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The protein encoded by RAB2A belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis.
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Human Polyclonal RAB2A Primary Antibody for WB - ABIN262447
Tisdale, Balch: Rab2 is essential for the maturation of pre-Golgi intermediates. in The Journal of biological chemistry 1997
S100A7 (显示 S100A7 抗体) affects cell motility and invasion by regulating the RAB2A-associated MAPK (显示 MAPK1 抗体) signaling cascades.
Identify Rab2 as a key factor for autophagic and endocytic cargo delivery to and degradation in lysosomes.
our data reveal that RAB2A is new critical membrane trafficking players in the regulation of mesenchymal properties of normal and tumorigenic cells and a critical determinant of an invasive, proteolytic mode of BC progression.
RAB2A variance has effect on the structure and function of the PFC (显示 CFP 抗体) and related cognitive functions.
This study demonstrated that RAB2A mutation showing the highest statistical significance in Autism and Schizophrenia.
The immunohistochemistry-based validation using tissue microarray slides in oral squamous cell carcinoma revealed overexpression of the RAB2A and PRDX1 (显示 PRDX1 抗体) gene in 80 and 68 % of the tested clinical cases, respectively.
Pin1 (显示 PIN1 抗体)/Rab2A/Erk (显示 EPHB2 抗体) drives BCSC expansion and tumorigenicity, suggesting potential drug targets.
As a result of the translocations, RAB2A-PLAG1 (显示 PLAG1 抗体), the constitutively active promoter of the partner gene drives the ectopic expression of PLAG1 (显示 PLAG1 抗体).
first X-ray crystal structure of RicA to 2.7 A resolution and have quantified the affinity of RicA binding to human Rab2 in its GDP-bound and nucleotide-free forms
The authors identified a specific interaction between the human small GTPase Rab2 and a Brucella spp. protein named RicA.
These results suggest that the dual effector, Noc2 (显示 RPH3AL 抗体), regulates the transition from Rab2a-mediated granule biogenesis to Rab27a (显示 RAB27A 抗体)-mediated granule exocytosis.
Symbiotic bacteria directed selective cargo sorting in Paneth cells to promote symbiosis through Nod2 (显示 NOD2 抗体) and LRRK2. Deficiency of Nod2 (显示 NOD2 抗体), LRRK2 or Rab2a or depletion of commensals resulted in lysosomal degradation of lysozyme (显示 LYZ 抗体).
Rab2A is a pivotal switch protein that promotes either secretion or endoplasmic reticulum-associated degradation of (pro)insulin (显示 INS 抗体) in insulin (显示 INS 抗体)-secreting cells.
An unprecedented direction of RAB2A-mediated vesicular transport in spermatids during acrosomal biogenesis, from the trans-side of the Golgi apparatus to the nuclear envelope.
CSFV proliferation was promoted by GBF1 (显示 GBF1 抗体) and Rab2 overexpression using a lentiviral system. Hence, Golgi function is important for CSFV multiplication, and GBF1 (显示 GBF1 抗体) and Rab2 participate in CSFV proliferation.
The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
RAB2, member RAS oncogene family
, ras-related protein Rab-2A
, small GTP binding protein RAB2A
, GTP-binding protein
, GTP-binding protein (rab2)
, RAB2A, member RAS oncogene family
, tubulovesicle-membrane-associated GTP-binding protein