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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 抗体

(Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
PPM1A 抗体  (AA 2-382) PPM1A 抗体  (AA 2-382) PPM1A 抗体 (AA 2-382) (ABIN7441469)

PPM1A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

PPM1A 抗体  (AA 202-382) PPM1A 抗体  (AA 202-382) PPM1A 抗体 (AA 202-382) (ABIN969556)

PPM1A 适用: 人, 猴 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 7F12 unconjugated

PPM1A 抗体  (AA 1-382) PPM1A 抗体  (AA 1-382) PPM1A 抗体 (AA 1-382) (ABIN519084)

PPM1A 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 4E11 unconjugated

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Find Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 抗体 for a variety of species such as anti-Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A, anti-Mouse Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A, anti-Rat Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A. The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7441469
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey
Application WB, ELISA, FACS
Validations
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  • (5)
Cat. No. ABIN969556
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p), PLA
Validations
  • (5)
Cat. No. ABIN519084
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN6146039
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, ICC
Validations
  • (2)
  • (3)
Cat. No. ABIN532910
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF
Validations
  • (2)
Cat. No. ABIN7011306
Quantity 60 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7165941
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN948299
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN790507
Quantity 50 μg
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN6744214
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN5679767
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF, IC
Validations
  • (2)
Cat. No. ABIN7306766
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
Cat. No. ABIN711761
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
Cat. No. ABIN7094539
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
Cat. No. ABIN7118037
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 抗体

Kwon, Choi, Lee, Park, Lee, Kim, Kim, Shin, Kim, Hong, Lee, Yoo, William, Kim, Chang: "The intracellular protein phosphatase magnesium-dependent 1A negatively regulates osteoclast commitment." in: Arthritis & rheumatology (Hoboken, N.J.), (2019) (PubMed).

Juhasz, Markel, Gaur, Liu, Lu, Jiang, Wu, Antony, Wu, Melillo, Meitzler, Haines, Butcher, Roy, Doroshow: "NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction." in: The Journal of biological chemistry, Vol. 292, Issue 19, pp. 7866-7887, (2017) (PubMed).

Malki, Uher, Paya-Cano, Binder, Rietschel, Zobel, Mors, Hauser, Henigsberg, Jerman, Souery, Placentino, Ng, Cohen-Woods, Sluyter, Farmer, Aitchison, Craig, Lewis, McGuffin, Schalkwyk: "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." in: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).

Sun, Yu, Dotti, Shen, Tan, Savoldo, Pass, Chu, Zhang, Lu, Fu, Lin, Yang: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." in: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).

Lin, Duan, Liang, Su, Wrighton, Long, Hu, Davis, Wang, Brunicardi, Shi, Chen, Meng, Feng: "PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling." in: Cell, Vol. 125, Issue 5, pp. 915-28, (2006) (PubMed).

Duan, Liang, Feng, Lin: "Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway." in: The Journal of biological chemistry, Vol. 281, Issue 48, pp. 36526-32, (2006) (PubMed).

Yoshizaki, Maegawa, Egawa, Ugi, Nishio, Imamura, Kobayashi, Tamura, Olefsky, Kashiwagi: "Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22715-26, (2004) (PubMed).

Ofek, Ben-Meir, Kariv-Inbal, Oren, Lavi: "Cell cycle regulation and p53 activation by protein phosphatase 2C alpha." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 14299-305, (2003) (PubMed).

Flajolet, Rakhilin, Wang, Starkova, Nuangchamnong, Nairn, Greengard: "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 26, pp. 16006-11, (2003) (PubMed).

Aliases for Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 抗体

protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A) 抗体
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab (ppm1ab) 抗体
protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a) 抗体
protein phosphatase, Mg2+/Mn2+ dependent, 1A (Ppm1a) 抗体
protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog (ppm1a.L) 抗体
protein phosphatase, Mg2+/Mn2+ dependent 1A (Ppm1a) 抗体
protein phosphatase, Mg2+/Mn2+ dependent, 1Aa (ppm1aa) 抗体
2310003C21Rik 抗体
2900017D14Rik 抗体
AI427932 抗体
AU017636 抗体
MMPa-2 抗体
MPPa-1 抗体
PP2C-ALPHA 抗体
pp2c-alpha 抗体
Pp2c1 抗体
PP2CA 抗体
pp2ca 抗体
pp2ca1 抗体
pp2ca2 抗体
PP2Calpha 抗体
pp2calpha 抗体
ppp1r13b 抗体
si:ch211-253p18.1 抗体
wu:fd42g12 抗体
zgc:153820 抗体

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