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subunit of RNA polymerase I [RGD, Feb 2006]..
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analyzed the kinetics of assembly and elongation of the RNA polymerase I (显示 POLR1C 抗体) complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy [RPA43]
Homozygous c.2801C>T (p.(Ser934Leu)) in POLR1A was identified in two brothers with unusual neurological disease that manifested with ataxia, psychomotor retardation, cerebellar and cerebral atrophy, and leukodystrophy.
Consistent with this observation, we discovered that polr1a mutant zebrafish exhibited cranioskeletal anomalies mimicking the human phenotype. polr1a loss of function led to perturbed ribosome biogenesis and p53 (显示 TP53 抗体)-dependent cell death
SIRT7 knockdown leads to reduced levels of RNA Pol I protein, but not messenger RNA
findings demonstrate that Bloom's syndrome helicase (BLM)interacts with RPA194; studies suggest that nucleolar BLM modulates rDNA structures in association with RNA polymerase I (显示 POLR1C 抗体) to facilitate RNA polymerase I (显示 POLR1C 抗体)-mediated rRNA transcription
Interference of POLR1A inhibited the synthesis of rRNA and hindered cell cycle progression in cells with inactivated p53 (显示 TP53 抗体), as a consequence of downregulation of the transcription factor E2F-1 (显示 E2F1 抗体).
subunit of RNA polymerase I
DNA-directed RNA polymerase I largest subunit
, DNA-directed RNA polymerase I subunit A
, DNA-directed RNA polymerase I subunit RPA1
, RNA polymerase 1-4 (194 kDa subunit)
, RNA polymerase I 194 kDa subunit
, RNA polymerase I subunit A1
, DNA-directed RNA polymerase I A
, RNA polymerase 1-4
, RNA polymerase I (194 kDa subunit)
, DNA-directed RNA polymerase I subunit A1