PPP4C 抗体
(Protein Phosphatase 4, Catalytic Subunit (PPP4C))
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
recommended
recommended
recommended
PPP4C 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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Bat, Cow, Dog, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Xenopus laevis, Zebrafish (Danio rerio)
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Datasheet
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Latest Publications for our PPP4C 抗体
: "Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers." in: eLife, Vol. 3, pp. e01695, (2014) (PubMed).: "Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells." in: Biochimica et biophysica acta, Vol. 1783, Issue 8, pp. 1490-502, (2008) (PubMed).
: "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation." in: The Journal of biological chemistry, Vol. 279, Issue 25, pp. 26143-8, (2004) (PubMed).
: "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation." in: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 46588-94, (2004) (PubMed).
: "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49551-61, (2004) (PubMed).
Aliases for PPP4C 抗体
protein phosphatase 4 catalytic subunit (ppp4c) 抗体protein phosphatase 4, catalytic subunit a (ppp4ca) 抗体
protein phosphatase 4 catalytic subunit (PPP4C) 抗体
protein phosphatase 4, catalytic subunit (Ppp4c) 抗体
protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S) 抗体
1110002D08Rik 抗体
AU016079 抗体
gc:56413 抗体
MGC75928 抗体
pp4 抗体
PP4 抗体
pp4c 抗体
PP4C 抗体
PP4C-A 抗体
pph3 抗体
PPH3 抗体
PPP4 抗体
ppp4c 抗体
ppx 抗体
PPX 抗体
Ppx 抗体
wu:fd05e08 抗体
zgc:56413 抗体
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