anti-PTEN Induced Putative Kinase 1 (PINK1) 抗体

PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. 再加上,我们可以发PINK1 蛋白 (13)PINK1 试剂盒 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PINK1 65018 Q9BXM7
PINK1 68943 Q99MQ3
PINK1 298575  
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antibodies-online.cn销售最多的anti-PINK1 抗体

Showing 10 out of 259 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ELISA, ICC, IF, IHC, IHC (p), IP, WB Immunocytochemistry/Immunofluorescence: PINK1 Antibody [BC100-494] - Immunocytochemistry of PINK1 antibody (BC100-494 Lot G). HeLa cells were treated with valinomycin (1 uM for 24h) prior to being fixed in 10% buffered formalin for 10 min and permeabilized in 0.1% Triton X-100 in PBS for 10 min. Cells were incubated with BC100-494 at 20 ug/ml for 1h at room temperature, washed 3x in PBS and incubated with Alexa-Fluor488 anti-rabbit secondary antibody. PINK1 (Green) was detected at the mitochondria. Tubulin (Red) was detected using an anti-tubulin antibody with an anti-mouse DyLight 550 secondary antibody. DNA (Blue) was counterstained with DAPI. Note: mitochondria staining might not be easily observed without treatment with valinomycin or CCCP. Western Blot: PINK1 Antibody [BC100-494] - Whole cell protein from HeLa cells treated without or with valinomycin (1 uM for 24h) as indicated were separated by SDS-PAGE on a 7.5% polyacrylamide gel. Protein was transferred to PVDF membrane and probed with 1.0 ug/ml BC100-494 in 1% BSA and detected with an HRP-conjugated anti-rabbit secondary antibody using chemiluminescence. PINK1 was detected at approximately 60 kDa in the treated sample(arrowhead). 0.1 mL Log in to see 7至9个工作日
$514.63
详细
大鼠 山羊 非结合性 ELISA, WB ABIN334460 (1µg/ml) staining of Rat Testis lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$429.62
详细
非结合性 IHC (p), WB Western blot analysis of anti-PARK6 Pab (ABIN390369) in mouse kidney tissue lysate. PARK6 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10至11个工作日
$335.50
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非结合性 WB 0.1 mL Log in to see 7至9个工作日
$415.44
详细
小鼠 非结合性 ICC, IF, IHC, IHC (p), WB Western Blot: PINK1 Antibody (8E10.1D6) [NBP2-36488] - Whole cell protein from HeLa cells treated with or without valinomycin (1 uM for 24h) as indicated was separated by SDS-PAGE on a 7.5% polyacrylamide gel. Protein was transferred to PVDF membrane and probed with 2 ug/ml anti-PINK1 in 1% BSA and detected with an HRP-conjugated anti-mouse secondary antibody using chemiluminescence. PINK1 is seen to be upregulated at approximately 60 kDa (arrowhead) with treament. Western Blot: PINK1 Antibody (8E10.1D6) [NBP2-36488] - WB analysis of (A) 13kDa Partial Recombinant Human PINK-1 protein and (B) Human Liver lysate using PINK1 antibody clone 8E10.1D6 at 3ug/ml concentration. 0.1 mg Log in to see 7至9个工作日
$444.19
详细
非结合性 WB 100 μg Log in to see 2至3个工作日
$255.00
详细
Cow 非结合性 IHC, WB 100 μL Log in to see 2至3个工作日
$319.00
详细
小鼠 非结合性 IHC (p), WB Western blot analysis of PINK (arrow) using mouse monoclonal PINK antibody (ABIN387803). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PINK gene (Lane 2) (Origene Technologies) Fluorescent image of PC12 cells stained with Pink1(115-213) Antibody (ABIN2843897). ABIN2843897 was diluted at 1:25 dilution. An Alexa Fluor® 488-conjugated goat anti-mouse lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red). 400 μL Log in to see 10至11个工作日
$335.50
详细
非结合性 SimWes, WB Western blot of C-terminally V5His-tagged human Pink1 or N-terminally myc-tagged human Pink1 expressed in HEK293T cells.  ABIN152067 detects transfected Pink1 protein. Simple Western: PINK1 Antibody [ABIN152067] - Simple Western lane view shows a specific band for PINK1 in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mg Log in to see 7至9个工作日
$345.00
详细
非结合性 ICC, IHC, WB Figure. Western Blot; Lane1: Human Serum; Lane2: Mouse Heart Tissue. 100 μg Log in to see 13至16个工作日
$384.00
详细

引用最多的anti-PINK1 抗体

  1. Human Polyclonal PINK1 Primary Antibody for ELISA, ICC - ABIN249446 : Weihofen, Ostaszewski, Minami, Selkoe: Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. in Human molecular genetics 2008 (PubMed)
    Show all 106 Pubmed References

  2. Human Polyclonal PINK1 Primary Antibody for WB - ABIN151937 : Meijer, Karimi-Busheri, Huang, Weinfeld, Young: Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal PINK1 Primary Antibody for WB - ABIN1882117 : Rogaeva, Johnson, Lang, Gulick, Gwinn-Hardy, Kawarai, Sato, Morgan, Werner, Nussbaum, Petit, Okun, McInerney, Mandel, Groen, Fernandez, Postuma, Foote: Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. in Archives of neurology 2004 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal PINK1 Primary Antibody for SimWes, WB - ABIN152067 : Xiong, Wang, Chen, Choo, Ma, Tang, Xia, Jiang, Ronai, Zhuang, Zhang: Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. in The Journal of clinical investigation 2009 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal PINK1 Primary Antibody for ELISA, WB - ABIN566297 : Liu, Ye, Miller, Yuan, Zhang, Tian, Nie, Imae, Arai, Li, Cheng, Shi: Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy. in Molecular and cellular biology 2012 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal PINK1 Primary Antibody for IHC, WB - ABIN2115285 : Zhou, Huang, Shao, May, Prou, Perier, Dauer, Schon, Przedborski: The kinase domain of mitochondrial PINK1 faces the cytoplasm. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal PINK1 Primary Antibody for IHC (p), WB - ABIN387802 : Dagda, Gusdon, Pien, Strack, Green, Li, Van Houten, Cherra, Chu: Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease. in Cell death and differentiation 2012 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal PINK1 Primary Antibody for IHC (p), WB - ABIN390369 : Zhang, Gu, Chen, Ni, Hung, Wang, Zhang, Feng, Ji: High expression of PINK1 promotes proliferation and chemoresistance of NSCLC. in Oncology reports 2017 (PubMed)
    Show all 2 Pubmed References

  9. Human Polyclonal PINK1 Primary Antibody for WB - ABIN652208 : Berthier, Jiménez-Sáinz, Pulido: PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)

  10. Human Monoclonal PINK1 Primary Antibody for ICC, IF - ABIN4345677 : Ko, Park, Park, Koh: PPAR-γ activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction. in Toxicology letters 2016 (PubMed)

更多抗PINK1的相互作用对抗体

Fruit Fly (Drosophila melanogaster) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. This study found learning and memory abnormalities in PINK1 mutant genotypes in Drosophila.

  2. Drosophila CHIP protects against mitochondrial dysfunction by acting downstream of Pink1 in parallel with Parkin (显示 PARK2 抗体)

  3. Maintenance of tissue homeostasis upon reduction of Pink1 or Parkin (显示 PARK2 抗体) appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.

  4. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin (显示 PARK2 抗体) flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  5. autophosphorylation of PINK1 is essential for the mitochondrial translocation of Parkin (显示 PARK2 抗体) and for subsequent phosphorylation and activation of Parkin (显示 PARK2 抗体).

  6. A pink1 genomic knock-in allele was generated to monitor the dynamic expression pattern of PINK1. The spatiotemporal expression pattern of PINK1 correlates with the cell-type specific mitochondrial clearance or persistence. PINK1 and PARKIN (显示 PARK2 抗体) function epistatically to mediate timely specific mitophagy during Drosophila midgut metamorphosis.

  7. Our data indicate that PINK1 and Parkin (显示 PARK2 抗体) play an important role in FUS (显示 FUS 抗体)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (显示 FUS 抗体) proteinopathy and PINK1/Parkin (显示 PARK2 抗体) genes, providing new insights into the pathogenesis of FUS (显示 FUS 抗体) proteinopathy.

  8. we show that overexpression of Drosophila Clu (显示 CLU 抗体) complements PINK1, but not parkin (显示 PARK2 抗体), mutant muscles. Thus, Clu (显示 CLU 抗体) is essential for mitochondrial homeostasis and functions in concert with Parkin (显示 PARK2 抗体) and VCP (显示 vcp 抗体) for Marf (显示 MFN2 抗体) degradation to promote damaged mitochondrial clearance.

  9. In addition, a PINK1 mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1 (显示 RAP1GDS1 抗体), played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF (显示 SLC2A4RG 抗体) member.

  10. Buffy has a role enhancing the loss of parkin (显示 PARK2 抗体) and suppressing the loss of Pink1 phenotypes in Drosophila

Zebrafish PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Pink1-depleted zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons.

  2. Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway.

  3. Distinct groups of dopaminergic neurons are sensitive to targeted loss of Pink1 factor in a morphant fish model of toxin-induced Parkinson's disease.

  4. Morpholino-mediated loss of pink1 function in zebrafish profoundly affects the development of dopaminergic neurons in the ventral diencephalon and affects behaviour of the zebrafish larvae, namely their response to tactile stimuli and locomotor behavior.

Human PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Results describe a novel pathogenic mechanism in recessive Parkinson's disease, where PINK1 deficiency may increase neuron death via exacerbation of inflammatory stimuli-induced nitric oxide production and abnormal innate immune responses in glia cells.

  2. The results demonstrate that Nix (显示 BNIP3L 抗体) can serve as an alternative mediator of mitophagy to maintain mitochondrial turnover, identifying Nix (显示 BNIP3L 抗体) as a promising target for neuroprotective treatment in PINK1/Parkin (显示 PARK2 抗体)-related Parkinson's disease.

  3. Studies indicate a functional PTEN-induced putative kinase 1)(PINK1)/E3 ubiquitin protein ligase (parkin (显示 PARK2 抗体)) mitophagy pathway in neurons [Review].

  4. PINK1 detection could help stratify patients who may have poor response to chemotherapy and guide the individual treatment.

  5. A mitochondrial protein PINK1 acts as a mitochondrial gatekeeper able to sense the presence of healthy or damaged mitochondria. (Review)

  6. mitochondrial dysfunction activates the PINK1/Parkin (显示 PARK2 抗体) signaling and mitophagy in renal tubular epithelial cells under albumin (显示 ALB 抗体) overload condition.

  7. High Pink1 Expression is Associated with Cancer Progression and Chemo-Resistance in Esophageal Squamous Cell Carcinoma.

  8. Hsp70participated in PINK1-mediated mitophagy by stabilizing PINK1.

  9. This study showed that the heterozygous Pink1 mutation carriers show subtle motor abnormalities when a detailed, specialized motor examination is applied and compared to mutation-negative matched control subjects.

  10. These findings provide evidence for a novel mechanism underlying the protective effects of PINK1 against alpha-syn-induced neurodegeneration and highlight a novel therapeutic target for Parkinson's disease treatment.

Mouse (Murine) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. The data supports an indispensable role for Mule in cardiac homeostasis through the regulation of mitochondrial function via maintenance of Pgc-1alpha and Pink1 expression and persistent negative regulation of c-Myc (显示 MYC 抗体).

  2. these data suggest that alleviation of the sustained mitochondrial dysfunction and oxidative stress through co-modulation of NRF2 (显示 NFE2L2 抗体) and PINK1 may be in charge of restoration of the cognitive impairments in a mouse model of high-LET carbon ion irradiation

  3. This paper's findings delineate a mechanism by which PINK1 regulates mitochondrial Ca(2 (显示 CA2 抗体)+) level through LETM1 (显示 LETM1 抗体) and suggest a model by which PINK1 loss leads to deficient phosphorylation of LETM1 (显示 LETM1 抗体) and impaired mitochondrial Ca(2 (显示 CA2 抗体)+) transport.

  4. PINK1 and PARK2 (显示 PARK2 抗体) suppress pancreatic tumorigenesis through control of mitochondrial iron-mediated immunometabolism

  5. This study demonstrated that in the Pink1-/- mouse showed disorder of vocalization and sensorimotor function.

  6. reveal a direct molecular link between nitrosative stress, S-nitrosylated PINK1 formation, and mitophagic dysfunction that contributes to the pathogenesis of Parkinson's disease

  7. In mitochondria from Pink1(-/-) mice, there was a decrease in free chloride and in free supercomplexes in cultured neurons.

  8. These findings provide evidence for a novel mechanism underlying the protective effects of PINK1 against alpha-syn-induced neurodegeneration and highlight a novel therapeutic target for Parkinson's disease treatment.

  9. The results of this study identify PINK1 deficiency as an early modulator of innate immunity in neurons, which precedes late stages of neuroinflammation during alpha-synuclein spreading.

  10. The expression of PINK1 and Parkin (显示 PARK2 抗体) were elevated in white adipose tissue in obese mice.

PINK1 抗原简介

蛋白简介

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Gene names and symbols associated with PINK1

  • PTEN-induced putative kinase 1 (Pink1) 抗体
  • PTEN induced putative kinase 1 (PINK1) 抗体
  • PTEN induced putative kinase 1 (pink1) 抗体
  • PTEN induced putative kinase 1 (Pink1) 抗体
  • 1190006F07Rik 抗体
  • AU042772 抗体
  • AW557854 抗体
  • BEST:GH23468 抗体
  • BRPK 抗体
  • CG4523 抗体
  • Dmel\\CG4523 抗体
  • dPink1 抗体
  • mFLJ00387 抗体
  • PARK6 抗体
  • PINK 抗体
  • pink1 抗体
  • wu:fc39e12 抗体
  • zgc:101729 抗体

Protein level used designations for PINK1

CG4523-PA , CG4523-PB , CG4523-PC , CG4523-PD , CG4523-PE , CG4523-PF , CG4523-PG , CG4523-PH , PTEN induced putative kinase 1 , PTEN-Induced kinase 1 , Pink1-PA , Pink1-PB , Pink1-PC , Pink1-PD , Pink1-PE , Pink1-PF , Pink1-PG , Pink1-PH , PTEN-induced putative kinase 1 , serine/threonine-protein kinase PINK1, mitochondrial , serine/threonine-protein kinase PINK1, mitochondrial-like , PTEN-induced putative kinase protein 1 , protein kinase BRPK

GENE ID SPECIES
31607 Drosophila melanogaster
425370 Gallus gallus
494085 Danio rerio
510683 Bos taurus
706037 Macaca mulatta
749028 Pan troglodytes
100027082 Monodelphis domestica
100412264 Callithrix jacchus
100443445 Pongo abelii
100465867 Ailuropoda melanoleuca
65018 Homo sapiens
68943 Mus musculus
298575 Rattus norvegicus
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