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RBBP5 encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins.
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Human Polyclonal RBBP5 Primary Antibody for ChIP, ICC - ABIN153192
Wysocka, Swigut, Milne, Dou, Zhang, Burlingame, Roeder, Brivanlou, Allis: WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. in Cell 2005
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this study shows that during epithelial-mesenchymal transition in the prostate cancer cell line RbBP5 binding is increased in the vicinity of Snail (显示 SNAI1 抗体) transcription start site
role of RBQ3 in the development of multiple myeloma
This study demonstrated that RBQ3 might play an important role in glioma, and RBQ3 inhibitors might be novel anti-tumor agents.
The identified components revealed factors involved in histone methylation and cell cycle control and include Ash2L (显示 ASH2L 抗体), RbBP5, WDR5 (显示 WDR5 抗体), HCF-1 (显示 HCFC1 抗体), DBC-1, and EMSY (显示 C11orf30 抗体).
Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5/Ash2L (显示 ASH2L 抗体) heterodimer.
Data indicate that MLL1 methylates Ash2L (显示 ASH2L 抗体) in the absence of histone H3 (显示 HIST3H3 抗体), but only when assembled within a complex with WDR5 (显示 WDR5 抗体) and RbBP5.
structural and biochemical analyses reveal a basic surface on Ash2L (显示 ASH2L 抗体) as the RbBP5-binding interface, and this interface is crucial for both RbBP5 binding and MLL1 methyltransferase activity regulation
Results show that Depletion of CHD8 (显示 CHD8 抗体) enhances HOXA2 (显示 HOXA2 抗体) expression and a loss of the WDR5 (显示 WDR5 抗体)/Ash2L (显示 ASH2L 抗体)/RbBP5 subcomplex.
analysis of menin's role as a tumor suppressor and binding sites of Rbbp5 and MLL1
a phosphorylation switch on RbBP5 stimulates WRAD complex formation and significantly increases KMT2 (lysine [K] methyltransferase 2 (显示 DNMT1 抗体)) enzyme methylation rates
Characterization of a novel WDR5 (显示 WDR5 抗体)-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 (显示 HIST3H3 抗体) lysine 4 by mixed lineage leukemia protein-1.
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
retinoblastoma binding protein 5
, retinoblastoma-binding protein 5-like
, SWD1, Set1c WD40 repeat protein, homolog
, retinoblastoma-binding protein 5
, retinoblastoma-binding protein RBQ-3