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SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. 再加上，我们可以发SETDB1 抗体 (112) 和 和数多这个蛋白质的别的产品。
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SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.
observations suggested that SET domain bifurcated 1 histone-lysine N-methyltransferase (SETDB1) is a novel epigenetic regulator of porcine male germ cells, and contributes to the maintenance of gonocyte survival in pigs
Increased expression of SETDB1 may predict poor overall survival.
SETDB1 is enriched at H3K9me3 regions and K9me3/K14ac is enriched at SETDB1 binding sites overlapping with LINE elements, suggesting that recruitment of the SETDB1 complex to K14ac/K9me regions has a role in silencing of active genomic regions.
We identified a list of thirty genes repressed by DeltaNp63 in a SETDB1-dependent manner, whose expression is positively correlated to survival of breast cancer patients. These results suggest that p63 (显示 RPE65 蛋白) and SETDB1 expression, together with the repressed genes, may have diagnostic and prognostic potential
these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 abundance in the nucleus.
SETDB1 triggers silencing of retrotransposons to inhibit the interferon (显示 IFNA 蛋白) response in acute myeloid leukemia (显示 BCL11A 蛋白) cells.
analysis of a 1q21.3 deletion encompassing SETDB1 that provides further support for the role of chromatin modifiers in the etiology of autism spectrum disorder
SETDB1 protein expression was significantly associated with poor survival and was related to TNM (显示 ODZ1 蛋白) stage.
SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain. This ubiquitination is directly catalyzed by UBE2E family of E2 enzymes in an E3-independent manner while the conjugated-ubiquitin (Ub) is protected from active deubiquitination.
These results suggest that the ubiquitination of SETDB1 at lysine 867 controls the expression of its target gene by activating its H3K9 methyltransferase activity.
Authors observed several complementary mechanisms contributing to the upregulation of SETDB1 in HCC (显示 FAM126A 蛋白) cells. Besides copy number gains at the SETDB1 gene locus at chromosome 1q21 enhanced SETDB1 transcription mediated by the transcription factor SP1 (显示 SP1 蛋白) could be detected.
We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1
Results demonstrate a novel and unexpected role for SETDB1 in protecting IAPs from TET2-dependent histone arginine demethylation.
Data show that SET domain bifurcated 1 histone-lysine N-methyltransferase (Setdb1) in macrophages suppresses Toll-like receptor 4 (TLR4 (显示 TLR4 蛋白))-mediated expression of proinflammatory cytokines.
Results identify Setdb1 as a paternal effect gene in the mouse and suggest that epigenetic inheritance may be more likely in individuals with altered levels of epigenetic modifiers.
Setdb1 regulates PTEN/AKT (显示 AKT1 蛋白)/FOXO1 (显示 FOXO1 蛋白) pathway to inhibit Spermatogonial stem cells apoptosis.
the SETDB1 repressor complex shields neuronal genomes from excess CTCF (显示 CTCF 蛋白) genome organizer binding and is critically required for structural maintenance of the protocadherin locus topologically associated domain
The results identify Setdb1 as a newly discovered meiotic and embryonic competence factor safeguarding genome integrity at the onset of life.
study identifed ESET as first trimethylated H3K9 histone methyltransferase playing a crucial role in T cell development
Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
histone-lysine N-methyltransferase SETDB1
, SET domain, bifurcated 1
, histone-lysine N-methyltransferase SETDB1-like
, histone-lysine N-methyltransferase SETDB1-A
, ERG-associated protein with SET domain
, ERG-associated protein with a SET domain, ESET
, H3-K9-HMTase 4
, histone H3-K9 methyltransferase 4
, histone-lysine N-methyltransferase, H3lysine-9 specific 4
, lysine N-methyltransferase 1E
, tudor domain containing 21
, SET domain ERG-associated histone methyltransferase