Poly A Binding Protein Nuclear 1 蛋白 (PABPN1)

PABPN1 encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. 再加上,我们可以发Poly A Binding Protein Nuclear 1 抗体 (36)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
PABPN1 8106 Q86U42
PABPN1 54196 Q8CCS6
大鼠 PABPN1 PABPN1 116697  
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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PABPN1 蛋白 by Origin and Source

Origin 在表达 标记
Human ,

Mouse (Murine)

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Human Poly A Binding Protein Nuclear 1 (PABPN1) interaction partners

  1. The expression of Ala-expanded-PABPN1 causes the formation of nuclear aggregates before the onset of muscle weakness in oculopharyngeal muscular dystrophy.

  2. The purpose of this study was to characterize the type of PABPN1 expanded alleles in a large cohort of Oculopharyngeal muscular dystrophy individuals from Mexico.

  3. We propose that the extensive binding of CircPABPN1 to HuR (显示 ELAVL1 蛋白) prevents HuR (显示 ELAVL1 蛋白) binding to PABPN1 mRNA and lowers PABPN1 translation, providing the first example of competition between a circRNA and its cognate mRNA for an RBP (显示 RBP4 蛋白) that affects translation.

  4. Whereas PABPN1 strongly increases the activity of its cognate poly(A) polymerase (显示 PAPOLA 蛋白) in vitro, Pab2 was unable to stimulate Pla1 (显示 POU2F3 蛋白) to any significant extent.

  5. The described is the mRNA degradation poly(A) tail exosome targeting (PAXT) connection, which comprises the ZFC3H1 Zn-knuckle protein as a central link between MTR4 and the nuclear poly(A)-binding protein PABPN1.

  6. PABPN1 aggregates are able to trap TNNT3 pre-mRNA, driving it outside nuclear speckles, leading to an altered SC35 (显示 SRSF2 蛋白)-mediated splicing.

  7. The levels of these 6 cytokines were not altered in expPABPN1 carriers at a pre-symptomatic stage, suggesting that this group of cytokines is a potential biomarker for muscle weakness in OPMD. Correlation pattern of expression levels could be a novel measurer for disease state

  8. Large cohort study demonstrated that in heterozygous and homozygous patients with oculopharyngeal muscular dystrophy, the mean age at diagnosis and the severity of the clinical symptoms correlate to the number of PABPN1 (GCN) repeats. Homozygous patients showed the worse phenotype, suggesting a gene-dose effect in addition to the repeat number expansion.

  9. we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 and the poly(A)-specific RNase PARN (显示 PARN 蛋白).

  10. Many ribozymes were assayed and validated, including four ribozymes targeting the transcript of a disease-causing gene (a mutant version of PABPN1).

Cow (Bovine) Poly A Binding Protein Nuclear 1 (PABPN1) interaction partners

  1. PABPN1 measures the length of the tail and is responsible for disrupting the CPSF (显示 CPSF2 蛋白)-poly(A) polymerase (显示 PAPOLA 蛋白) interaction.

Mouse (Murine) Poly A Binding Protein Nuclear 1 (PABPN1) interaction partners

  1. PABPN1-17A gave rise to: inhibition of Ca2 (显示 CA2 蛋白)+ release during ECC, depletion of sarcoplasmic reticulum Ca2 (显示 CA2 蛋白)+ content, reduced expression of ryanodine receptors, altered nuclear morphology and incapability to stimulate myoblast fusion.

  2. Matrin 3 (MATR3 (显示 MATR3 蛋白)) is a novel protein interactor of PABPN1. MATR3 (显示 MATR3 蛋白) also binds and regulates the levels of long non-coding RNA (lncRNA) Neat1 and together with PABPN1 is required for normal paraspeckle function.

  3. Expression levels of these cytokines were highly correlated in controls, but this correlation pattern was disrupted in OPMD. The levels of these 6 cytokines were not altered in expPABPN1 carriers at a pre-symptomatic stage, suggesting that this group of cytokines is a potential biomarker for muscle weakness in OPMD.

  4. educed PABPN1 levels caused a consistent decline in distal PAS utilization in the 3'-UTR of a subset of OPMD-dysregulated genes. This alternative PAS utilization led to up-regulation of Atrogin-1, a key muscle atrophy regulator, but down regulation of proteasomal genes. Additionally reduced PABPN1 levels caused a reduction in proteasomal activity, and transition in MyHC isotope expression pattern in myofibers.

  5. PABPN1 interacts with and is stabilized by heat shock protein 90 (显示 HSP90 蛋白).

  6. These findings demonstrate a role for PABPN1 in rescuing several cytopathological features of TDP-43 (显示 TARDBP 蛋白) proteinopathy by increasing the turnover of pathologic proteins.

  7. the first step of the cleavage and polyadenylation reaction, mRNA cleavage, is affected in muscles expressing alanine-expanded PABPN1. We propose that impaired cleavage is an early defect in Oculopharyngeal muscular dystrophy.

  8. These results suggest that PABPN1 levels regulate muscle cell aging and oculopharyngeal muscular dystrophy represents an accelerated muscle aging disorder.

  9. tristetraprolin (显示 ZFP36 蛋白) inhibits poly(A) tail synthesis by interacting with poly(A)-binding protein nuclear 1 in the nucleus to regulate expression of AU-rich element-containing mRNA

  10. PABPN1 plays an essential role in myoblast proliferation and differentiation, suggesting that it is required for muscle regeneration and maintenance in vivo.

Arabidopsis thaliana Poly A Binding Protein Nuclear 1 (PABPN1) interaction partners

  1. Poly(A) Binding Protein binds to uridylated oligo(A) tails and determines the length of U-extensions added by URT1.

  2. PAB2 was partially retargeted to the nucleolus in the presence of TuMV VPg-Pro. In addition, the membrane association of PAB2 during TuMV infection resulted from the internalization of the host protein in 6K-VPg-Pro-induced vesicles.

  3. Thus, Hsc70-3 and PABP2 are potentially integral components of the replicase complex and could have important roles to play in the regulation of potyviral RdRp functions.

蛋白简介Poly A Binding Protein Nuclear 1 (PABPN1)

蛋白简介

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

Gene names and symbols associated with PABPN1

  • poly(A) binding protein nuclear 1 (PABPN1)
  • poly(A) binding protein, nuclear 1 (Pabpn1)
  • poly(A) binding protein 2 (PAB2)
  • ARABIDOPSIS POLY(A) BINDING 2 蛋白
  • ATPAB2 蛋白
  • F28A23.130 蛋白
  • F28A23_130 蛋白
  • mPABII 蛋白
  • OPMD 蛋白
  • PAB2 蛋白
  • PABII 蛋白
  • PABP-2 蛋白
  • PABP2 蛋白
  • Pabp3 蛋白
  • POLY(A)-BINDING PROTEIN 2 蛋白
  • poly(A) binding protein 2 蛋白

Protein level used designations for PABPN1

poly(A) binding protein 2 , poly(A) binding protein II , polyadenylate-binding protein 2 , PABII , PABP-2 , nuclear poly(A)-binding protein 1 , poly(A)-binding protein 2 , poly(A)-binding protein II , polyadenylate-binding nuclear protein 1

GENE ID SPECIES
8106 Homo sapiens
100170671 Canis lupus familiaris
282298 Bos taurus
54196 Mus musculus
116697 Rattus norvegicus
829557 Arabidopsis thaliana
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