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Several different potassium channels are known to be involved with electrical signaling in the nervous system.
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Increased excitability and decreased dendritic arborization are associated with downregulation of inward rectifier potassium channels (Kir2.1 (显示 KCNJ2 蛋白)/2.3).
Kir2.2 (显示 KCNJ12 蛋白) and Kir2.1 (显示 KCNJ2 蛋白) are primary determinants of endogenous K(+) conductance in HAECs under resting conditions and that Kir2.2 (显示 KCNJ12 蛋白) provides the dominant conductance in these cells.
Results describe the regulation of inwardly rectifying potassium current and its main molecular correlates, Kir2.1 (显示 KCNJ2 蛋白), Kir2.2 (显示 KCNJ12 蛋白) and Kir2.3 channels, by endothelin-1 (显示 EDN1 蛋白) in human atrial cardiomyocytes.
Kir2.3 is internalized by an AP-2 clathrin-dependent mechanism.
possibility of intramolecular interactions of the residue Kir2.3(H117) with conserved cysteines in close proximity to the selectivity filter
The data suggest that Kir2.3 plays a potentially important role in I(K1) currents in neonatal rat cardiomyocytes.
TIP-1 (显示 TAX1BP3 蛋白) may act as an important regulator for the endocytic pathway of Kir2.3.
changes in these proteins and their modification may predispose striatal projection neurons to dysfunction and then degeneratation in Huntington disease (显示 HTT 蛋白)
K+ currents attributable to Kir2.2 (显示 KCNJ12 蛋白)/2.3 and K+-selective leak (Kleak) channels are prominent in layer V-VI pyramidal neurons in slices of prelimbic and infralimbic cortex
Kir2.3 channels do not contribute to cardiac inward rectifier (显示 KCNJ5 蛋白) potassium currents.
Enhanced interaction with PIP(2) is the molecular mechanism for Kir2.3 channel activation by arachidonic acid.
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.
potassium inwardly-rectifying channel, subfamily J, member 4
, inward-rectifying potassium channel cKir2.3
, potassium inwardly-rectifying channel J4
, hippocampal inward rectifier potassium channel
, inward rectifier K(+) channel Kir2.3
, inward rectifier K+ channel Kir2.3
, inward rectifier potassium channel 4
, potassium channel, inwardly rectifying subfamily J member 4
, Kir 2.3
, brain inwardly rectifying K(+) channel 2