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The protein encoded by PPRC1 is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). 再加上，我们可以发PPRC1 抗体 (31) 和 和数多这个蛋白质的别的产品。
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these results indicated an elevated basal metabolic rate and lipid metabolic alteration of male Pprc1(+/-) mice on high-fat diet, suggesting the significant role of Pprc1 in controlling mitochondrial gene expression and energy metabolic processes
Homozygous deficient PPRC1 mice failed to form egg cylinders and died after implantation but before embryonic day 6.5, whereas mice heterozygous for PPRC1 were viable, fertile and indistinguishable from their wild-type littermates.
PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress.
PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB (显示 NFKB1 ELISA试剂盒) activity
A general role for PRC in the adaptive response to cellular dysfunction.
PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle
overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma
PGC-1 (显示 PPARGC1A ELISA试剂盒) has a role in regulating gluconeogenic genes along with HNF-4alpha (显示 HNF4A ELISA试剂盒) and SREBP-1 (显示 SREBF1 ELISA试剂盒)
This review focuses on the biologic and physiologic functions of the PGC-1 (显示 PPARGC1A ELISA试剂盒) coactivators, with particular emphasis on striated (显示 NSDHL ELISA试剂盒) muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
Upregulation of PGC-1alpha (显示 PPARGC1A ELISA试剂盒) and PGC-1beta (显示 PPARGC1B ELISA试剂盒) in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on oxidative phosphorylation.
These results revealed that bile acid inhibits the promoter activity of PGC-1 (显示 PPARGC1A ELISA试剂盒) in an SHP (显示 LAMC1 ELISA试剂盒)-dependent manner.
Activation of the SIRT1 (显示 SIRT1 ELISA试剂盒)/PGC-1 (显示 PPARGC1A ELISA试剂盒) pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review.
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.
, peroxisome proliferator-activated receptor gamma coactivator-related protein 1
, PGC-1 related co-activator
, peroxisome proliferative activated receptor, gamma, coactivator-related 1