PDZ and LIM Domain 2 (Mystique) 蛋白 (PDLIM2)

PDLIM2 encodes a member of the ALP subfamily of PDZ-LIM domain proteins. 再加上,我们可以发PDLIM2 抗体 (58)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
PDLIM2 213019 Q8R1G6
大鼠 PDLIM2 PDLIM2 290354 Q6AYD6
PDLIM2 64236 Q96JY6
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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酵母菌 Cow His tag   1 mg Log in to see 60至71个工作日
$2,946.17
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酵母菌 Cynomolgus His tag   1 mg Log in to see 60至71个工作日
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PDLIM2 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human , ,
, ,

更多PDZ and LIM Domain 2 (Mystique) (PDLIM2)互动伙伴

Mouse (Murine) PDZ and LIM Domain 2 (Mystique) (PDLIM2) interaction partners

  1. Reducing NF-kappaB activation attenuates PDLIM2 deficiency-exacerbated inflammation and dyslipidemia in Palmitate -treated primary hepatocytes.

  2. Klotho can modulate inflammation via PDLIM2/NF-kappaB p65 pathway in cyclosporine A-induced nephropathy.

  3. Deficiency in PDLIM2 resulted in the accumulation of STAT3 in the nucleus, enhanced the extent of TH17 cell differentiation, and exacerbated granuloma formation.

  4. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.

  5. PDLIM2 expression was sufficient to suppress in vitro anchorage-independent growth and in vivo tumor formation of colon cancer. PDLIM2 repression involves promoter methylation.

  6. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells

  7. SLIM is a novel ubiquitin E3 ligase whose targets include STAT proteins.

  8. PDLIM2 deficiency resulted in larger amounts of nuclear p65, defective p65 ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli

  9. Stat-interacting LIM protein as the critical Stat ubiquitin E3 ligase involved in osteopontin regulation of Stat1.

  10. Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB transcription reporter activity, and increased LPS-induced TNF-alpha production.

Human PDZ and LIM Domain 2 (Mystique) (PDLIM2) interaction partners

  1. The results showed that (i) the use of SPR chip led to comparable data compared to on-column streptavidin beads, (ii) gravity flow and microflow in wash and elution steps provided better results than centrifugation, and (iii) type and concentration of detergent did not significantly affect the interactome data of cancer-associated PDLIM2.

  2. Data indicate that OR3A4 upregulation contributes to metastasis and tumorigenesis in gastric cancer by regulating the activation of PDLIM2, MACC1, NTN4, and GNB2L1.

  3. We conclude that inactivation of PDLIM2 is a recurrent finding in cHL and ALCL, promotes activation of inflammatory signaling pathways and thereby contributes to their pathogenesis

  4. Data show that shRNA mediated knockdown of PDZ and LIM domain protein 2 (PDLIM2) in both primary meningioma and schwannoma leads to significant reductions in cellular proliferation.

  5. PDLIM2 is epigenetically repressed in ovarian cancer development and inhibition of PDLIM2 promoted ovarian cancer growth both in vivo and in vitro via NOS2-derived nitric oxide signaling, leading to recruitment of M2 type macrophages.

  6. The suppression of PDLIM2 expression significantly reduced cell proliferation, cell growth and neoplasm invasiveness in prostate cancer cells.

  7. epigenetic repression of PDLIM2 can be reversed by 5-aza-2-deoxycytidine and vitamin D to suppress KSHV-associated cancer cell growth

  8. PDLIM2 expression is essential for feedback regulation of the beta1-integrin-RhoA signalling axis and integration of cellular microenvironment signals with gene expression to control the polarity of breast epithelial acini structures.

  9. PDLIM2 integrates cytoskeleton signaling with gene expression in epithelial differentiation by controlling the stability of key transcription factors and COP9 signalosome activity.

  10. PDLIM2 was a direct target gene of 1,25(OH)2D3

  11. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.

  12. PDLIM2 binds to Tax directly, which was mediated by a putative alpa-helix motif of PDLIM2 at amino acids 236-254.

  13. PDLIM2, an essential terminator of NF-kappaB activation, is repressed in both estrogen receptor-positive and estrogen receptor-negative breast cancer cells, suggesting one important mechanism for the constitutive activation of NF-kappaB.

  14. Data show that the PDLIM2 repression was independent of the viral regulatory protein Tax because neither short-term induction nor long-term stable expression of Tax could downregulate PDLIM2 expression.

  15. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells

  16. PDLIM2 deficiency resulted in larger amounts of nuclear p65, defective p65 ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli

  17. Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB transcription reporter activity, and increased LPS-induced TNF-alpha production.

蛋白简介PDLIM2

蛋白简介

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PDLIM2

  • PDZ and LIM domain 2 (Pdlim2)
  • PDZ and LIM domain 2 (PDLIM2)
  • 4732462F18Rik 蛋白
  • MYSTIQUE 蛋白
  • SLIM 蛋白

Protein level used designations for PDLIM2

PDZ and LIM domain protein 2 , PDZ-LIM protein mystique , STAT-interacting LIM protein , mystique , alpha-actinins and filamin-interacting protein

GENE ID SPECIES
213019 Mus musculus
290354 Rattus norvegicus
64236 Homo sapiens
512907 Bos taurus
486123 Canis lupus familiaris
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