anti-PRP8 Pre-MRNA Processing Factor 8 Homolog (S. Cerevisiae) (PRPF8) 抗体

Pre-mRNA splicing occurs in 2 sequential transesterification steps. 再加上,我们可以发和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PRPF8 287530  
PRPF8 10594 Q6P2Q9
PRPF8 192159 Q99PV0
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Showing 10 out of 35 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-PRPF8 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Jurkat cell lysate PRPF8 is supported by BioGPS gene expression data to be expressed in Jurkat WB Suggested Anti-PRPF8 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: Jurkat cell lysate <br /> PRPF8 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 IP, WB Immunohistochemistry of paraffin-embedded rat brain using PRPF8 antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 16 Days
$476.15
详细
非结合性 IHC, WB Western blot analysis of extracts of various cell lines, using PRPF8 antibody (ABIN5973594) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human esophagus using PRPF8 antibody (ABIN5973594) at dilution of 1/100 (40x lens). 100 μL Log in to see 11至16个工作日
$426.40
详细
小鸡 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: PRPF8 Antibody [NBP2-22272] - FFPE serial sections of human colon carcinoma. Antibody: Affinity purified rabbit anti-PRPF8 (Cat. No. NBP2-22272, left panel, NBP2-22273, middle panel and Cat. No. NBP2-22274, right panel) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB Western Blot: PRPF8 Antibody [NBP2-22272] - Whole cell lysate from 293T (15 and 50 ug), HeLa (50 ug), Jurkat (50 ug), and mouse NIH3T3 (50 ug) cells. NBP2-22272 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. 100 μL Log in to see 7至9个工作日
$556.31
详细
小鼠 非结合性 DB, ICC, FACS, WB   50 μg Log in to see 7至9个工作日
$493.17
详细
小鼠 非结合性 DB, ICC, FACS, WB HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-PRPF8 antibody (shaded) or isotype control (unshaded) followed by Alexa Fluor 488 conjugated goat anti-mouse IgG. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-PRPF8 antibody. 50 μg Log in to see 6至8个工作日
$285.71
详细
非结合性 IHC, WB Western blot analysis of extracts of various cell lines, using PRPF8 antibody. Immunohistochemistry of paraffin-embedded human esophagus using PRPF8 antibody. 100 μL Log in to see 13至14个工作日
$411.13
详细
非结合性 WB PRPF8 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2至3个工作日
$473.93
详细
非结合性 ICC, IF, IHC, IHC (p), IP, WB Immunoprecipitation: PRPF8 Antibody [NBP2-22273] - Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-PRPF8 antibody NBP2-22273 used for IP at 6 ug/mg lysate. PRPF8 was also immunoprecipitated by rabbit anti-PRPF8 antibodies NBP2-22272 and NBP2-22274 For blotting immunoprecipitated PRPF8, NBP2-22273 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds. Western Blot: PRPF8 Antibody [NBP2-22273] - Whole cell lysate from 293T (15 and 50 ug), HeLa (50 ug), Jurkat (50 ug), and mouse NIH3T3 (50 ug) cells. NBP2-22273 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. 100 μL Log in to see 7至9个工作日
$556.31
详细

通过反应活性、应用领域、克隆类型和共轭标记 PRPF8 抗体

特性 应用范围 宿主 克隆类型 标记
Rat (Rattus)
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Human , ,
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Mouse (Murine)
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更多抗PRPF8的相互作用对抗体

Zebrafish PRP8 Pre-MRNA Processing Factor 8 Homolog (S. Cerevisiae) (PRPF8) interaction partners

  1. Within early haematopoiesis, myeloid differentiation is impaired, suggesting Prpf8 is required for haematopoietic development.

Human PRP8 Pre-MRNA Processing Factor 8 Homolog (S. Cerevisiae) (PRPF8) interaction partners

  1. Multiple genes contributing to the retinal dystrophy (显示 MERTK 抗体) genotypes within a family were discovered using retinal gene-targeted next-generation sequencing. Families with noted examples of phenotypic variation or apparent non-penetrant individuals may offer a clue to suspect complex inheritance.

  2. Frame-shift mutations and nonconservative amino acid changes in PRPF8 typically cause severe clinical phenotypes. The conservative missense variant p.PRPF8-Arg2310Lys that is not altering the global charge of the C-terminal tail, and variants located at the basis of the C-terminal tail show milder clinical phenotypes, in accordance with functional data on PRPF8/SNRNP200 (显示 SNRNP200 抗体) interactions in yeast.

  3. We show that PRP31 (显示 PRPF31 抗体), a component of U4 snRNP (显示 LSM2 抗体), is modified with K63-linked ubiquitin chains by the PRP19 (显示 PRPF19 抗体) complex and deubiquitinated by USP15 (显示 USP15 抗体) and its substrate targeting factor SART3 (显示 SART3 抗体). USP15SART3 makes a complex with USP4 (显示 USP4 抗体) and this ternary complex serves as a platform to deubiquitinate PRP31 (显示 PRPF31 抗体) and PRP3 (显示 CLCA4 抗体)

  4. HSP90 (显示 HSP90 抗体)/R2TP chaperone system promotes the assembly of a key module of U5 snRNP (显示 LSM2 抗体) while assuring the quality control of PRPF8. The proteomics data further reveal new interactions between R2TP and the tuberous sclerosis complex, pointing to a potential link between growth signals and the assembly of key cellular machines.

  5. influenza A virus upregulates cellular PRPF8 gene expression through viral NS1 protein and influenza virus polymerase basic protein 1 to increase virus production.

  6. Our findings exemplify the regulatory potential of changes in the core spliceosome machinery, which may be relevant to slow-onset human genetic diseases linked to PRPF8 deficiency

  7. Most importantly between Prp8 and nucleotides at the exon-intron junction.

  8. A mutation in a splicing factor (显示 SLU7 抗体) PRPF8 that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing.

  9. Data suggest Enterovirus 3DPol (RNA-dependent RNA polymerase) enters nucleus via nuclear localization signal, targets pre-mRNA processing factor 8 (Prp8) to block pre-mRNA splicing/mRNA synthesis, and shuts off cellular transcription/translation.

  10. In the cytoplasm, Prp8 forms a precursor complex with U5 snRNA

Mouse (Murine) PRP8 Pre-MRNA Processing Factor 8 Homolog (S. Cerevisiae) (PRPF8) interaction partners

  1. The mouse retinal pigment epithelium (RPE (显示 RPE 抗体))is the primary cell affected by mutations in the RNA splicing factors (PRPF3 (显示 PRPF3 抗体), PRPF8, and PRPF31 (显示 PRPF31 抗体)), and these changes occur at an early age.

  2. found that PRP31 (显示 PRPF31 抗体) and PRPC8 as well as snRNAs are highly expressed in retinal cells

  3. The finding of similar degenerative changes in RPE (显示 RPE 抗体) cells of all three mouse models suggests that the retinal pigment epithelium may be the primary cell type affected in the RNA splicing factor (显示 SLU7 抗体) forms of retinitis pigmentosa.

PRPF8 抗原简介

蛋白简介

Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.

Gene names and symbols associated with PRPF8

  • pre-mRNA processing factor 8 (Prpf8) 抗体
  • pre-mRNA processing factor 8 (prpf8) 抗体
  • pre-mRNA processing factor 8 S homeolog (prpf8.S) 抗体
  • pre-mRNA processing factor 8 (PRPF8) 抗体
  • AU019467 抗体
  • D11Bwg0410e 抗体
  • DBF3/PRP8 抗体
  • HPRP8 抗体
  • id:ibd1257 抗体
  • ik:tdsubc_2a9 抗体
  • im:7141966 抗体
  • prp-8 抗体
  • Prp8 抗体
  • PRPC8 抗体
  • RP13 抗体
  • Sfprp8l 抗体
  • SNRNP220 抗体
  • tdsubc_2a9 抗体
  • wu:fb37c02 抗体
  • wu:fb73e06 抗体
  • xx:tdsubc_2a9 抗体
  • zgc:56504 抗体

Protein level used designations for PRPF8

PRP8 pre-mRNA processing factor 8 homolog , pre-mRNA-processing-splicing factor 8 , 220 kDa U5 snRNP-specific protein , PRP8 homolog , U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p , apoptosis-regulated protein 1 , apoptosis-regulated protein 2 , p220 , precursor mRNA processing protein , splicing factor Prp8

GENE ID SPECIES
287530 Rattus norvegicus
393951 Danio rerio
379945 Xenopus laevis
417559 Gallus gallus
480651 Canis lupus familiaris
507371 Bos taurus
10594 Homo sapiens
192159 Mus musculus
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