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The protein encoded by PCSK7 belongs to the subtilisin-like proprotein convertase family. 再加上，我们可以发Proprotein Convertase Subtilisin/kexin Type 7 抗体 (29) 和 Proprotein Convertase Subtilisin/kexin Type 7 蛋白 (8)和数多这个蛋白质的别的产品。
SPC7 is required for normal development of the eye and brain, possibly through processing BMPs, though other potential substrates cannot be excluded.
PCSK7 is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
Our present data suggest that PCSK7 as well as PCSK9 (显示 PCSK9 ELISA试剂盒) may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes.
PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis (显示 HFE ELISA试剂盒).
Furin (显示 FURIN ELISA试剂盒) and PC7 siRNAs induced HIF-1alpha (显示 HIF1A ELISA试剂盒) protein by increasing its translation, resulting in upregulation of VEGF-A (显示 VEGFA ELISA试剂盒).
The data suggest that PCSK7 genotypes may interact with dietary CHO (显示 COL11A1 ELISA试剂盒) intake on changes in insulin (显示 INS ELISA试剂盒) sensitivity in the white Americans.
Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis (显示 HFE ELISA试剂盒) patients homozygous for HFE (显示 HFE ELISA试剂盒) C282Y.
overexpression of PCs, furin (显示 FURIN ELISA试剂盒) and PC5 (显示 PCSK5 ELISA试剂盒), but not PC7, which are all expressed in SMC (显示 DYM ELISA试剂盒), increase PKGI (显示 PRKG1 ELISA试剂盒) cleavage in a dose-dependent manner
Among the PC family members, only furin (显示 FURIN ELISA试剂盒) activates hepcidin (显示 HAMP ELISA试剂盒) in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100
PCSK7 is involved in sTfR (显示 TFRC ELISA试剂盒) generation and iron homeostasis.
Proprotein convertase PC7 enhances the activation of the EGF receptor (显示 EGFR ELISA试剂盒) pathway through processing of the EGF (显示 EGF ELISA试剂盒) precursor.
PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.
PC7 has a critical role in normal processing of cholecystokinin (显示 CCK ELISA试剂盒) in mouse brain
PC7 and the related proteases Furin (显示 FURIN ELISA试剂盒) and Pace4 (显示 PCSK6 ELISA试剂盒) regulate E-cadherin (显示 CDH1 ELISA试剂盒) function during blastocyst formation.
Data show that BDNF (显示 BDNF ELISA试剂盒) and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF (显示 BDNF ELISA试剂盒) protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice.
in binding VEGFR-2 (显示 KDR ELISA试剂盒), furin (显示 FURIN ELISA试剂盒) and PC5 (显示 PCSK5 ELISA试剂盒) promote cleavage of N-and C-terminal VEGF-D (显示 Figf ELISA试剂盒) propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.
proprotein convertase PC7
, proprotein convertase subtilisin/kexin type 7
, proprotein convertase subtilisin/kexin type 7-like
, lymphoma proprotein convertase
, prohormone convertase 7
, prohormone convertase PC7
, proprotein convertase 7
, proprotein convertase 8
, subtilisin/kexin-like protease PC7
, subtilisin-like proprotein convertase 7