anti-Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) 抗体

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. 再加上,我们可以发PDCD4 试剂盒 (19)PDCD4 蛋白 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PDCD4 27250 Q53EL6
PDCD4 18569 Q61823
PDCD4 64031 Q9JID1
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antibodies-online.cn销售最多的anti-PDCD4 抗体

Showing 10 out of 257 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: PDCD4 Antibody [NBP1-83302] - Staining of human breast shows strong cytoplasmic positivity in glandular cells. Western Blot: PDCD4 Antibody [NBP1-83302] - Lane 1: Marker [kDa] 207, 110, 79, 49, 32, 25, 17.Lane 2: Human cell line RT-4 0.1 mL Log in to see 10至13个工作日
$494.38
详细
Cow 非结合性 WB WB Suggested Anti-PDCD4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Jurkat cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
山羊 非结合性 ELISA, IHC, WB Antibody (0.1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$429.84
详细
非结合性 IHC (p), WB PDCD4 Antibody (Center) (ABIN657922) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the PDCD4 antibody detected the PDCD4 protein (arrow). ABIN2846869 staining PDCD4 in human breast tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. Dilution: 1:25 400 μL Log in to see 10至11个工作日
$385.00
详细
小鼠 非结合性 EIA, IHC (p), WB 0.1 mL Log in to see 6至8个工作日
$390.50
详细
小鼠 非结合性 IHC, ELISA, WB Antibody 200-301-964 has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The antibody was serially diluted and tested at a range of concentrations on at least 22 different human formalin-fixed, paraffin archival tissues, and positive and negative tissues were scored and compared to the published literature on the expression and function of the gene. A representative image from positively stained small intestine shows the localization of the anti Pdcd4 antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain. Image provided courtesy of LifeSpan Biosciences, Seattle, WA Western blot using  Immunochemicals Protein A purified Mouse Monoclonal anti-Pdcd4 pS457 antibody against recombinant PDCD4 protein. Membrane was blocked in 1% BSA-TBS-T for 30 min RT and probed with 1° Ab Ms-A-Pdcd4pS457 1:1000 (o/n 4°C in 1% BSA-TBS-T) followed by 2° Ab Peroxidase Conjugated Rabbit anti Ms CUST10M Lot# 20121 at 1:40,000 in ABIN925618 30 min RT. Bands at ~62 kD and ~32 kD were detected. 100 μg Log in to see 5至7个工作日
$598.50
详细
小鸡 非结合性 IHC, WB Immunohistochemical analysis of PDCD4 (pS457) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of PDCD4 (pS457) expression in HeLa (A), Jurkat (B) whole cell lysates. 200 μL Log in to see 13至14个工作日
$575.00
详细
小鼠 非结合性 ELISA, IHC, IHC (p), WB Human Breast (formalin-fixed, paraffin-embedded) stained with PDCD4 antibody ABIN364343 at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Spleen (formalin-fixed, paraffin-embedded) stained with PDCD4 antibody ABIN364343 at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 11至14个工作日
$563.44
详细
非结合性 IF, ELISA, WB Western blot analysis of extracts from 293 cells, using PDCD4 (Ab-457) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using PDCD4 (Ab-457) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 ELISA, WB Western blot analysis of extracts from HuvEc cells, K562 cells and COS-7 cells, using PDCD4 (Phospho-Ser67) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细

引用最多的anti-PDCD4 抗体

  1. Human Polyclonal PDCD4 Primary Antibody for IHC, IHC (p) - ABIN4344378 : Baffa, Fassan, Volinia, OHara, Liu, Palazzo, Gardiman, Rugge, Gomella, Croce, Rosenberg: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. in The Journal of pathology 2009 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1002982 : Yang, Jansen, Komar, Zheng, Merrick, Costes, Lockett, Sonenberg, Colburn: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. in Molecular and cellular biology 2002 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043728 : Jansen, Camalier, Colburn: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. in Cancer research 2005 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043755 : Huang, Wu, Loeb, Hsu, Heidersbach, Brincat, Horiuchi, Lebbink, Mo, Goga, McManus: Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal PDCD4 Primary Antibody for IP, IHC - ABIN129709 : Santhanam, Baker, Hegamyer, Kirschmann, Colburn: Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion. in Oncogene 2010 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal PDCD4 Primary Antibody for IF (p), IHC (p) - ABIN731993 : Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal PDCD4 Primary Antibody for IHC (p), WB - ABIN541289 : Shibahara, Asano, Ishida, Aoki, Koike, Honjo: Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. in Gene 1996 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal PDCD4 Primary Antibody for ELISA, WB - ABIN532983 : Palamarchuk, Efanov, Maximov, Aqeilan, Croce, Pekarsky: Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. in Cancer research 2005 (PubMed)
    Show all 2 Pubmed References

  9. Cow (Bovine) Polyclonal PDCD4 Primary Antibody for WB - ABIN2792230 : Yang, Cho, Zakowicz, Hegamyer, Sonenberg, Colburn: A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. in Molecular and cellular biology 2004 (PubMed)
    Show all 3 Pubmed References

  10. Human Polyclonal PDCD4 Primary Antibody for ELISA, IHC - ABIN4344376 : Jia, Teng, Zou, Fang, Wu, Liang, Ding: Xenon Protects Against Septic Acute Kidney Injury via miR-21 Target Signaling Pathway. in Critical care medicine 2015 (PubMed)
    Show all 2 Pubmed References

更多抗PDCD4的相互作用对抗体

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. Study established that upregulation of miR-96 in glioblastoma multiforme (GBM) cells confers radioresistance via targeting PDCD4, which might be a potential therapeutic target for GBM.

  2. This study revealed a dynamic regulatory relationship between PDCD4 and critical factors for EMT, establishing a broad, functional role for PDCD4 in laryngeal carcinoma, which may be propagated by the STAT3-miR-21 pathway.

  3. the localization of Pdcd4 to the cytoplasm may be responsible for the suppression of the target mRNA translation and apoptosis.

  4. PDCD4 and PTEN were the functional targets of miR-21.

  5. Various studies support evidence that PDCD4, is a novel tumor suppressor gene, and is downregulated or even absent in colorectal cancer (CRC) and suppresses CRC deterioration. [review]

  6. In the high malignant group the PDCD4 mRNA and PDCD5 mRNA expressions were significantly decreased compared with the low malignant group and the control group. PDCD4 mRNA and PDCD5 mRNA expressions are promising targets for the diagnosis and treatment of glioma.

  7. miR-21 may promote salivary adenoid cystic carcinoma progression via PDCD4 and PTEN down-regulation and Bcl-2 up-regulation.

  8. The expression of PDCD4 is decreased in cervical cancer tissues, compared to miR-150 which is increased.

  9. Our study demonstrated that lncRNA-XIST, which acts as a miRNA sponge, impedes miR-21-5p to maintain the expression of PDCD4, which contributes to the progression of osteosarcoma (OS). Our findings suggest that the newly identified XIST/miR-21-5p/PDCD4 axis could be a potential biomarker or therapeutic target for OS.

  10. miR206 promoted the onset of SANFH by inducing apoptosis and suppressed the proliferation of osteoblasts, which was dependent on the inhibition of PDCD4.

  11. Results found PDCD4 as a target gene of miR-93 and miR-93 could down-regulate the expression of PDCD4 by directly targeting its 3'-UTR. The re-expression of PDCD4 could attenuate the hepatocellular carcinoma (HCC) cell invasion and migration induced by miR-93, while the knockdown of PDCD4 would promote HCC cell migration and invasion via the EMT pathway.

  12. Reduced expression of PDCD4 was found in decidual and chorionic tissues, and peripheral blood mononuclear cells from patients with missed abortion.

  13. miR503 promotes tumour growth and invasion by directly targeting PDCD4.

  14. A novel mechanism of Pdcd4 action as a translation inhibitor and tumor suppressor has been proposed.

  15. Taken together, this study highlights an important role for miR-23a/b as oncomiRs in gastric cancer through the inhibition of PDCD4 translation. These findings may shed new light on the molecular mechanism of gastric carcinogenesis and provide a new avenue for gastric cancer treatment.

  16. lncRNA CASC9 functions as an oncogene by negatively regulating PDCD4 expression through recruiting EZH2 and subsequently altering H3K27me3 level. Our study implicates lncRNA CASC9 as a valuable biomarker for ESCC diagnosis and prognosis.

  17. Exosomes derived from cisplatin-resistant OSCC cells transferred miR-21 to oral squamous cell carcinoma (OSCC) parental cells and induced cisplatin resistance by targeting phosphatase and tensin homolog (PTEN) and programmed cell death 4 (PDCD4).

  18. These results indicate that the ROS-STAT3-miR-21-PDCD4 signaling axis plays an important role in arsenic -induced carcinogenesis.

  19. PDCD4 is expressed in the cytoplasm of glandular epithelium of control endometrium and varied during the cycle changes of endometrium. Compared with the proliferative phase of control endometrium, PDCD4 expression was down-regulated in proliferative phase of eutopic or ectopic endometrium. There was no cyclic variation of PDCD4 expression in eutopic endometrium of adenomyosis patients due to progesterone resistance.

  20. Study confirmed that PDCD4 was downregulated in non-small cell lung cancer (NSCLC). PDCD4 is a functional target for miR-155 at both transcriptional and post-transcriptional levels.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. These skeletal effects were attributed to inhibition of bone resorption and osteoclast function by miR-21 deficiency through miR-21 targeting programmed cell death 4 (PDCD4), despite the existence of RANKL. As far as we know, this is the first in vivo evidence of a pro-osteoclastic microRNA.

  2. MEG3 functions as a competing endogenous RNAs (ceRNAs) and competes with PDCD4 mRNA for directly binding to miR-21, which mediates ischemic neuronal death.

  3. In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 protein level but not mRNA level in colorectal cancer.

  4. -induced expression of PDCD4 is associated with increased beta cell death.

  5. miR-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT and PDCD4, as well as the production of proinflammation mediators IL-6 and TNF-alpha in atherogenesis

  6. our data suggest that Pdcd4 as a crucial regulator in SGs induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

  7. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10.

  8. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway.

  9. Study found that miR-16 was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB and MAPK pathways.

  10. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

  11. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

  12. In conclusion, miR-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.

  13. atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells

  14. we demonstrate that miR-21 regulates T-cell acute lymphoblastic leukemia cell survival via repression of the tumor suppressor Pdcd4.

  15. Dual expression of shAkt1 and Pdcd4 effectively suppresses lung tumorigenesis

  16. miR-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3/8 fragments in the condition of renal IRI

  17. sulforaphane protects PDCD4 downregulation posed by pro-inflammatory stimuli through modulating both transcription and proteolysis via controlling Akt1 and/or S6K1 activities in RAW 264.7 cells

  18. these findings support the existence of a microRNA-21-responsive PDCD4/caspase-3 pathway in the pulmonary tissues that when active serves to promote endothelial apoptosis in vitro and pulmonary hypertension in vivo.

  19. we demonstrated that the miR-21-PDCD4 signaling was involved in the cellular responses to UVB in a mouse epidermal cell line

  20. during bacterial pneumonia IFNlambda promotes inflammation by inhibiting miR-21 regulation of PDCD4.

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. miR-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes.

PDCD4 抗原简介

蛋白简介

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PDCD4

  • programmed cell death 4 (PDCD4) 抗体
  • programmed cell death 4 (Pdcd4) 抗体
  • programmed cell death 4b (pdcd4b) 抗体
  • programmed cell death 4 L homeolog (pdcd4.L) 抗体
  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4) 抗体
  • programmed cell death 4 (pdcd4) 抗体
  • cb45 抗体
  • D19Ucla1 抗体
  • Dug 抗体
  • h731 抗体
  • Ma3 抗体
  • MGC69337 抗体
  • PDCD4 抗体
  • sb:cb45 抗体
  • Tis 抗体
  • wu:fc84b08 抗体

Protein level used designations for PDCD4

neoplastic transformation inhibitor protein , nuclear antigen H731 , programmed cell death protein 4 , protein 197/15a , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , protein I11/6 , programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4-like

GENE ID SPECIES
27250 Homo sapiens
18569 Mus musculus
64031 Rattus norvegicus
321061 Danio rerio
380222 Xenopus laevis
506724 Bos taurus
374191 Gallus gallus
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
477818 Canis lupus familiaris
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
100157112 Sus scrofa
100173014 Pongo abelii
100723476 Cavia porcellus
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