anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) 抗体

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). 再加上,我们可以发Pleckstrin Homology Domain Containing, Family O Member 1 试剂盒 (11)Pleckstrin Homology Domain Containing, Family O Member 1 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PLEKHO1 51177 Q53GL0
PLEKHO1 67220 Q9JIY0
PLEKHO1 310674 Q5BJM5
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Showing 10 out of 56 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-PLEKHO1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  COLO205 cell lysate WB Suggested Anti-PLEKHO1 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: COLO205 cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 FACS, IHC (p), WB Western blot analysis of CKIP-1 Antibody (N-term) (ABIN652439) in 293 cell line lysates (35 µg/lane). CKIP-1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human skeletal muscle reacted with CKIP-1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10至11个工作日
$335.50
详细
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
详细
非结合性 ELISA, IHC, IHC (p), WB Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-PLEKHO1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11至14个工作日
$484.00
详细
非结合性 EIA, WB   0.1 mg Log in to see 8至11个工作日
$474.10
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti CKIP-1 Polyclonal Antibody, Unconjugated (ABIN675039) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: mouse heart lysates Lane 2: mouse kidney lysates probed with Anti CKIP-1 Polyclonal Antibody, Unconjugated (ABIN675039) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 45kD. Observed band size: 45kD. 100 μL Log in to see 3至7个工作日
$306.90
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小鼠 非结合性 ELISA, IHC, IHC (p) 100 μg Log in to see 11至14个工作日
$537.17
详细
非结合性 IHC (p), ELISA, WB 50 μg Log in to see 12至14个工作日
$685.40
详细
非结合性 EIA, IHC (p), WB Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of CKIP1 in human lung tissue lysate with CKIP1 antibody at (A) 1 and (B) 2 µg/ml. 50 μg Log in to see 6至8个工作日
$390.50
详细

更多抗Pleckstrin Homology Domain Containing, Family O Member 1的相互作用对抗体

Human Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations.

  2. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.

  3. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.

  4. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  5. High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.

  6. New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL (显示 RTEL1 抗体)) and targeting CKIP-1 may be a novel therapeutic target for NHL (显示 RTEL1 抗体).

  7. There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (显示 PAK1 抗体) for neoplastic prostate cells transformation.

  8. CKIP-1 interacts with CARMA1 (显示 CARD11 抗体) and has an inhibitory effect on PKCtheta (显示 PRKCQ 抗体);-CBM-NF-kappaB (显示 NFKB1 抗体) signaling.

  9. CKIP-1 controlled Smurf1 (显示 SMURF1 抗体) expression in colon cancer

  10. overexpression triggers classical monocyte activation and transactivation of the TNF (显示 TNF 抗体) promoter

Mouse (Murine) Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.

  2. PD increased CKIP-1 and Nrf2 (显示 NFE2L2 抗体) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (显示 ICAM1 抗体)

  3. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.

  4. The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 (显示 MAPK8 抗体) phosphorylation and further upregulating IRS-1 (显示 IRS1 抗体) phosphorylation and RI.

  5. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  6. Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1 (显示 ICAM1 抗体)) and fibronectin (显示 FN1 抗体) plus activation of Nrf2 (显示 NFE2L2 抗体)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.

  7. the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis

  8. CKIP-1 is a novel inhibitor of MSC (显示 MSC 抗体)-originated adipogenesis by enhancing HDAC1 (显示 HDAC1 抗体)-associated repression of C/EBPalpha (显示 CEBPA 抗体).

  9. CKIP-1 interacts with TRAF6 (显示 TRAF6 抗体), a ubiquitin ligase (显示 RNF123 抗体) required for K63-linked ubiquitination and plasma membrane recruitment of Akt (显示 AKT1 抗体), and terminates TRAF6 (显示 TRAF6 抗体)-mediated Akt (显示 AKT1 抗体) activation.

  10. Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.

Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) 抗原简介

蛋白简介

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).

Gene names and symbols associated with PLEKHO1

  • pleckstrin homology domain containing O1 (PLEKHO1) 抗体
  • pleckstrin homology domain containing, family O member 1 (Plekho1) 抗体
  • pleckstrin homology domain containing O1 (Plekho1) 抗体
  • pleckstrin homology domain containing, family O member 1a (plekho1a) 抗体
  • 2810052M02Rik 抗体
  • ckip-1 抗体
  • Ckip1 抗体
  • JZA-20 抗体
  • Jza2 抗体
  • OC120 抗体
  • plekho1 抗体
  • RGD1311487 抗体
  • si:dkey-200h23.2 抗体

Protein level used designations for PLEKHO1

2810052M02Rik , C-Jun-binding protein , CK2 interacting protein 1; HQ0024c protein , CK2-interacting protein 1 , JBP , OC120 , PH domain-containing family O member 1 , casein kinase 2-interacting protein 1 , osteoclast maturation-associated gene 120 protein , pleckstrin homology domain-containing family O member 1 , pleckstrin homology domain containing, family O member 1 , CK2 interacting protein 1 , Jun zipper-associated 2 , TNF intracellular domain-interacting protein , CK2-interacting protein-1 , PH domain-containing family O member 1-A , pleckstrin homology domain-containing family O member 1-A

GENE ID SPECIES
51177 Homo sapiens
426108 Gallus gallus
457268 Pan troglodytes
607927 Canis lupus familiaris
706145 Macaca mulatta
788251 Bos taurus
100152184 Sus scrofa
100347162 Oryctolagus cuniculus
100444299 Pongo abelii
67220 Mus musculus
310674 Rattus norvegicus
563283 Danio rerio
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