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Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). 再加上，我们可以发Pleckstrin Homology Domain Containing, Family O Member 1 试剂盒 (11) 和 Pleckstrin Homology Domain Containing, Family O Member 1 蛋白 (7)和数多这个蛋白质的别的产品。
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we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations.
we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.
these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.
the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.
High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.
New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL (显示 RTEL1 抗体)) and targeting CKIP-1 may be a novel therapeutic target for NHL (显示 RTEL1 抗体).
There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (显示 PAK1 抗体) for neoplastic prostate cells transformation.
CKIP-1 interacts with CARMA1 (显示 CARD11 抗体) and has an inhibitory effect on PKCtheta (显示 PRKCQ 抗体);-CBM-NF-kappaB (显示 NFKB1 抗体) signaling.
CKIP-1 controlled Smurf1 (显示 SMURF1 抗体) expression in colon cancer
overexpression triggers classical monocyte activation and transactivation of the TNF (显示 TNF 抗体) promoter
PD increased CKIP-1 and Nrf2 (显示 NFE2L2 抗体) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (显示 ICAM1 抗体)
The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 (显示 MAPK8 抗体) phosphorylation and further upregulating IRS-1 (显示 IRS1 抗体) phosphorylation and RI.
Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1 (显示 ICAM1 抗体)) and fibronectin (显示 FN1 抗体) plus activation of Nrf2 (显示 NFE2L2 抗体)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.
the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis
CKIP-1 is a novel inhibitor of MSC (显示 MSC 抗体)-originated adipogenesis by enhancing HDAC1 (显示 HDAC1 抗体)-associated repression of C/EBPalpha (显示 CEBPA 抗体).
CKIP-1 interacts with TRAF6 (显示 TRAF6 抗体), a ubiquitin ligase (显示 RNF123 抗体) required for K63-linked ubiquitination and plasma membrane recruitment of Akt (显示 AKT1 抗体), and terminates TRAF6 (显示 TRAF6 抗体)-mediated Akt (显示 AKT1 抗体) activation.
Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).
, C-Jun-binding protein
, CK2 interacting protein 1; HQ0024c protein
, CK2-interacting protein 1
, PH domain-containing family O member 1
, casein kinase 2-interacting protein 1
, osteoclast maturation-associated gene 120 protein
, pleckstrin homology domain-containing family O member 1
, pleckstrin homology domain containing, family O member 1
, CK2 interacting protein 1
, Jun zipper-associated 2
, TNF intracellular domain-interacting protein
, CK2-interacting protein-1
, PH domain-containing family O member 1-A
, pleckstrin homology domain-containing family O member 1-A