Use your antibodies-online credentials, if available.
The protein encoded by RACGAP1 belongs to the GTPase-activating protein (GAP) family. 再加上，我们可以发RACGAP1 试剂盒 (22) 和 RACGAP1 蛋白 (7)和数多这个蛋白质的别的产品。
Showing 10 out of 126 products:
Human Monoclonal RACGAP1 Primary Antibody for ELISA, WB - ABIN565414
Wolfe, Takaki, Petronczki, Glotzer: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. in PLoS biology 2009
Show all 4 Pubmed References
Human Polyclonal RACGAP1 Primary Antibody for IHC (p), IHC - ABIN257840
Reibel, Dorseuil, Stancou, Bertoglio, Gacon: A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation. in Biochemical and biophysical research communications 1991
Study showed that a subset of epithelial ovarian cancer (EOC) patients have RacGAP1 overexpression which is associated with advanced tumor stages and poor clinical outcomes. Also, RacGAP1 can positively regulate the activation of RhoA (显示 RHOA 抗体) and Erk (显示 EPHB2 抗体) proteins, thus up-enhance the migration and invasion process of EOC.
Data show that comparing with Ki-67 (显示 MKI67 抗体) and TOP2A (显示 TOP2A 抗体), RacGAP1 allowed for a clearer prognostic statement.
RACGAP1 promotes the metastatic phenotype in uterine carcinosarcoma via a STAT3 (显示 STAT3 抗体)/survivin (显示 BIRC5 抗体) signaling pathway.
High RACGAP1 expression is associated with Basal-like Breast Cancers.
Data suggest that MGCRABGAP (显示 TBC1D21 抗体) is involved in mammalian spermiogenesis by modulating RAB10 (显示 RAB10 抗体).
This study showed that the overexpressions of Ki67 (显示 MKI67 抗体), RacGAP1, and TOP2a (显示 TOP2A 抗体) affect the prognosis of female breast cancer patients adversely
Data confirmed a strong correlation of AURKA (显示 AURKA 抗体) and Wnt (显示 WNT2 抗体)-modulator RACGAP1 gene expression both in the gastric tumor, the tumor-adjacent and the tumor-distant mucosa.
RacGAP1 Is a Novel Downstream Effector of E2F7 (显示 E2F7 抗体)-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma
RACGAP1 expression levels in the nucleus and cytoplasm, determined by immunohistochemical staining, predict opposite clinical outcomes and that both could be independent prognostic markers for colorectal cancer.
central spindle assembly and 2 Plk1 (显示 PLK1 抗体)-dependent phosphorylations are required to establish efficient binding of the Ect2 (显示 ECT2 抗体) BRCT in early cytokinesis.
Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
APC (显示 APC 抗体)(CDH1 (显示 CDH1 抗体)) targets MgcRacGAP for destruction in the late M phase.
TLR4 (显示 TLR4 抗体) signaling shapes B cell dynamics via MyD88 (显示 MYD88 抗体)-dependent pathways and Rac (显示 AKT1 抗体) GTPases.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (显示 AKT1 抗体), CDC42 (显示 CDC42 抗体), and RhoG small GTPase activities
Rac regulates vascular endothelial growth factor stimulated motility
These results indicate that MgcRacGAP regulates cytokinesis and cellular differentiation as a regulator of Rho family of GTPase and suggest that this process is controlled by some serine/threonine kinases.
alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase (显示 PIK3CA 抗体)-Cdc42 (显示 CDC42 抗体)/Rac (显示 AKT1 抗体) pathways may play a role in determining the size and shape of tooth germ
Gab2 (显示 GAB2 抗体) via Shp-2 (显示 PTPN11 抗体) is critical for transmitting signals from Kit Tyr (显示 TYR 抗体)(567) to activate the Rac (显示 AKT1 抗体)/JNK (显示 MAPK8 抗体) pathway controlling mast cell proliferation
Data demonstrate that normal cytokinesis in B lymphocytes requires the GAP and NH2 terminal domains but not GAP activity of mgcRacGAP.
Rac (显示 AKT1 抗体) became activated within 2 min after peripheral membrane extensions adhered to new ECM (显示 MMRN1 抗体) islands, and this activation wave propagated outward in an oriented manner as the cells spread from island to island
In vivo cell recordings reveal that gradual loss of wild-type RacGAP1 leads progressively from a failure of abscission, then to cleavage furrow ingression, and finally complete absence of furrow formation. Despite the lack of cytokinesis, gross patterning occurs overtly normally in ogre mutants and cells continue to cycle slowly, some even attaining four or eight nuclei.
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
Rac GTPase activating protein 1
, rac GTPase-activating protein 1-like
, GTPase activating protein
, male germ cell RacGap
, protein CYK4 homolg
, protein CYK4 homolog
, rac GTPase-activating protein 1
, Rac GTPase-activating protein 1