anti-Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) 抗体

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. 再加上,我们可以发PDCD4 试剂盒 (16)PDCD4 蛋白 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PDCD4 27250 Q53EL6
PDCD4 18569 Q61823
PDCD4 64031 Q9JID1
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antibodies-online.cn销售最多的anti-PDCD4 抗体

Showing 10 out of 243 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB <b>WB Suggested Anti-PDCD4 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
小鼠 非结合性 EIA, IHC (p), WB 0.1 mL Log in to see 6至8个工作日
$412.50
详细
小鸡 非结合性 IHC, WB Immunohistochemical analysis of PDCD4 (pS457) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of PDCD4 (pS457) expression in HeLa (A), Jurkat (B) whole cell lysates. 200 μL Log in to see 13至14个工作日
$575.00
详细
非结合性 IP, IHC, ELISA, WB Affinity purified anti-Pdcd4 was used at a 1:100 dilution to detect Pdcd4 by immunohistochemistry on mouse colon tissue. Tissue was fixed in 4% paraformaldehyde and paraffin embedded. Tissue sections were deparaffinized and treated by trypsinization before staining. 100 μg Log in to see 1至2个工作日
$389.00
详细
非结合性 IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with serum 20% 15', using PDCD4 (Phospho-Ser457) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using PDCD4 (Phospho-Ser457) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 IF, ELISA, WB Western blot analysis of extracts from 293 cells, using PDCD4 (Ab-457) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using PDCD4 (Ab-457) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 ELISA, WB Western blot analysis of extracts from HuvEc cells, K562 cells and COS-7 cells, using PDCD4 (Phospho-Ser67) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
山羊 非结合性 ELISA, WB Western Blot: PDCD4 Antibody [NBP2-26139] - (0.1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7至9个工作日
$485.88
详细
山羊 非结合性 ELISA, WB Western Blot: PDCD4 Antibody [NBP2-26138] - (1ug/ml) staining of nuclear HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7至9个工作日
$485.88
详细
小鼠 Biotin IHC, ELISA, WB Western Blot of Mouse anti-Pdcd4 phospho S457 Biotin Conjugated antibody. Lane 1: Pdcd4 recombinant protein. Lane 2: none. Load: 100 ng per lane. Primary antibody: Pdcd4 phospho S457 Biotin Conjugated antibody at 1:1,000 for overnight at 4°C. Secondary antibody: HRP Streptavidin secondary antibody at 1:40,000 for 30 min at RT. Block: MB-070 for 30 min at RT. Predicted/Observed size: 50 kDa, 50 kDa for Pdcd4 phospho S457. Other band(s): Pdcd4 phospho S457 splice variants and isoforms 50 μg Log in to see 1至2个工作日
$300.00
详细

通过反应活性、应用领域、克隆类型和共轭标记 PDCD4 抗体

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引用最多的anti-PDCD4 抗体

  1. Human Polyclonal PDCD4 Primary Antibody for IHC, IHC (p) - ABIN4344378 : Baffa, Fassan, Volinia, OHara, Liu, Palazzo, Gardiman, Rugge, Gomella, Croce, Rosenberg: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. in The Journal of pathology 2009 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1002982 : Yang, Jansen, Komar, Zheng, Merrick, Costes, Lockett, Sonenberg, Colburn: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. in Molecular and cellular biology 2002 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal PDCD4 Primary Antibody for ELISA, IHC - ABIN4344376 : Jia, Teng, Zou, Fang, Wu, Liang, Ding: Xenon Protects Against Septic Acute Kidney Injury via miR-21 Target Signaling Pathway. in Critical care medicine 2015 (PubMed)
    Show all 2 Pubmed References

  4. Cow (Bovine) Polyclonal PDCD4 Primary Antibody for WB - ABIN2792230 : Yang, Cho, Zakowicz, Hegamyer, Sonenberg, Colburn: A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. in Molecular and cellular biology 2004 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal PDCD4 Primary Antibody for IF (p), IHC (p) - ABIN731993 : Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043728 : Jansen, Camalier, Colburn: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. in Cancer research 2005 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043755 : Huang, Wu, Loeb, Hsu, Heidersbach, Brincat, Horiuchi, Lebbink, Mo, Goga, McManus: Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal PDCD4 Primary Antibody for IP, IHC - ABIN129709 : Santhanam, Baker, Hegamyer, Kirschmann, Colburn: Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion. in Oncogene 2010 (PubMed)
    Show all 2 Pubmed References

  9. Human Polyclonal PDCD4 Primary Antibody for IP - ABIN188776 : Kruiswijk, Yuniati, Magliozzi, Low, Lim, Bolder, Mohammed, Proud, Heck, Pagano, Guardavaccaro: Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. in Science signaling 2012 (PubMed)

  10. Human Polyclonal PDCD4 Primary Antibody for IHC (p), ELISA - ABIN2476088 : Palamarchuk, Efanov, Maximov, Aqeilan, Croce, Pekarsky: Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. in Cancer research 2005 (PubMed)

更多抗PDCD4的相互作用对抗体

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. PDCD4 is expressed in the cytoplasm of glandular epithelium of control endometrium and varied during the cycle changes of endometrium. Compared with the proliferative phase of control endometrium, PDCD4 expression was down-regulated in proliferative phase of eutopic or ectopic endometrium. There was no cyclic variation of PDCD4 expression in eutopic endometrium of adenomyosis patients due to progesterone resistance.

  2. Study confirmed that PDCD4 was downregulated in non-small cell lung cancer (NSCLC). PDCD4 is a functional target for miR (显示 MLXIP 抗体)-155 at both transcriptional and post-transcriptional levels.

  3. We demonstrated that miR (显示 MLXIP 抗体)-208a-3p suppressed apoptosis in gastric cancer cells by targeting PDCD4.

  4. PDCD4 is involved in negative control of stromal fibroblasts conversion into cancer associated fibroblast

  5. Results identify PDCD4 as a novel RSK (显示 RPS6KA1 抗体) substrate. Authors demonstrate that RSK (显示 RPS6KA1 抗体)-mediated phosphorylation of PDCD4 at S76 promotes PDCD4 degradation.

  6. evaluate the relative expression levels of miR (显示 MLXIP 抗体)-196a2 and three of its selected apoptosis-related targets; ANXA1 (显示 ANXA1 抗体), DFFA (显示 DFFA 抗体) and PDCD4 in a sample of GI cancer patients

  7. In colorectal cancer tissues, the Sin1 (显示 MAPKAP1 抗体) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (显示 MAPKAP1 抗体) protein level but not mRNA level in colorectal cancer.

  8. miRNA-96 is significantly overexpressed in glioma tissues. Moreover, miRNA-96 plays a critical role in apoptosis by inhibiting the expression of PDCD4 in glioma.

  9. Supporting the clinical relevance of our results, we found an inverse correlation between ErbB-2 (显示 ERBB2 抗体)/Stat3 (显示 STAT3 抗体) nuclear co-expression and PDCD4 expression in ErbB-2 (显示 ERBB2 抗体)-positive primary invasive breast cancer

  10. this study highlights an oncomiR role for miR (显示 MLXIP 抗体)-181b in regulating PDCD4 in colorectal cancer and suggests that miR (显示 MLXIP 抗体)-181b may be a novel molecular therapeutic target for colorectal cancer.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. In colorectal cancer tissues, the Sin1 (显示 MAPKAP1 抗体) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (显示 MAPKAP1 抗体) protein level but not mRNA level in colorectal cancer.

  2. -induced expression of PDCD4 is associated with increased beta cell death.

  3. miR (显示 MLXIP 抗体)-155 not only directly inhibited SOCS1 (显示 SOCS1 抗体) expression, but also increased the expression of p-STAT (显示 STAT1 抗体) and PDCD4, as well as the production of proinflammation mediators IL-6 (显示 IL6 抗体) and TNF-alpha (显示 TNF 抗体) in atherogenesis

  4. our data suggest that Pdcd4 as a crucial regulator in SGs (显示 SKI 抗体) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

  5. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (显示 IL10 抗体).

  6. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (显示 IL6 抗体)/STAT3 (显示 STAT3 抗体) Pathway.

  7. Study found that miR-16 (显示 GDE1 抗体) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (显示 NFKB1 抗体) and MAPK (显示 MAPK1 抗体) pathways.

  8. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

  9. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

  10. In conclusion, miR (显示 MLXIP 抗体)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. miR (显示 MYLIP 抗体)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (显示 NFKB1 抗体)/ TNF-alpha (显示 TNF 抗体) pathway in cardiomyocytes.

PDCD4 抗原简介

蛋白简介

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PDCD4

  • programmed cell death 4 (PDCD4) 抗体
  • programmed cell death 4 (Pdcd4) 抗体
  • programmed cell death 4b (pdcd4b) 抗体
  • programmed cell death 4 L homeolog (pdcd4.L) 抗体
  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4) 抗体
  • programmed cell death 4 (pdcd4) 抗体
  • cb45 抗体
  • D19Ucla1 抗体
  • Dug 抗体
  • h731 抗体
  • Ma3 抗体
  • MGC69337 抗体
  • PDCD4 抗体
  • sb:cb45 抗体
  • Tis 抗体
  • wu:fc84b08 抗体

Protein level used designations for PDCD4

neoplastic transformation inhibitor protein , nuclear antigen H731 , programmed cell death protein 4 , protein 197/15a , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , protein I11/6 , programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4-like

GENE ID SPECIES
27250 Homo sapiens
18569 Mus musculus
64031 Rattus norvegicus
321061 Danio rerio
380222 Xenopus laevis
506724 Bos taurus
374191 Gallus gallus
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
477818 Canis lupus familiaris
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
100157112 Sus scrofa
100173014 Pongo abelii
100723476 Cavia porcellus
anti-PDCD4 (PDCD4) 抗体 精选生产商
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