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Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking.
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Human Monoclonal RAB26 Primary Antibody for ICC, WB - ABIN1742529
Binotti, Pavlos, Riedel, Wenzel, Vorbrüggen, Schalk, Kühnel, Boyken, Erck, Martens, Chua, Jahn: The GTPase Rab26 links synaptic vesicles to the autophagy pathway. in eLife 2015
Rab26 selectively directs synaptic and secretory vesicles into preautophagosomal structures.
Increased RAB26 expression causes lysosomes to coalesce in a central, perinuclear region within the cell.
The small GTPase (显示 RACGAP1 抗体) Rab26 regulates the Golgi to cell surface traffic of alpha(2)-adrenergic receptors, likely through a physical interaction.
MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D (显示 RAB3D 抗体).
Data show that pleckstrin (显示 PLEK 抗体) homology containing family member 5 (Plekhg5 (显示 PLEKHG5 抗体))-depleted cultured motoneurons show defective axon growth and impaired autophagy of synaptic vesicles, which can be rescued by constitutively active ras-related protein Rab-26 (Rab26).
Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000
Ras-related oncogene protein
, ras-related protein Rab-26
, RAB26, member RAS oncogene family