anti-Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) 抗体

PABPC1 encodes a poly(A) binding protein. 再加上,我们可以发Poly(A) Binding Protein, Cytoplasmic 1 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PABPC1 26986 P11940
PABPC1 18458 P29341
PABPC1 171350 Q9EPH8
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antibodies-online.cn销售最多的anti-Poly(A) Binding Protein, Cytoplasmic 1 抗体

Showing 10 out of 79 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB WB Suggested Anti-PABPC1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  HepG2 cell lysate Sample Type :  Human brain stem cells (NT2)   Primary Antibody Dilution :   1:500  Secondary Antibody :  Goat anti-rabbit Alexa Fluor 594  Secondary Antibody Dilution :   1:1000  Color/Signal Descriptions :  Red: PABPC1 Blue: DAPI  Gene Name :  PABPC1  Submitted by :  Dr. Yuzhi Chen, University of Arkansas for Medical Science 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 小鼠 非结合性 CyTOF, ELISA, FACS, ICC, IF, IP, MA, WB Western Blot: PABP Antibody (10E10) [ABIN267505] - Cell line lysates were separated on SDS-PAGE and probed with 1 ug/mL Monoclonal Anti-PABP Clone: 10E10. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate. (1) HEK293T, (2) HeLa, (3) G361 and (4) COS-7. Immunocytochemistry/Immunofluorescence: PABP Antibody (10E10) [ABIN267505] - PABP antibody was tested in HeLa cells at a 1:50 dilution using a Dylight 488 conjugated secondary antibody (Green). Actin (Red) and DNA (Blue) were counterstained using Phalloidin 568 and DAPI. 0.1 mL Log in to see 7至9个工作日
$485.88
详细
非结合性 IHC (p), WB Western blot analysis of PABPC1 Antibody (Center) (ABIN389462) in NIH-3T3 cell line lysates (35 µg/lane). PABPC1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10至11个工作日
$335.50
详细
非结合性 IHC (p), WB IHC-P Image PABP antibody [N1N2], N-term detects PABP protein at cytosol on mouse lung by immunohistochemical analysis. Sample: Paraffin-embedded mouse lung. PABP antibody [N1N2], N-term , dilution: 1:500. IHC-P Image PABP antibody [N1N2], N-term detects PABP protein at cytosol on mouse duodenum by immunohistochemical analysis. Sample: Paraffin-embedded mouse duodenum. PABP antibody [N1N2], N-term , dilution: 1:500. 100 μL Log in to see 1至2个工作日
$358.60
详细
非结合性 IHC (p), WB Immunohistochemistry-Paraffin: PABP Antibody  - Staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts. Western Blot: PABP Antibody  250, 130, 95, 72, 55, 36, 28, 17, 10 Lane 2: Human cell line RT-4 100 μL Log in to see 10至13个工作日
$491.63
详细
小鸡 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
小鸡 小鼠 非结合性 ICC, FACS, IF, IP, ELISA, WB Western blot for anti-PABP on HeLa cell extracts (left lane) 50 μL Log in to see 7至8个工作日
$455.57
详细
非结合性 EIA, WB Western blot analysis of PABPC1 Antibody (Center) in NIH-3T3 cell line lysates (35ug/lane). PABPC1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
小鸡 小鼠 非结合性 IF, IP, ELISA, WB 50 μL Log in to see 7至9个工作日
$573.83
详细
非结合性 FACS, IF, IHC, WB 100 μL Log in to see 16 Days
$476.15
详细

引用最多的anti-Poly(A) Binding Protein, Cytoplasmic 1 抗体

  1. Cow (Bovine) Monoclonal PABPC1 Primary Antibody for CyTOF, ELISA - ABIN267505 : Lee, Bedford: PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. in EMBO reports 2002 (PubMed)
    Show all 7 Pubmed References

  2. Chicken Monoclonal PABPC1 Primary Antibody for ICC, FACS - ABIN108538 : Görlach, Burd, Dreyfuss: The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity. in Experimental cell research 1994 (PubMed)
    Show all 3 Pubmed References

  3. Chicken Monoclonal PABPC1 Primary Antibody for ICC, FACS - ABIN108539 : Gorgoni, Richardson, Burgess, Anderson, Wilkie, Gautier, Martins, Brook, Sheets, Gray: Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal PABPC1 Primary Antibody for IF, WB - ABIN525792 : Higashi, Tomigahara, Shiraki, Miyata, Mikami, Kimura, Moro, Inagaki, Kaneko: A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice. in The Journal of biological chemistry 2011 (PubMed)

更多抗Poly(A) Binding Protein, Cytoplasmic 1的相互作用对抗体

Human Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) interaction partners

  1. The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 (显示 SIRT1 抗体) acts as an energy sensor and negatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1.

  2. Epstein-Barr Virus protein EB2 first is recruited to the mRNA cap structure in the nucleus and then interacts with the proteins eIF4G and PABP to enhance the initiation step of translation.

  3. These findings identify PABPC1 as a direct regulator of cardiac hypertrophy and define a new paradigm of gene regulation in the heart, where controlled changes in poly(A) tail length influence mRNA translation.

  4. Data suggest that DEAD-box helicase 3 (DDX3X (显示 DDX3X 抗体)) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein (显示 BLZF1 抗体) 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (显示 DDX3X 抗体) (via gene silencing with the CRISPR-Cas (显示 CSE1L 抗体) system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line.

  5. Data suggest that hnRNPLL (显示 HNRPLL 抗体) specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL (显示 HNRPLL 抗体) to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL (显示 HNRPLL 抗体) = heterogeneous nuclear ribonucleoprotein L-like (显示 HNRPLL 抗体) protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)

  6. PABP enhances the productive binding of the eRF1 (显示 ZFP36L1 抗体)-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a (显示 GSPT1 抗体) which itself has an active role in translation termination.

  7. Unr (显示 P2RY4 抗体) stimulated the binding of PABP1 to mRNA, and that Unr (显示 P2RY4 抗体) was required for the stable interaction of PABP1 and eIF4G (显示 EIF4G1 抗体) in cells.

  8. PABPC1 decreased expression in in infertile men with non-obstructive azoospermia

  9. BTG2 (显示 BTG2 抗体) stimulates mRNA deadenylation via CAF1 (显示 CHAF1B 抗体) activation through interaction with PABPC1. Interaction of BTG2 (显示 BTG2 抗体) with the first RRM domain of PABPC1 is required for BTG2 (显示 BTG2 抗体) to control cell proliferation.

  10. PABPC1 is a novel co-regulator of the AR

Mouse (Murine) Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) interaction partners

  1. The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 (显示 SIRT1 抗体) acts as an energy sensor and negatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1.

  2. These results suggest that PABP (显示 EBP 抗体) interacts with HuD (显示 ELAVL4 抗体) in basal glucose conditions making translation inhibitory complex, however upon glucose stimulation this association is affected and PABP (显示 EBP 抗体) is acted upon by PDI (显示 PDIA3 抗体) resulting in stimulation of insulin (显示 INS 抗体) translation.

  3. These results demonstrate that EPAB is important for oocyte-somatic communication by maintaining transzonal processes and gap junctions at the preantral stage of folliculogenesis.

  4. The authors found that the endogenous Zfp36 (显示 ZFP36 抗体) directly interacts with the cytoplasmic poly(A)-binding protein. Importantly, this interaction is required for the translational repression of Zfp36 (显示 ZFP36 抗体)'s target mRNAs in resolving inflammation.

  5. Data suggest that hnRNPLL (显示 HNRPLL 抗体) specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL (显示 HNRPLL 抗体) to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL (显示 HNRPLL 抗体) = heterogeneous nuclear ribonucleoprotein L-like (显示 HNRPLL 抗体) protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)

  6. Superovulation with low or high doses of gonadotropins significantly altered Epab and Pabpc1 mRNA levels in GV oocytes, MII oocytes and 1- and 2-cell embryos compared with their respective controls. These changes most likely lead to variations in expression of EPAB- and PABPC1-regulated genes, which may adversely influence the quality of oocytes and early embryos retrieved using superovulation.

  7. Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr (显示 EGFR 抗体) signaling.

  8. Epab(-/-) oocytes are smaller in size, contain peripheral germinal vesicles, and are loosely associated with cumulus cells

  9. These findings suggest that EPAB may predominantly play roles in translational regulation of the mRNAs during early oogenesis and folliculogenesis, but PABPC1 most likely perform these roles in the later terms of ovarian development along with EPAB

  10. Epab is dispensable for mouse spermatogenesis and male fertility.

Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) 抗原简介

蛋白简介

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation\; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.

Gene names and symbols associated with PABPC1

  • poly(A) binding protein cytoplasmic 1 (PABPC1) 抗体
  • poly(A) binding protein, cytoplasmic 1 (Pabpc1) 抗体
  • poly(A) binding protein, cytoplasmic 1 S homeolog (pabpc1.S) 抗体
  • poly(A) binding protein, cytoplasmic 1 (pabpc1) 抗体
  • poly(A) binding protein cytoplasmic 1 like (PABPC1L) 抗体
  • poly(A) binding protein, cytoplasmic 1 L homeolog (pabpc1.L) 抗体
  • poly(A) binding protein, cytoplasmic 1a (pabpc1a) 抗体
  • poly(A) binding protein cytoplasmic 1 (Pabpc1) 抗体
  • ePAB 抗体
  • pab1 抗体
  • pabp 抗体
  • pabp1 抗体
  • PABPC1 抗体
  • pabpc2 抗体
  • PabpI 抗体
  • Pabpl1 抗体
  • wu:fb16a02 抗体
  • wu:fi19b08 抗体
  • wu:fj12d09 抗体
  • wu:fj61f06 抗体
  • zgc:109879 抗体

Protein level used designations for PABPC1

poly(A) binding protein, cytoplasmic 2 , polyadenylate-binding protein 1 , PABP-1 , poly A binding protein 1 , poly(A)-binding protein 1 , PABP 1 , PABP 1-A , PABP-1-A , PABP-A , cytoplasmic poly(A)-binding protein 1-A , poly(A)-binding protein 1-A , polyadenylate-binding protein 1-A , xPABP1-A , poly(A) binding protein, cytoplasmic 1 , polyadenylate-binding protein 1-like , PABP 1-B , PABP-1-B , PABP-B , cytoplasmic poly(A)-binding protein 1-B , poly(A)-binding protein 1-B , polyadenylate-binding protein 1-B , xPABP1-B

GENE ID SPECIES
26986 Homo sapiens
18458 Mus musculus
171350 Rattus norvegicus
379896 Xenopus laevis
448595 Xenopus (Silurana) tropicalis
612751 Canis lupus familiaris
711882 Macaca mulatta
430997 Gallus gallus
282296 Bos taurus
432140 Xenopus laevis
606498 Danio rerio
100727743 Cavia porcellus
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