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The product of P2RY12 belongs to the family of G-protein coupled receptors. 再加上，我们可以发P2RY12 试剂盒 (25) 和 P2RY12 蛋白 (5)和数多这个蛋白质的别的产品。
Showing 10 out of 38 products:
Human Polyclonal P2RY12 Primary Antibody for IHC (p), WB - ABIN1394995
Garcia-Mesa, Jay, Checkley, Luttge, Dobrowolski, Valadkhan, Landreth, Karn, Alvarez-Carbonell: Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system. in Journal of neurovirology 2016
Human Polyclonal P2RY12 Primary Antibody for DB, ELISA - ABIN4342653
Abbracchio, Burnstock: Purinoceptors: are there families of P2X and P2Y purinoceptors? in Pharmacology & therapeutics 1995
Human Polyclonal P2RY12 Primary Antibody for IHC, IHC (p) - ABIN4342655
Bornø, Ploug, Bune, Rosenmeier, Thaning: Purinergic receptors expressed in human skeletal muscle fibres. in Purinergic signalling 2012
Our finding demonstrated that genetic deletion of P2Y12 receptor broke the balance of Th subtypes by affecting the cytokine profile of bone marrow-derived dendritic cells and resulted in the aggravated experimental autoimmune encephalomyelitis, which suggested that P2Y12 may be a potential target in treating multiple sclerosis.
Study demonstrates a complementary role between TSSC6 (显示 TSPAN32 抗体) and P2Y12 receptor in platelets in regulating 'outside in' integrin alphaIIbbeta3 signalling thrombus growth and stability.
Findings offer insight into positive regulation of Akt (显示 AKT1 抗体) signaling through P2Y12 phosphorylation as well as MAPK (显示 MAPK1 抗体) signaling in platelets by ASK1 (显示 MAP3K5 抗体).
CLEC-2 (显示 CLEC1B 抗体) and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis, and might be targeted to prevent adverse events in patients at risk.
Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/P2Y13 (显示 P2RY13 抗体) receptors among BV-2 microglia.
findings not only revealed the critical role of P2Y12 in Th17 differentiation and EAE pathogenesis, but also suggested the promising potential of P2Y12 antagonists in the treatment of autoimmune diseases
P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice.
In P2Y12(-/-) mice, the growth of syngeneic ovarian cancer tumors was reduced by >85% compared with wild-type (WT) mice. In contrast, there was no difference in tumor growth between P2Y1 (显示 P2RY1 抗体)(-/-) and WT mice.
Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin (显示 CFL1 抗体) dephosphorylation, plays a critical role in the development of atherosclerotic lesions.
P2Y12 null mice are refractory to sepsis-induced lung injury, suggesting a key role for activated platelets and the P2Y12 receptor during sepsis.
We documented a different effect of CYP2C19 (显示 CYP2C19 抗体) and P2Y12 receptor polymorphisms on platelet reactivity and cardiovascular outcome in coronary artery disease patients after percutaneous coronary intervention on clopidogrel treatment. Importantly, increased platelet reactivity adversely affects the cardiovascular outcome independently of the studied polymorphisms.
Genomic association study identified deleterious rare variants in P2RY12 in patients with ischemic stroke.
Expression of platelet hsa-miR-223 increased and P2RY12 mRNA reduced in type 2 diabetic patients following ET non-significantly.
The meta-analysis shows a potential of association between P2RY12 gene polymorphisms and higher risks of composite ischemic events for coronary artery disease patients treated with clopidogrel. [review]
miR (显示 MLXIP 抗体)-223, miR (显示 MLXIP 抗体)-26b, miR (显示 MLXIP 抗体)-126 and miR (显示 MLXIP 抗体)-140 are expressed at a lower level in platelets and megakaryocytes in type 2 diabetics causing up-regulation of P2RY12 and SELP (显示 SEPP1 抗体) mRNAs that may contribute to adverse platelet function.
The DHA - naringenin hybrid presented triple antiplatelet activity simultaneously targeting PAR-1 (显示 MARK2 抗体), P2Y12 and COX-1 (显示 COX1 抗体) platelet activation pathways
The results suggest that P2Y12 is a useful marker for the identification of human microglia throughout the lifespan. Moreover, P2Y12 expression might help to discriminate activated microglia and infiltrating myeloid cells from quiescent microglia in the human CNS.
P2RY12, the gene related to thrombogenesis was differentially expressed between the left atrium and right atrium in Sinus rhythm and Atrial fibrillation. Therefore, the changes in the expression of these genes were likely involved in the pathophysiology of AF-related thrombus formation.
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.
P2Y purinoceptor 12
, ADP-glucose receptor
, G-protein coupled receptor SP1999
, Gi-coupled ADP receptor HORK3
, P2Y12 platelet ADP receptor
, purinergic receptor P2RY12
, putative G-protein coupled receptor