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The protein encoded by S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.
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S100A2 and S100P (显示 S100P 抗体) can be used as specific duct markers in eccrine sweat glands, and combined use of S100P (显示 S100P 抗体) or S100A2 with keratins enables easy to distinction between secretory coils and ducts.
These results indicate that oxidative stress impairs the ability of S100 proteins to bind and activate PP5 (显示 PPP5C 抗体), which in turn modulates the ASK1 (显示 MAP3K5 抗体)-mediated signaling cascades involved in apoptosis.
high S100A2 expression and NSCLC
Our results indicate that serum levels of S100A2 and S100A6 (显示 S100A6 抗体) are significantly elevated in early stage non-small cell lung cancer
S100A2 could have a role in poor prognosis in stage II and III colorectal cancer recurrence
The potential of cytoplasmic S100A2 overexpression as a predictor of recurrence risk in oral squamous cell carcinoma patients.
Data show higher expression level of S100A2 in high-invasive cholangiocarcinoma Cell Line suggesting it as potential marker of tumor progression and novel therapeutic target.
Our investigation complements the current understanding of laryngeal cancer progression. Furthermore, this study supports the concept that enhanced expression of S100A2 may be a promising strategy in developing novel cancer therapeutic drugs.
These data demonstrate the importance of S100A2 downstream of the BRCA1/DeltaNp63 signalling axis in modulating transcriptional responses and enforcing growth control mechanisms through destabilisation of mutant p53 (显示 TP53 抗体).
loss of S100A2 expression contributes to Ggastric cancer development and progression.
S100A2 and S100A6 (显示 S100A6 抗体) interact with another TPR (显示 GRID2 抗体) protein Tom70 (显示 TOMM70A 抗体) and regulate the Tom70 (显示 TOMM70A 抗体)-ligand interaction in vitro
Survival after UVA irradiation was greater in human keratinocytes compared to mouse skin with no S100A2 expression, showing a protective role for S100A2. A S100A2-dependent difference was observed in the induction of Cxcl13 (显示 CXCL13 抗体) transcripts in transgenic mice.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer.
S100 calcium binding protein A2
, S100 calcium-binding protein A2
, protein S100-A2
, predicted gene, EG628324