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The product of P2RY12 belongs to the family of G-protein coupled receptors. 再加上，我们可以发P2RY12 试剂盒 (24) 和 P2RY12 蛋白 (4)和数多这个蛋白质的别的产品。
Showing 10 out of 37 products:
Human Polyclonal P2RY12 Primary Antibody for IHC (p), WB - ABIN1394995
Garcia-Mesa, Jay, Checkley, Luttge, Dobrowolski, Valadkhan, Landreth, Karn, Alvarez-Carbonell: Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system. in Journal of neurovirology 2016
Human Polyclonal P2RY12 Primary Antibody for DB, ELISA - ABIN4342653
Abbracchio, Burnstock: Purinoceptors: are there families of P2X and P2Y purinoceptors? in Pharmacology & therapeutics 1995
Human Polyclonal P2RY12 Primary Antibody for IHC, IHC (p) - ABIN4342655
Bornø, Ploug, Bune, Rosenmeier, Thaning: Purinergic receptors expressed in human skeletal muscle fibres. in Purinergic signalling 2012
Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/P2Y13 (显示 P2RY13 抗体) receptors among BV-2 microglia.
findings not only revealed the critical role of P2Y12 in Th17 differentiation and EAE pathogenesis, but also suggested the promising potential of P2Y12 antagonists in the treatment of autoimmune diseases
P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice.
In P2Y12(-/-) mice, the growth of syngeneic ovarian cancer tumors was reduced by >85% compared with wild-type (WT) mice. In contrast, there was no difference in tumor growth between P2Y1 (显示 P2RY1 抗体)(-/-) and WT mice.
Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin (显示 CFL1 抗体) dephosphorylation, plays a critical role in the development of atherosclerotic lesions.
P2Y12 null mice are refractory to sepsis-induced lung injury, suggesting a key role for activated platelets and the P2Y12 receptor during sepsis.
excessive mechanical stress may induce a sustained release of ADP and promote SMC senescence via P2ry12-dependent sustained Ras activation, thereby contributing to excessive inflammation and degeneration, which provides insights into TAAD formation and progression.
AHR (显示 AHR 抗体) and airway inflammation in a mouse model of asthma. P2Y12 can be a novel therapeutic target to the suppression of eosinophils in asthma.
quinine/bupivacaine-sensitive potassium channels are the functional effectors of the P2Y12R-mediated signaling in microglia activation following neuronal injury
Disrupting P2Y12 alters the microglial response to monocular deprivation and abrogates ocular dominance plasticity.
miR (显示 MLXIP 抗体)-223, miR (显示 MLXIP 抗体)-26b, miR (显示 MLXIP 抗体)-126 and miR (显示 MLXIP 抗体)-140 are expressed at a lower level in platelets and megakaryocytes in type 2 diabetics causing up-regulation of P2RY12 and SELP (显示 SEPP1 抗体) mRNAs that may contribute to adverse platelet function.
The DHA - naringenin hybrid presented triple antiplatelet activity simultaneously targeting PAR-1 (显示 MARK2 抗体), P2Y12 and COX-1 (显示 COX1 抗体) platelet activation pathways
The results suggest that P2Y12 is a useful marker for the identification of human microglia throughout the lifespan. Moreover, P2Y12 expression might help to discriminate activated microglia and infiltrating myeloid cells from quiescent microglia in the human CNS.
P2RY12, the gene related to thrombogenesis was differentially expressed between the left atrium and right atrium in Sinus rhythm and Atrial fibrillation. Therefore, the changes in the expression of these genes were likely involved in the pathophysiology of AF-related thrombus formation.
Abnormalities of P2Y12 receptor include congenital deficiencies or high activity in diseases like diabetes mellitus and chronic kidney disease, exposing such patients to a prothrombotic condition. (Review)
Data suggest that PAR4 (显示 PAWR 抗体) and P2Y12 heterodimer internalization/endocytosis is required for beta-arrestin-2 (显示 ARRB2 抗体) recruitment to endosomes and up-regulation of Akt (显示 AKT1 抗体) signaling; activation of PAR4 (显示 PAWR 抗体) but not of P2Y12 drives internalization of the PAR4 (显示 PAWR 抗体)-P2Y12 heterodimer. (PAR4 (显示 PAWR 抗体) = protease-activated receptor 4 (显示 F2RL3 抗体); P2Y12 = purinergic receptor P2Y (显示 P2RY1 抗体), G-protein coupled, 12 protein; Akt (显示 AKT1 抗体) = proto-oncogene (显示 RAB1A 抗体) protein c (显示 PROC 抗体)-akt (显示 AKT1 抗体))
Studies indicate that purinergic receptor P2Y12 (P2Y12 receptor) gene C34T and G52T polymorphism might be a risk factor for the poor response to the platelet in patients on clopidogrel therapy.
studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation.
apart from the established association of the CYP2C19 *2 and *3 LOF alleles with high on-treatment platelet reactivity (HTPR), haplotypes of P2RY12 rs6798347, rs6787801, rs6801273, and rs6785930 rather than rs2046934 (T744C) that related to pharmacodynamics of clopidogrel in patients with ACS were independently associated with HTPR
The present report illustrates an update of dysfunctional platelet P2Y12R mutations diagnosed with congenital lifelong bleeding problems. [review]
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.
P2Y purinoceptor 12
, ADP-glucose receptor
, G-protein coupled receptor SP1999
, Gi-coupled ADP receptor HORK3
, P2Y12 platelet ADP receptor
, purinergic receptor P2RY12
, putative G-protein coupled receptor