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PRSS12 encodes a member of the trypsin family of serine proteases. 再加上，我们可以发Protease, serine, 12 (Neurotrypsin, Motopsin) 抗体 (29) 和 Protease, serine, 12 (Neurotrypsin, Motopsin) 试剂盒 (2)和数多这个蛋白质的别的产品。
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4-base pair deletion in the neurotrypsin gene was associated with autosomal recessive nonsyndromic mental retardation; findings suggest that neurotrypsin-mediated proteolysis is required for normal synaptic function
This study identifies Tequila and neurotrypsin as new genes repressed by presenilins and reveals a novel mechanism used by presenilins to modulate CREB (显示 CREB1 蛋白) signaling based on controlling CREB (显示 CREB1 蛋白) recruitment.
co-expression of sez-6 with motopsin restored the effect of motopsin at the basal level, while sez-6 expression alone showed no effects on cell morphology. Our results suggest that the interaction of motopsin and sez-6 modulates neuronal cell morphology
Our results indicate that an extracellular protease, motopsin, preferentially affects social behaviors, and modulates the functions of hippocampal neurons.
motopsin has multiple functions, such as axon outgrowth, arranging perineuronal environment, and maintaining neuronal plasticity, partly in coordination with other proteases including tissue plasminogen activator (显示 PLAT 蛋白).
neurotrypsin exclusively cleaves glycanated variants of agrin (显示 AGRN 蛋白); neurotrypsin-dependent cleavage of agrin (显示 AGRN 蛋白) was concentrated at synapses, where the most heavily glycanated variants of agrin (显示 AGRN 蛋白) predominate
Detailed analyses indicated that presynaptic action potential firing is necessary for the release of neurotrypsin, whereas postsynaptic NMDA receptor activation is necessary for the neurotrypsin-dependent cleavage of agrin (显示 AGRN 蛋白).
This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1).
protease, serine, 12 (neurotrypsin, motopsin)
, 26S proteasome regulatory SU
, brain-specific serine protease 3
, serine protease 12
, peptidase, serine, 12 (neurotrypsin, motopsin)