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Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). 再加上，我们可以发PXDN 抗体 (20) 和 PXDN 蛋白 (9)和数多这个蛋白质的别的产品。
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PXDN might play a promoter role in the proliferation, invasion and migration of ovarian cancer (OC) cells through regulating the activation of PI3K (显示 PIK3CA ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒) pathway. Therefore, PXDN might be regarded as a potential target for OC therapy.
e showed that collagen IV (显示 COL4 ELISA试剂盒) crosslinks remain intact even under strongly hypoxic conditions. Our hypothesis is that during collagen IV (显示 COL4 ELISA试剂盒) network formation PXDN cooperates with a NOX/DUOX (显示 DUOX1 ELISA试剂盒)-independent H2O2 source that is functional also at very low ambient oxygen levels.
Data indicate that VPO1 plays a critical role in regulating eNOS (显示 NOS3 ELISA试剂盒) expression and activity by structural change and de-phosphorylation. VPO1 expression was up-regulated in Ang (显示 ANG ELISA试剂盒)-treated HUVECs. Knockdown of VPO1 was su ffi cient to attenuate the Ang (显示 ANG ELISA试剂盒) induced decrease in eNOS (显示 NOS3 ELISA试剂盒) expression and activity. Moreover, the e ff ect of VPO1 on eNOS (显示 NOS3 ELISA试剂盒) was mainly achieved by HOCl formation.
Results show that PXDN expression decreases with TGF-beta1 (显示 TGFB1 ELISA试剂盒) treatment in cervical carcinoma cell lines, and is regulated by the EMT (显示 ITK ELISA试剂盒) master transcription factor Snai1 (显示 SNAI1 ELISA试剂盒). This implicates PXDN in cancer development and processes that involve EMT (显示 ITK ELISA试剂盒).
Data suggest that VPO1 contributes to oxidation and retention of LDL in vessel walls, and formation foam cells, indicating VPO1 as a novel potential mediator of atherosclerosis.
VPO1 plays a critical role in asymmetric dimethylarginine production via H2O2-VPO1-hypochlorous acid pathways, which may contribute to endothelial dysfunction in hypertension.
PC processing of Pxdn is a key regulatory step that contributes to its function and, therefore, supports BM integrity and homeostasis.
PXDN expression is significantly upregulated in human masticatory mucosa during wound healing
Novel mutations in PXDN cause microphthalmia and anterior segment dysgenesis
Despite sequence homology at the active site and biophysical properties similar to human peroxidases, the catalytic efficiency of bromide oxidation (kcat/KM(app (显示 APP ELISA试剂盒))) of full-length hsPxd01 is rather low but increased upon truncation.
Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1 (显示 COL4A1 ELISA试剂盒), GPBP (显示 COL4A3BP ELISA试剂盒), Lamc1 (显示 LAMC1 ELISA试剂盒), peroxidasin) during uterine reprogramming.
Cdkn1b (显示 CDKN1B ELISA试剂盒) exert its effects via the inhibition of proliferation and is mediated by miR (显示 MLXIP ELISA试剂盒)-24 and targeted by the transcription factors FOXO4 (显示 FOXO4 ELISA试剂盒) and AP4 (显示 REPIN1 ELISA试剂盒) in the peroxidasin (Pxdn) mutation-induced eye disorders, such as glaucoma.
Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999
melanoma-associated antigen MG50
, p53-responsive gene 2 protein
, peroxidasin homolog
, vascular peroxidase 1