Use your antibodies-online credentials, if available.
Members of the perilipin family, such as PLIN5, coat intracellular lipid storage droplets and protect them from lipolytic degradation (Dalen et al., 2007 [PubMed 17234449]).[supplied by OMIM, Feb 2010].. 再加上，我们可以发Perilipin 5 抗体 (41) 和 Perilipin 5 蛋白 (5)和数多这个蛋白质的别的产品。
Showing 1 out of 5 products:
C/EBPalpha (显示 CEBPA ELISA试剂盒) is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPalpha (显示 CEBPA ELISA试剂盒) expression.
The data highlight a key role of PLIN5 in lipid droplets function, first by finely adjusting lipid droplets fatty acids supply to mitochondrial oxidation, and second acting as a protective factor against lipotoxicity in skeletal muscle.
Notch1 expression is reduced and glu (显示 G6PC ELISA试剂盒)cose-6-phosphatase and (显示 G6PC ELISA试剂盒) perilipin-5 (G6PC/PLIN5) are upr (显示 NOTCH1 ELISA试剂盒)egulated in liver biopsies from nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) patients.
High oxygen consumption in middle-aged men was reflected in higher perilipin 5 expression in skeletal muscle.
PLIN5 was significantly colocated with ATGL (显示 PNPLA2 ELISA试剂盒), mitochondria and CGI-58 (显示 ABHD5 ELISA试剂盒), indicating a close association between the key lipolytic effectors in resting skeletal muscle.
Perilipin 5 as a lipid droplet protein adapted to mitochondrial energy utilization
Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 (显示 PLIN2 ELISA试剂盒) and 5
PLIN5 likely plays an important role in intramyocellular lipid accumulation and oxidation, both of which increase with endurance training in human skeletal muscle.
The lipid droplet coat protein (显示 GOLPH3 ELISA试剂盒) perilipin 5 also localizes to muscle mitochondria.
Perilipin 5 is the most recently established family member, highly expressed in oxidative tissues and could play an important role in regulating LD TAG hydrolysis in oxidative mammalian tissues. [Review]
interaction of ATGL (显示 PNPLA2 ELISA试剂盒) with CGI-58 (显示 ABHD5 ELISA试剂盒) increased lipolysis, whereas interaction of ATGL (显示 PNPLA2 ELISA试剂盒) with perilipin 5 decreased lipolysis.
Plin5, a new regulator of myocardial lipid metabolism, decreases free fatty acid peroxidation by inhibiting the lipolysis of intracellular lipid droplets, thus providing cardioprotection against I/R injury and shedding new light on therapeutic solutions for I/R diseases.
During catecholamine-stimulated lipolysis, Perilipin 5 is phosphorylated by protein kinase A and forms transcriptional complexes with PGC-1alpha (显示 PPARGC1A ELISA试剂盒) and SIRT1 (显示 SIRT1 ELISA试剂盒) in the nucleus. Perilipin 5 promotes PGC-1alpha (显示 PPARGC1A ELISA试剂盒) co-activator function by disinhibiting SIRT1 (显示 SIRT1 ELISA试剂盒) deacetylase activity.
Changes in lipid metabolism resulting from PLIN5 deletion reduce ER stress in muscle, decrease FGF21 (显示 FGF21 ELISA试剂盒) production by muscle and liver, and impair glycemic control.
The results indicated that atorvastatin promoted lipolysis and reduced TG accumulation in the liver by increasing PKA-mediated phosphorylation of Plin5. This new mechanism of lipid-lowering effects of atorvastatin might provide a new strategy for NAFLD (显示 TSC2 ELISA试剂盒) treatment.
mitochondria isolated from hearts deficient in Plin5, have specific functional defects
Plin5 deficiency alters cardiac lipid metabolism and associates with reduced survival following myocardial ischemia.
Data show that glucose-6-phosphatase (显示 G6PC ELISA试剂盒) and perilipin-5 (G6PC (显示 G6PC ELISA试剂盒)/PLIN5) are upregulated in notch1 (显示 NOTCH1 ELISA试剂盒) knockout (KO) mice.
PLIN5 is dispensable for normal substrate metabolism during exercise and is not required to promote mitochondrial biogenesis or enhance the cellular adaptations to endurance exercise training.
High fat diet-induced liver fibrosis is accompanied by an approximate 75% reduction in Plin5 in hepatic stellate cells (HSC), and spontaneous activation of primary HSC produces temporally coincident loss of Plin5 expression and lipid droplet depletion.
Members of the perilipin family, such as PLIN5, coat intracellular lipid storage droplets and protect them from lipolytic degradation (Dalen et al., 2007
lipid storage droplet protein 5
, perilipin 5
, lipid droplet associated protein
, lipid droplet-associated protein PAT-1
, myocardial LD protein