PDZ and LIM Domain 2 (Mystique) 蛋白 (PDLIM2)

PDLIM2 encodes a member of the ALP subfamily of PDZ-LIM domain proteins.

列出全部蛋白 基因 基因ID UniProt
小鼠 PDLIM2 PDLIM2 213019 Q8R1G6
大鼠 PDLIM2 PDLIM2 290354 Q6AYD6
 PDLIM2 PDLIM2 64236 Q96JY6
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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更多PDZ and LIM Domain 2 (Mystique) (PDLIM2)互动伙伴

Mouse (Murine) PDZ and LIM Domain 2 (Mystique) (PDLIM2) interaction partners

  1. Klotho (显示 KL 蛋白) can modulate inflammation via PDLIM2/NF-kappaB (显示 NFKB1 蛋白) p65 (显示 NFkBP65 蛋白) pathway in cyclosporine A-induced nephropathy.

  2. Deficiency in PDLIM2 resulted in the accumulation of STAT3 (显示 STAT3 蛋白) in the nucleus, enhanced the extent of TH17 cell differentiation, and exacerbated granuloma formation.

  3. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.

  4. PDLIM2 expression was sufficient to suppress in vitro anchorage-independent growth and in vivo tumor formation of colon cancer. PDLIM2 repression involves promoter methylation.

  5. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells

  6. SLIM is a novel ubiquitin E3 ligase whose targets include STAT (显示 STAT1 蛋白) proteins.

  7. PDLIM2 deficiency resulted in larger amounts of nuclear p65 (显示 NFkBP65 蛋白), defective p65 (显示 NFkBP65 蛋白) ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli

  8. Stat-interacting LIM protein as the critical Stat (显示 STAT1 蛋白) ubiquitin E3 ligase involved in osteopontin (显示 SPP1 蛋白) regulation of Stat1 (显示 STAT1 蛋白).

  9. Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB (显示 NFKB1 蛋白) transcription reporter activity, and increased LPS (显示 TLR4 蛋白)-induced TNF-alpha (显示 TNF 蛋白) production.

Human PDZ and LIM Domain 2 (Mystique) (PDLIM2) interaction partners

  1. Data indicate that OR3A4 upregulation contributes to metastasis and tumorigenesis in gastric cancer by regulating the activation of PDLIM2, MACC1 (显示 MACC1 蛋白), NTN4, and GNB2L1 (显示 GNB2L1 蛋白).

  2. We conclude that inactivation of PDLIM2 is a recurrent finding in cHL (显示 CHRDL1 蛋白) and ALCL, promotes activation of inflammatory signaling pathways and thereby contributes to their pathogenesis

  3. Data show that shRNA mediated knockdown of PDZ and LIM domain protein 2 (PDLIM2) in both primary meningioma and schwannoma leads to significant reductions in cellular proliferation.

  4. PDLIM2 is epigenetically repressed in ovarian cancer development and inhibition of PDLIM2 promoted ovarian cancer growth both in vivo and in vitro via NOS2-derived nitric oxide signaling, leading to recruitment of M2 type macrophages.

  5. The suppression of PDLIM2 expression significantly reduced cell proliferation, cell growth and neoplasm invasiveness in prostate cancer cells.

  6. epigenetic repression of PDLIM2 can be reversed by 5-aza-2-deoxycytidine and vitamin D to suppress KSHV-associated cancer cell growth

  7. PDLIM2 expression is essential for feedback regulation of the beta1-integrin-RhoA (显示 RHOA 蛋白) signalling axis and integration of cellular microenvironment signals with gene expression to control the polarity of breast epithelial acini structures.

  8. PDLIM2 integrates cytoskeleton signaling with gene expression in epithelial differentiation by controlling the stability of key transcription factors and COP9 (显示 COPS8 蛋白) signalosome activity.

  9. PDLIM2 was a direct target gene of 1,25(OH)2D3

  10. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.

蛋白简介PDLIM2

蛋白简介

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PDLIM2

  • PDZ and LIM domain 2 (Pdlim2)
  • PDZ and LIM domain 2 (PDLIM2)
  • 4732462F18Rik 蛋白
  • MYSTIQUE 蛋白
  • SLIM 蛋白

Protein level used designations for PDLIM2

PDZ and LIM domain protein 2 , PDZ-LIM protein mystique , STAT-interacting LIM protein , mystique , alpha-actinins and filamin-interacting protein

GENE ID SPECIES
213019 Mus musculus
290354 Rattus norvegicus
64236 Homo sapiens
512907 Bos taurus
486123 Canis lupus familiaris
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