anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) 抗体

KCNH2 encodes a voltage-activated potassium channel belonging to the eag family. 再加上,我们可以发Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
KCNH2 3757 Q12809
KCNH2 16511  
KCNH2 117018 O08962
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antibodies-online.cn销售最多的anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 抗体

Showing 10 out of 93 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-KCNH2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  OVCAR-3 cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 WB WB Suggested Anti-Kcnh2 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Kidney 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 WB Anti- KCNH2 Picoband antibody, Western blotting All lanes: Anti KCNH2  at 0.5ug/ml Lane 1: Rat Brain Tissue Lysate at 50ug Lane 2: HELA Whole Cell Lysate at 40ug Lane 3: COLO320 Whole Cell Lysate at 40ug Lane 4: MM231 Whole Cell Lysate at 40ug Predicted bind size: 127KD Observed bind size: 127KD Anti- KCNH2 Picoband antibody, Western blotting All lanes: Anti KCNH2  at 0.5ug/ml WB: Recombinant Human KCNH2 Protein 0.5ng Predicted bind size: 42KD Observed bind size: 42KD 100 μg Log in to see 4至6个工作日
$240.00
详细
Bat 非结合性 IHC, IHC (p) Anti-KCNH2 / Kv11.1 antibody  ABIN1048984 IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-KCNH2 / Kv11.1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11至14个工作日
$484.00
详细
Cow 非结合性 IHC, IHC (p) Anti-KCNH2 / Kv11.1 antibody  ABIN1048985 IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-KCNH2 / Kv11.1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11至14个工作日
$484.00
详细
非结合性 FACS, WB Western blot analysis of KCNH2 Antibody (Center) (ABIN652759) in CEM cell line lysates (35 µg/lane).KCNH2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10至11个工作日
$335.50
详细
非结合性 EIA, WB Western blot analysis of KCNH2 Antibody (Center) in CEM cell line lysates (35ug/lane).KCNH2 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 WB Western blot analysis of extracts of various cell lines, using KCNH2 antibody. 100 μL Log in to see 16 Days
$334.02
详细
Cow 非结合性 IHC, IHC (p), WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细

引用最多的anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 抗体

  1. Dog (Canine) Polyclonal KCNH2 Primary Antibody for IF (p), IHC (p) - ABIN734843 : Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014 (PubMed)

更多抗Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2的相互作用对抗体

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. Data have defined the requirements for the susceptibility of LQT2 mutations to nonsense-mediated mRNA decay (NMD), and suggested that the majority of LQT2 nonsense and frameshift mutations are potential targets of NMD. Given that these specific mutations account for more than 30% of reported LQT2 mutations, the degradation of mutant mRNA by NMD is an important disease causing mechanism in the pathogenesis of LQT2.

  2. Applying the computational approaches in this study, have helped to elucidate the possible binding patterns and time evaluation dynamics of this drug at hERG1 channel models (both in its open and open-inactivated states) together with the crucial amino acid residues that mostly contribute in binding processes via interaction binding energy decomposition analysis.

  3. In a family afflicted by recurrent SIDS (显示 IDS 抗体), post-mortem directed genetic testing was conducted. We demonstrate that despite the variant being present in both SIDS (显示 IDS 抗体) cases, KCNH2-p.Pro963Thr did not appreciably alter membrane surface expression of the hERG channel, or the biophysical properties, including deactivation gating. These findings suggest that KCNH2-p.Pro963Thr is not a monogenic disease-causing LQTS mutation

  4. It was also found that drug ionization may play a crucial role in preferential targeting to the open-inactivated state of the pore domain. pH-dependent hERG blockade by dofetilie was studied with patch-clamp recordings. The results show that low pH increases the extent and speed of drug-induced block.

  5. Our results underscore the importance of careful characterization of the impact of epitope fusion tags and of confirming complete sequence accuracy prior to genotype-phenotype studies for ion channel proteins such as hERG.

  6. Data show that ether-a-go-go-related 1 (hERG1) ion channel expression knockdown elicited a reversion of the epithelial to the mesenchymal state (EMT (显示 ITK 抗体)) profile in colorectal cancer HCT116 cells with a reacquisition of the epithelial-like profile.

  7. TBX20 (显示 TBX20 抗体) can be considered a KCNH2-modifying gene.

  8. The KCNH2 intron 9 branch point is linked to the regulation of KCNH2 isoform expression in cardiomyocytes.

  9. Our findings suggest that the K897T polymorphism of KCNH2 may contribute to the occurrence of syncope in Andersen-Tawil syndrome.

  10. this study shows that hERG1 behaves as biomarker of progression to adenocarcinoma in Barrett's esophagus and can be exploited for a novel endoscopic surveillance

Guinea Pig Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. data suggest that CO induces arrhythmias in guinea pig cardiac myocytes via the ONOO(-)-mediated inhibition of Kv11.1 (显示 KCNV2 抗体) K(+) channels

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. PKD1 (显示 PKD1 抗体) mediates the PKC (显示 PKC 抗体) effects on KV11.1 (显示 KCNV2 抗体) and we found that PKD (显示 PRKD1 抗体) targets S284 in the N-terminus of the channel.

  2. histone H4 (显示 HIST1H4H 抗体) hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2 (显示 KCNJ2 抗体), Kcnj3 (显示 KCNJ3 抗体), Kcnj5 (显示 KCNJ5 抗体), Kcnj11 (显示 KCNJ11 抗体), and Kcnh2)

  3. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 (显示 NKX2-5 抗体) regulates the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 (显示 NKX2-5 抗体) dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  4. Report altered protein trafficking/function of mouse ERG K(+) channel clones.

  5. Enhancement of HERG protein expression through Hsp90 (显示 HSP90 抗体) inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins.

  6. The findings of this study suggested that MERG1a may not modulate Murf1 (显示 TRIM63 抗体) expression through the AKT (显示 AKT1 抗体)/FOXO (显示 FOXO3 抗体) pathway.

  7. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5 (显示 KCNA5 抗体). Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 (显示 KCNA5 抗体) as "ultra rapid" potassium channels.

  8. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 (显示 ASGR1 抗体) cells.

  9. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes.

  10. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia.

Rabbit Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. In transgenic long QT syndrome rabbits, Kv11.1 channel activation shortens the cardiac activation potential duration.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) 抗原简介

蛋白简介

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Gene names and symbols associated with KCNH2

  • potassium voltage-gated channel subfamily H member 2 (KCNH2) 抗体
  • potassium voltage-gated channel subfamily H member 2 (Kcnh2) 抗体
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2) 抗体
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2) 抗体
  • AI326795 抗体
  • cerg 抗体
  • derg 抗体
  • erg 抗体
  • erg1 抗体
  • gp-erg 抗体
  • HERG 抗体
  • HERG1 抗体
  • KCNH2 抗体
  • Kv11.1 抗体
  • LQT 抗体
  • Lqt2 抗体
  • M-erg 抗体
  • Merg1 抗体
  • merg1a 抗体
  • merg1b 抗体
  • SQT1 抗体

Protein level used designations for KCNH2

ERG-1 , H-ERG , eag homolog , eag-related protein 1 , ether-a-go-go-related gene potassium channel 1 , ether-a-go-go-related potassium channel protein , ether-a-go-go-related protein 1 , hERG-1 , potassium voltage-gated channel subfamily H member 2 , voltage-gated potassium channel subunit Kv11.1 , potassium voltage-gated channel, subfamily H (eag-related), member 2 , potassium channel protein ERG , potassium voltage-gated channel subfamily H member 2-like , c-ERG , eag related protein 1 , ether-a-go-go related gene potassium channel 1 , MERG , ether a go-go related , RERG , r-ERG , ERG1 , ra-erg , ventricular ERG K+ channel subunit , voltage-gated potassium channel 11.1 , voltage-gated potassium channel, subfamily H, member 2

GENE ID SPECIES
3757 Homo sapiens
463894 Pan troglodytes
100064000 Equus caballus
100135563 Cavia porcellus
100413935 Callithrix jacchus
100447585 Pongo abelii
403761 Canis lupus familiaris
16511 Mus musculus
117018 Rattus norvegicus
100009242 Oryctolagus cuniculus
100858122 Gallus gallus
100523293 Sus scrofa
539971 Bos taurus
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