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The protein encoded by PLEKHM1 is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. 再加上，我们可以发PLEKHM1 蛋白 (4)和数多这个蛋白质的别的产品。
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identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome
Authors show that Pleckstrin (显示 PLEK 抗体) homology domain-containing protein family member 1 (PLEKHM1), a lysosomal adaptor, is targeted by Salmonella through direct interaction with SifA.
PLEKHM1 regulates autophagosome-lysosome fusion through homotypic fusion and protein sorting complex and LC3 (显示 MAP1LC3A 抗体)/GABARAP (显示 GABARAP 抗体) proteins.
Rubicon (显示 KIAA0226 抗体) and PLEKHM1 specifically and directly interact with Rab7 (显示 RAB7B 抗体) via their RH domain; this interaction is critical for their function; show Rubicon (显示 KIAA0226 抗体) but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 (显示 RAB7B 抗体) and PI3-kinase (显示 PIK3CA 抗体)
These data indicate that B2 is a novel, ubiquitously expressed protein with a putative adapter function. The protein has been named AP162.
PLEKHM1 is a novel gene implicated in the development of osteopetrosis (显示 CSF1 抗体), with a putative critical function in vesicular transport in the osteoclast.
heterozygous mutation (R714C) of the osteopetrosis (显示 CSF1 抗体) gene, pleckstrin (显示 PLEK 抗体) homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP (显示 ACP5 抗体) secretion in osteoclasts
TRAFD1 (显示 TRAFD1 抗体), in association with Plekhm1/Rab7 (显示 RAB7A 抗体)-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts
results indicate that LIS1 (显示 PAFAH1B1 抗体) is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1
The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene.
pleckstrin homology domain containing, family M (with RUN domain) member 1
, 162 kDa adapter protein
, PH domain-containing family M member 1
, pleckstrin homology domain-containing family M member 1