛋白
  • ESET 蛋白
  • fc07d03 蛋白
  • H3-K9-HMTase4 蛋白
  • KG1T 蛋白
  • KMT1E 蛋白
  • mKIAA0067 蛋白
  • NV10069 蛋白
  • SETDB1 蛋白
  • si:ch211-81a5.6 蛋白
  • TDRD21 蛋白
  • wu:fc07d03 蛋白

Protein level used designations for SETDB1

histone-lysine N-methyltransferase SETDB1 , SET domain, bifurcated 1 , histone-lysine N-methyltransferase SETDB1-like , histone-lysine N-methyltransferase SETDB1-A , ERG-associated protein with SET domain , ERG-associated protein with a SET domain, ESET , H3-K9-HMTase 4 , histone H3-K9 methyltransferase 4 , histone-lysine N-methyltransferase, H3lysine-9 specific 4 , lysine N-methyltransferase 1E , tudor domain containing 21 , SET domain ERG-associated histone methyltransferase

GENE ID SPECIES
689883 Rattus norvegicus
395847 Gallus gallus
469481 Pan troglodytes
716141 Macaca mulatta
100120014 Nasonia vitripennis
100138100 Bos taurus
100157920 Sus scrofa
100411734 Callithrix jacchus
100461671 Pongo abelii
100482250 Ailuropoda melanoleuca
553292 Danio rerio
9869 Homo sapiens
84505 Mus musculus
432147 Xenopus laevis
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