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PSD encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor.
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Arf GTPases are likely to be locally activated by EFA6 and in turn targeted to the Flemming body to complete cytokinesis.
PSD expression might be a useful biomarker for epigenetic-based gastric cancer early diagnosis and may lead to the identification of new targets for pharmacological intervention.
EFA6 is regulated by a negative feedback loop, which is mediated by an allosteric interaction of Arf6 (显示 ARF6 抗体)-GTP (显示 AK3 抗体) with a domain of EFA6 and monitors the activation of Arf1 (显示 ARF1 抗体) and Arf6 (显示 ARF6 抗体) differentially
EFA6 participates in activation of Arf6 (显示 ARF6 抗体) around the cleavage furrow during cytokinesis.
Aberrant methylation of PSD occurs in UC-associated colorectal mucosa, enabling circumvention of Rac1 immune responses governing neutrophil chemotaxis and apoptosis, and plays a pivotal role in the mechanisms underlying UC-associated carcinogenesis.
Both levels of accumulation of F-actin and apoptosis were significantly decreased in specimens from UC patients with PSD methylation compared to those without PSD methylation.
Pleckstrin (显示 PLEK 抗体) is a critical molecule for proinflammatory cytokine secretion in response to elevated advanced glycation end products (AGE) in diabetes.
Arf6 exchange factor EFA6 and endophilin directly interact at the plasma membrane to control clathrin-mediated endocytosis.
EFA6A regulates Arf6 (显示 ARF6 抗体)-mediated neurite formation through interaction with SNX1 (显示 SNX1 抗体).
determined the complete primary sequence of mouse EFA6D (显示 PSD3 抗体) encoding a protein of 1004 amino acids with a calculated molecular weight of 111,207 Da.
EFA6A may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines
EFA6A-ARF6 (显示 ARF6 抗体) pathway may play a specific role at a subcompartment of perisynaptic photoreceptor processes
Results showed that EFA6A was first shown localized intensely in nuclei of spermatocytes of adult testes and suggested a possible involvement of EFA6A-ARF6 (显示 ARF6 抗体) signaling in the karyokinesis and cytokinesis.
This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants.
PH and SEC7 domain-containing protein 1
, exchange factor for ARF6
, pleckstrin homology and SEC7 domain-containing protein 1
, pleckstrin-Sec7 domains-containing
, pleckstrin and Sec7 domain containing homolog