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PKD1L3 encodes a member of the polycystin protein family. 再加上，我们可以发PKD1L3 蛋白 (8)和数多这个蛋白质的别的产品。
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These results demonstrate that Asp (显示 C3 抗体)(523) in PKD2L1 (显示 PKD2L1 抗体) is a key determinant of Ca(2 (显示 CA2 抗体)+) permeation into the PKD1L3/PKD2L1 (显示 PKD2L1 抗体) complex and that PKD2L1 (显示 PKD2L1 抗体) contributes to forming the pore of the PKD1L3/PKD2L1 (显示 PKD2L1 抗体) channel.
results suggest that the interaction between PKD1L3 and PKD2L1 (显示 PKD2L1 抗体) through their transmembrane domains is essential for proper trafficking of the channels to the cell surface in taste cells of circumvallate and foliate papillae and in cultured cells
the PKD2L1 (显示 PKD2L1 抗体)-PKD1L3 complex is involved in acid sensing in vivo
genes are mapped to chromosomes and gene structures are characterized; protein structure is predicted and contains strong ion channel signature motifs that suggest their possible function as components of cation channel (显示 TRPV1 抗体) pores
Pkd1l3 and Pkd2l1 (显示 PKD2L1 抗体) are co-expressed in a select subset of taste receptor cells and therefore may, like other PKD (显示 PRKD1 抗体) channels, function as a heteromer
These results suggest that PKD1L3 and PKD2L1 (显示 PKD2L1 抗体) heteromers may function as sour taste receptors.
The off-response property of PKD1L3-PKD2L1 (显示 PKD2L1 抗体) channels might explain the physiological phenomena occurring during sour taste sensation.
PKD1L3-PKD2L1 (显示 PKD2L1 抗体) channel activation by acetic acid was pH-dependent and occurred when the ambient pH was <3.1.
our study identified C1 as the first PKD2L1 (显示 PKD2L1 抗体) domain essential for both PKD2L1 (显示 PKD2L1 抗体) trimerization and channel function, and suggest that PKD2L1 (显示 PKD2L1 抗体) and PKD2L1 (显示 PKD2L1 抗体)/PKD1L3 channels share the PKD2L1 (显示 PKD2L1 抗体) trimerization process.
functions as a channel-forming subunit in an acid-sensing heteromeric complex formed by PKD1L3 and TRPP3 (显示 PKD2L1 抗体)
Among the three gustatory regions innervated by peripheral gustatory neurons in the geniculate ganglion, transgenic Pkd1l3 is expressed in the foliate papillae, not in the fungiform papillae or palate.
This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.
PC1-like 3 protein
, polycystic kidney disease protein 1-like 3