anti-Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) 抗体

PABPC1 encodes a poly(A) binding protein. 再加上,我们可以发Poly(A) Binding Protein, Cytoplasmic 1 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PABPC1 26986 P11940
PABPC1 18458 P29341
PABPC1 171350 Q9EPH8
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Showing 10 out of 78 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB WB Suggested Anti-PABPC1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  HepG2 cell lysate Sample Type :  Human brain stem cells (NT2)   Primary Antibody Dilution :   1:500  Secondary Antibody :  Goat anti-rabbit Alexa Fluor 594  Secondary Antibody Dilution :   1:1000  Color/Signal Descriptions :  Red: PABPC1 Blue: DAPI  Gene Name :  PABPC1  Submitted by :  Dr. Yuzhi Chen, University of Arkansas for Medical Science 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 小鼠 非结合性 CyTOF, ELISA, FACS, ICC, IF, IP, MA, WB Western Blot: PABP Antibody (10E10) [ABIN267505] - Cell line lysates were separated on SDS-PAGE and probed with 1 ug/mL Monoclonal Anti-PABP Clone: 10E10. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate. (1) HEK293T, (2) HeLa, (3) G361 and (4) COS-7. Immunocytochemistry/Immunofluorescence: PABP Antibody (10E10) [ABIN267505] - PABP antibody was tested in HeLa cells at a 1:50 dilution using a Dylight 488 conjugated secondary antibody (Green). Actin (Red) and DNA (Blue) were counterstained using Phalloidin 568 and DAPI. 0.1 mL Log in to see 7至9个工作日
$488.73
详细
非结合性 IHC (p), WB Western blot analysis of PABPC1 Antibody (Center) (ABIN389462) in NIH-3T3 cell line lysates (35 µg/lane). PABPC1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10至11个工作日
$385.00
详细
非结合性 IHC (p), WB IHC-P Image PABP antibody [N1N2], N-term detects PABP protein at cytosol on mouse lung by immunohistochemical analysis. Sample: Paraffin-embedded mouse lung. PABP antibody [N1N2], N-term , dilution: 1:500. IHC-P Image PABP antibody [N1N2], N-term detects PABP protein at cytosol on mouse duodenum by immunohistochemical analysis. Sample: Paraffin-embedded mouse duodenum. PABP antibody [N1N2], N-term , dilution: 1:500. 100 μL Log in to see 3至4个工作日
$466.18
详细
非结合性 ELISA, WB Western blot analysis of Phospho-PABP1(Tyr364) in lysates of HCT116?, using Phospho-PABP1(Tyr364) Antibody(ABIN6267887). 100 μL Log in to see 11至12个工作日
$450.00
详细
非结合性 IHC (p), WB Immunohistochemistry-Paraffin: PABP Antibody  - Staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts. Western Blot: PABP Antibody  250, 130, 95, 72, 55, 36, 28, 17, 10 Lane 2: Human cell line RT-4 100 μL Log in to see 10至13个工作日
$494.38
详细
小鸡 非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
详细
非结合性 ELISA, WB Western blot analysis of PABP1 in lysates of HT-29, using PABP1 Antibody(ABIN6268303). 100 μL Log in to see 11至12个工作日
$450.00
详细
小鸡 小鼠 非结合性 ICC, FACS, IF, IP, ELISA, WB Western blot for anti-PABP on HeLa cell extracts (left lane) 50 μL Log in to see 7至8个工作日
$447.65
详细
非结合性 EIA, WB Western blot analysis of PABPC1 Antibody (Center) in NIH-3T3 cell line lysates (35ug/lane). PABPC1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6至8个工作日
$390.50
详细

引用最多的anti-Poly(A) Binding Protein, Cytoplasmic 1 抗体

  1. Cow (Bovine) Monoclonal PABPC1 Primary Antibody for CyTOF, ELISA - ABIN267505 : Lee, Bedford: PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. in EMBO reports 2002 (PubMed)
    Show all 7 Pubmed References

  2. Chicken Monoclonal PABPC1 Primary Antibody for ICC, FACS - ABIN108539 : Görlach, Burd, Dreyfuss: The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity. in Experimental cell research 1994 (PubMed)
    Show all 3 Pubmed References

  3. Chicken Monoclonal PABPC1 Primary Antibody for ICC, FACS - ABIN108538 : Gorgoni, Richardson, Burgess, Anderson, Wilkie, Gautier, Martins, Brook, Sheets, Gray: Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 3 Pubmed References

  4. Monoclonal PABPC1 Primary Antibody for IF, IP - ABIN534185 : Hofmann, Casella, Schnölzer, Schlechter, Spring, Franke: Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. in Molecular biology of the cell 2006 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal PABPC1 Primary Antibody for IF, WB - ABIN525792 : Higashi, Tomigahara, Shiraki, Miyata, Mikami, Kimura, Moro, Inagaki, Kaneko: A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice. in The Journal of biological chemistry 2011 (PubMed)

更多抗Poly(A) Binding Protein, Cytoplasmic 1的相互作用对抗体

Human Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) interaction partners

  1. Study characterized the structure of multiple PABPC1 molecules bound to a long poly(A) chain as constituting a one-dimensional wormlike form. These interactions responsible for PABPC1 multimerization occur at residues in the linker region and the RNA recognition motif 2, and shown that such interaction is important for translational activity.

  2. The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 acts as an energy sensor and negatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1.

  3. Epstein-Barr Virus protein EB2 first is recruited to the mRNA cap structure in the nucleus and then interacts with the proteins eIF4G and PABP to enhance the initiation step of translation.

  4. These findings identify PABPC1 as a direct regulator of cardiac hypertrophy and define a new paradigm of gene regulation in the heart, where controlled changes in poly(A) tail length influence mRNA translation.

  5. Data suggest that DEAD-box helicase 3 (DDX3X) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (via gene silencing with the CRISPR-Cas system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line.

  6. Data suggest that hnRNPLL specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL = heterogeneous nuclear ribonucleoprotein L-like protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)

  7. PABP enhances the productive binding of the eRF1-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a which itself has an active role in translation termination.

  8. Unr stimulated the binding of PABP1 to mRNA, and that Unr was required for the stable interaction of PABP1 and eIF4G in cells.

  9. PABPC1 decreased expression in in infertile men with non-obstructive azoospermia

  10. BTG2 stimulates mRNA deadenylation via CAF1 activation through interaction with PABPC1. Interaction of BTG2 with the first RRM domain of PABPC1 is required for BTG2 to control cell proliferation.

  11. PABPC1 is a novel co-regulator of the AR

  12. PABPC1 is upregulated in gastric carcinoma tissues, and high PABPC1 expression predicts poor survival. PABPC1 regulates proliferation and transformation of gastric cancer cells in vitro and in vivo. PABPC1 knockdown induces apoptosis.

  13. PABPC1 interacts with AGO2 and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma.

  14. Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus

  15. Metastatic duodenal cancer cells do not tolerate intracellular PABP1 accumulation and are thus exported into the extracellular milieu by the exosome-mediated pathway. In addition, PABP1 has a potential use as a biomarker for metastatic duodenal cancer.

  16. This study highlights PABP-1 as a protein that is important to the pathology of ALS and indicates that the proteomic profile of TDP-43 inclusions in ALS may differ depending on the causative genetic mutation.

  17. PABPC1 is mislocalized in spinal cord motor neurons in amyotrophic lateral sclerosis.

  18. Study shows that PABP specifically regulates iNOS mRNA stability in human DLD-1 cells by binding to different sites in the 50- and 30-UTR of the iNOS mRNA. .

  19. These results suggest that production of the NSs protein during rift valley fever virus infection leads to sequestration of PABP1 in the nuclear speckles, creating a state within the cell that favors viral protein production.

  20. These data indicate that PABPC1 is an important cellular target of human herpesvirus 8 ORF57 to directly upregulate polyadenylated nuclear RNA accumulation during viral lytic infection.

Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) 抗原简介

蛋白简介

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation\; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.

Gene names and symbols associated with PABPC1

  • poly(A) binding protein cytoplasmic 1 (PABPC1) 抗体
  • poly(A) binding protein, cytoplasmic 1 (Pabpc1) 抗体
  • poly(A) binding protein, cytoplasmic 1 S homeolog (pabpc1.S) 抗体
  • poly(A) binding protein, cytoplasmic 1 (pabpc1) 抗体
  • poly(A) binding protein cytoplasmic 1 like (PABPC1L) 抗体
  • poly(A) binding protein, cytoplasmic 1 L homeolog (pabpc1.L) 抗体
  • poly(A) binding protein, cytoplasmic 1a (pabpc1a) 抗体
  • poly(A) binding protein cytoplasmic 1 (Pabpc1) 抗体
  • ePAB 抗体
  • pab1 抗体
  • pabp 抗体
  • pabp1 抗体
  • PABPC1 抗体
  • pabpc2 抗体
  • PabpI 抗体
  • Pabpl1 抗体
  • wu:fb16a02 抗体
  • wu:fi19b08 抗体
  • wu:fj12d09 抗体
  • wu:fj61f06 抗体
  • zgc:109879 抗体

Protein level used designations for PABPC1

poly(A) binding protein, cytoplasmic 2 , polyadenylate-binding protein 1 , PABP-1 , poly A binding protein 1 , poly(A)-binding protein 1 , PABP 1 , PABP 1-A , PABP-1-A , PABP-A , cytoplasmic poly(A)-binding protein 1-A , poly(A)-binding protein 1-A , polyadenylate-binding protein 1-A , xPABP1-A , poly(A) binding protein, cytoplasmic 1 , polyadenylate-binding protein 1-like , PABP 1-B , PABP-1-B , PABP-B , cytoplasmic poly(A)-binding protein 1-B , poly(A)-binding protein 1-B , polyadenylate-binding protein 1-B , xPABP1-B

GENE ID SPECIES
26986 Homo sapiens
18458 Mus musculus
171350 Rattus norvegicus
379896 Xenopus laevis
448595 Xenopus (Silurana) tropicalis
612751 Canis lupus familiaris
711882 Macaca mulatta
430997 Gallus gallus
282296 Bos taurus
432140 Xenopus laevis
606498 Danio rerio
100727743 Cavia porcellus
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