anti-Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) 抗体

The protein encoded by PLEKHM1 is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. 再加上,我们可以发PLEKHM1 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PLEKHM1 9842 Q9Y4G2
PLEKHM1 353047 Q7TSI1
PLEKHM1 303584 Q5PQS0
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antibodies-online.cn销售最多的anti-PLEKHM1 抗体

Showing 10 out of 48 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 EIA, WB Western blot analysis of PLEKHM1 Antibody (N-term) in K562 cell line lysates (35ug/lane). This demonstrates the PLEKHM1 antibody detected the PLEKHM1 protein (arrow). 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 WB PLEKHM1 Antibody (N-term) (ABIN656973) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the PLEKHM1 antibody detected the PLEKHM1 protein (arrow). 400 μL Log in to see 10至11个工作日
$335.50
详细
非结合性 EIA, IHC (p), WB   0.1 mg Log in to see Available
$474.10
详细
非结合性 IHC, ELISA, WB 100 μg Log in to see 7至9个工作日
$551.83
详细
小鼠 非结合性 ELISA Detection limit for recombinant GST tagged PLEKHM1 is approximately 1 ng/mL as a capture antibody. Detection limit for recombinant GST tagged PLEKHM1 is approximately 1ng/ml as a capture antibody. 100 μg Log in to see 8至11个工作日
$461.00
详细
非结合性 IF, IHC, ELISA, WB   100 μg Log in to see 15至19个工作日
$523.71
详细
小鼠 非结合性 ELISA Detection limit for recombinant GST tagged PLEKHM1 is approximately 1ng/ml as a capture antibody. 100 μg Log in to see 11至12个工作日
$440.00
详细
非结合性 ELISA, WB   200 μL Log in to see 11至16个工作日
$594.00
详细
HRP IHC (p), WB   100 μL Log in to see 14至21个工作日
$405.90
详细
Alexa Fluor 488 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细

通过反应活性、应用领域、克隆类型和共轭标记 PLEKHM1 抗体

特性 应用范围 宿主 克隆类型 标记
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更多抗PLEKHM1的相互作用对抗体

Human Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) interaction partners

  1. identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome

  2. Authors show that Pleckstrin (显示 PLEK 抗体) homology domain-containing protein family member 1 (PLEKHM1), a lysosomal adaptor, is targeted by Salmonella through direct interaction with SifA.

  3. PLEKHM1 regulates autophagosome-lysosome fusion through homotypic fusion and protein sorting complex and LC3 (显示 MAP1LC3A 抗体)/GABARAP (显示 GABARAP 抗体) proteins.

  4. Rubicon (显示 KIAA0226 抗体) and PLEKHM1 specifically and directly interact with Rab7 (显示 RAB7B 抗体) via their RH domain; this interaction is critical for their function; show Rubicon (显示 KIAA0226 抗体) but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 (显示 RAB7B 抗体) and PI3-kinase (显示 PIK3CA 抗体)

  5. These data indicate that B2 is a novel, ubiquitously expressed protein with a putative adapter function. The protein has been named AP162.

  6. PLEKHM1 is a novel gene implicated in the development of osteopetrosis (显示 CSF1 抗体), with a putative critical function in vesicular transport in the osteoclast.

  7. heterozygous mutation (R714C) of the osteopetrosis (显示 CSF1 抗体) gene, pleckstrin (显示 PLEK 抗体) homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP (显示 ACP5 抗体) secretion in osteoclasts

Mouse (Murine) Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) interaction partners

  1. TRAFD1 (显示 TRAFD1 抗体), in association with Plekhm1/Rab7 (显示 RAB7A 抗体)-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts

  2. identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome

  3. results indicate that LIS1 (显示 PAFAH1B1 抗体) is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1

PLEKHM1 抗原简介

蛋白简介

The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with PLEKHM1

  • pleckstrin homology and RUN domain containing M1 (PLEKHM1) 抗体
  • pleckstrin homology domain containing, family M (with RUN domain) member 1 (PLEKHM1) 抗体
  • pleckstrin homology domain containing, family M (with RUN domain) member 1 (Plekhm1) 抗体
  • pleckstrin homology and RUN domain containing M1 (Plekhm1) 抗体
  • AP162 抗体
  • B2 抗体
  • BC038943 抗体
  • D330036J23Rik 抗体
  • OPTB6 抗体

Protein level used designations for PLEKHM1

pleckstrin homology domain containing, family M (with RUN domain) member 1 , 162 kDa adapter protein , PH domain-containing family M member 1 , pleckstrin homology domain-containing family M member 1

GENE ID SPECIES
454754 Pan troglodytes
490925 Canis lupus familiaris
9842 Homo sapiens
353047 Mus musculus
303584 Rattus norvegicus
100523462 Sus scrofa
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