Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) ELISA试剂盒

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). 再加上,我们可以发Pleckstrin Homology Domain Containing, Family O Member 1 抗体 (56)Pleckstrin Homology Domain Containing, Family O Member 1 蛋白 (7)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
PLEKHO1 51177 Q53GL0
PLEKHO1 67220 Q9JIY0
PLEKHO1 310674 Q5BJM5
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适于 Pleckstrin Homology Domain Containing, Family O Member 1 相互作用对的更多 ELISA 试剂盒

Human Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations.

  2. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.

  3. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.

  4. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  5. High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.

  6. New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL.

  7. There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (显示 PAK1 ELISA试剂盒) for neoplastic prostate cells transformation.

  8. CKIP-1 interacts with CARMA1 and has an inhibitory effect on PKCtheta (显示 PRKCQ ELISA试剂盒);-CBM-NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling.

  9. CKIP-1 controlled Smurf1 (显示 SMURF1 ELISA试剂盒) expression in colon cancer

  10. overexpression triggers classical monocyte activation and transactivation of the TNF (显示 TNF ELISA试剂盒) promoter

Mouse (Murine) Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. The aim of this study was to investigate the effect of constrained dynamic loading (Loading) in combination with CKIP1 gene knockout (KO) on unloadinginduced bone loss in tailsuspension mice.

  2. the reduced bone formation in GIO mice could not only be prevented by osteoblasts-specific Ckip-1 ablation, but also be attenuated after osteoblasts-specific Smad1 (显示 SMAD1 ELISA试剂盒) overexpression

  3. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.

  4. PD increased CKIP-1 and Nrf2 (显示 NFE2L2 ELISA试剂盒) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (显示 ICAM1 ELISA试剂盒)

  5. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.

  6. The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 (显示 MAPK8 ELISA试剂盒) phosphorylation and further upregulating IRS-1 (显示 IRS1 ELISA试剂盒) phosphorylation and RI.

  7. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  8. Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1 (显示 ICAM1 ELISA试剂盒)) and fibronectin (显示 FN1 ELISA试剂盒) plus activation of Nrf2 (显示 NFE2L2 ELISA试剂盒)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.

  9. the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis

  10. CKIP-1 is a novel inhibitor of MSC (显示 MSC ELISA试剂盒)-originated adipogenesis by enhancing HDAC1 (显示 HDAC1 ELISA试剂盒)-associated repression of C/EBPalpha (显示 CEBPA ELISA试剂盒).

Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) 抗原简介

Antigen Summary

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).

Gene names and symbols associated with PLEKHO1

  • pleckstrin homology domain containing O1 (PLEKHO1) 抗体
  • pleckstrin homology domain containing, family O member 1 (Plekho1) 抗体
  • pleckstrin homology domain containing O1 (Plekho1) 抗体
  • pleckstrin homology domain containing, family O member 1a (plekho1a) 抗体
  • 2810052M02Rik 抗体
  • ckip-1 抗体
  • Ckip1 抗体
  • JZA-20 抗体
  • Jza2 抗体
  • OC120 抗体
  • plekho1 抗体
  • RGD1311487 抗体
  • si:dkey-200h23.2 抗体

Protein level used designations for PLEKHO1

2810052M02Rik , C-Jun-binding protein , CK2 interacting protein 1; HQ0024c protein , CK2-interacting protein 1 , JBP , OC120 , PH domain-containing family O member 1 , casein kinase 2-interacting protein 1 , osteoclast maturation-associated gene 120 protein , pleckstrin homology domain-containing family O member 1 , pleckstrin homology domain containing, family O member 1 , CK2 interacting protein 1 , Jun zipper-associated 2 , TNF intracellular domain-interacting protein , CK2-interacting protein-1 , PH domain-containing family O member 1-A , pleckstrin homology domain-containing family O member 1-A

GENE ID SPECIES
51177 Homo sapiens
426108 Gallus gallus
457268 Pan troglodytes
607927 Canis lupus familiaris
706145 Macaca mulatta
788251 Bos taurus
100152184 Sus scrofa
100347162 Oryctolagus cuniculus
100444299 Pongo abelii
67220 Mus musculus
310674 Rattus norvegicus
563283 Danio rerio
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