Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 蛋白 (KCNE2)

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. 再加上,我们可以发KCNE2 抗体 (63)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
KCNE2 9992 Q9Y6J6
KCNE2 171138 P63161
KCNE2 246133 Q9D808
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50至55个工作日
$7,626.01
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
$5,355.45
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酵母菌 大鼠 His tag Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 (KCNE2) (AA 70-123) protein (His tag) expressed in E. coli 1 mg Log in to see 60至71个工作日
$2,031.33
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大肠杆菌(E. Coli) 大鼠 His tag 100 μg Log in to see 11 Days
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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酵母菌 豚鼠 His tag   1 mg Log in to see 60至71个工作日
$2,031.33
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酵母菌 His tag   1 mg Log in to see 60至71个工作日
$2,084.50
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KCNE2 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Rat (Rattus) ,

Mouse (Murine)

更多Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 (KCNE2)互动伙伴

Human Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 (KCNE2) interaction partners

  1. On the basis of clinical phenotype, the high allelic frequencies of LQT6 mutations in the Exome Aggregation Consortium database, and absence of previous documentation of genotype-phenotype segregation, our findings suggest that many KCNE2 variants, and perhaps all, have been erroneously designated as LQTS-causative mutations. Instead, KCNE2 variants may confer proarrhythmic susceptibility when provoked by additional envir

  2. These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin (显示 INS 蛋白) secretion, and that Kcne2 deletion causes T2DM.

  3. The identification of Filamin C (显示 FLNC 蛋白) as a novel KCNE2 ligand not only enhances current understanding of ion channel function and regulation, but also provides valuable information about possible pathways likely to be involved in long-QT syndrome pathogenesis

  4. KCNE2 has been widely studied since its role in the heart was discovered; it is association with inherited and acquired human Long QT syndrome; physiological analyses together with genetics studies have uncovered a startling array of functions for KCNE2, in the heart, stomach, thyroid and choroid plexus. [Review]

  5. Women with elevated BMI have enhanced hERG (显示 KCNH2 蛋白) activity as a result of low beta-inhibitory protein expression, which likely contributes to weak contractions and poor labour outcomes.

  6. M54T MiRP1 mutation axecerbate drug-induced long QT syndrome and arrhythmia.

  7. The effect of KCNE2 mutations on KV7.1 (显示 KCNQ1 蛋白) was abolished in the presence of the major IKs beta-subunit (显示 POLG 蛋白) KCNE1 (显示 KCNE1 蛋白), when coexpressed in a 1:1:1 molar ratio.

  8. Mutations in KCNE2 has been shown to cause familial atrial fibrillation.

  9. The transmembrane domains (TMDs) of KCNE1 (显示 KCNE1 蛋白) and KCNE2 were illustrated to associate with the KCNQ1 (显示 KCNQ1 蛋白) channel in different modes.

  10. study concluded that the variants in KCNQ1 (显示 KCNQ1 蛋白), KCNH2 (显示 KCNH2 蛋白), KCNE1 (显示 KCNE1 蛋白) and KCNE2 genes may be correlated with the occurrence of part of sudden unexplained nocturnal death syndrome cases in southern China

Mouse (Murine) Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 (KCNE2) interaction partners

  1. These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin (显示 INS 蛋白) secretion, and that Kcne2 deletion causes T2DM.

  2. Kcne2 deletion preconditions the heart, attenuating the acute tissue damage caused by an imposed ischaemia/reperfusion injury

  3. The data establish causality for the first example of ion channel-linked atherosclerosis, and demonstrate that the severity of Kcne2-linked cardiac arrhythmias is strongly diet-dependent.

  4. Endogenous KCNE2 in cardiomyocytes is important in maintaining cardiac electrical stability mainly by regulating Ito and action potential duration.

  5. Kcne2-deficient mice, in addition to the previously reported phenotypes, also present with iron-deficient anemia.

  6. KCNQ1 (显示 KCNQ1 蛋白), KCNE2, and SMIT1 (显示 SLC5A3 蛋白) form reciprocally regulating complexes that affect neuronal excitability.

  7. The Kcne2 Deletion suggest that a more holistic view of the pathogenesis of monogenic cardiac arrhythmias could provide a clearer picture of the mechanisms underlying sudden cardiac dealth.

  8. KCNE1 (显示 KCNE1 蛋白) and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 (显示 BACE 蛋白) and PS/gamma-secretase in cells.

  9. Loss of KCNE2 leads to downregulation of HCN channel function associated with increased excitability in neurons in the cortico-thalamo-cortical loop.

  10. KCNE2 influences blood-CSF (显示 CSF2 蛋白) anion flux by regulating KCNQ1 (显示 KCNQ1 蛋白) and KCNA3 (显示 KCNA3 蛋白) in the choroid plexus epithelium.

蛋白简介KCNE2

蛋白简介

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia.

Gene names and symbols associated with KCNE2

  • potassium voltage-gated channel subfamily E regulatory subunit 2 (KCNE2)
  • potassium voltage-gated channel subfamily E regulatory subunit 2 (Kcne2)
  • potassium voltage-gated channel, Isk-related subfamily, gene 2 (Kcne2)
  • 2200002I16Rik 蛋白
  • ATFB4 蛋白
  • AW048273 蛋白
  • LQT5 蛋白
  • LQT6 蛋白
  • MiRP1 蛋白

Protein level used designations for KCNE2

cardiac voltage-gated potassium channel accessory subunit 2 , minK-related peptide 1 , minK-related peptide-1 , minimum potassium ion channel-related peptide 1 , potassium channel subunit beta MiRP1 , potassium channel subunit, MiRP1 , potassium voltage-gated channel subfamily E member 2 , voltage-gated K+ channel subunit MIRP1 , potassium voltage-gated channel, Isk-related subfamily, gene 2 , MinK-related peptide 1 , potassium channel beta subunit , K+/pacemaker channel beta subunit mirp1 , minimum potassium ion channel related peptide 1

GENE ID SPECIES
9992 Homo sapiens
171138 Rattus norvegicus
403471 Canis lupus familiaris
768025 Bos taurus
100008804 Oryctolagus cuniculus
246133 Mus musculus
100725255 Cavia porcellus
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