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This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. 再加上，我们可以发PRDM2 抗体 (72) 和 PRDM2 蛋白 (6)和数多这个蛋白质的别的产品。
Promoter region methylation of RIZ1 may play an important role in the epigenetic silencing of RIZ1 expression in pituitary adenomas, which may translate into important diagnostic and therapeutic applications
RIZ1 expression is negatively correlated with glioma differentiation and can serve as a predictor of glioma prognosis and thus could be a potential therapeutic target for patients with gliomas.
Loss of RIZ1 expression due to methylation is associated with Renal Cell Carcinoma.
PRDM2 downregulation may play a role in dopamine-agonist resistance and tumor recurrence in prolactinomas.
Results suggest that high expression of SMYD3 (显示 SMYD3 ELISA试剂盒) is related to the occurrence of esophageal squamous cell carcinoma. Also, its suppression promoted the expression of RIZ1 suggesting a signal transduction pathway between SMYD3 (显示 SMYD3 ELISA试剂盒) and RIZ1.
PRDM2, PRDM5 (显示 PRDM5 ELISA试剂盒), PRDM16 (显示 PRDM16 ELISA试剂盒) promoters are methylated and their expression is suppressed in lung cancer cells.
The development and progression of esophageal squamous cell carcinoma are related to the inactivation of RIZ1.
RIZ1 expression is significantly downregulated as the formation of meningiomas progressed, and suggest that RIZ1 may represent a promising candidate tumor suppressor gene that contributes to malignant meningiomas.
Reduction of RIZ1 expression aggravates the progression of liver fluke-related cholangiocarcinoma
Aberrant methylation and decreased expression of the RIZ1 gene are frequent in adult acute lymphoblastic leukemia of T-cell phenotype
RIZ1 is an important regulator of both Akt3 (显示 AKT3 ELISA试剂盒) transcription and AKT (显示 AKT1 ELISA试剂盒) phosphorylation and suggest a role for RIZ1 in HF-induced obesity and the AKT (显示 AKT1 ELISA试剂盒) pathway
RIZ1 might participate osteoclast formation through the regulation of NFATc1 (显示 NFATC1 ELISA试剂盒) expression.
Data suggest that the histone methyltransferase RIZ1 is required for estrogen response in female reproductive tissues and that estrogen-bound estrogen receptors may turn a transcriptional repressor into a coactivator.
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
PR domain containing 2, with ZNF domain
, retinoblastoma protein-binding zinc finger protein-like
, PR domain zinc finger protein 2-like
, GATA-3 binding protein G3B
, GATA-3-binding protein G3B
, MTE-binding protein
, PR domain zinc finger protein 2
, PR domain-containing protein 2
, lysine N-methyltransferase 8
, retinoblastoma protein-binding zinc finger protein
, retinoblastoma protein-interacting zinc finger protein
, zinc finger protein RIZ
, zinc-finger DNA-binding protein
, retinoblastoma interacting zinc finger protein