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a class of opioid receptors; show selective affinity for the endogenous opioid dynorphin. 再加上，我们可以发Opioid Receptor, kappa 1 试剂盒 (5) 和 Opioid Receptor, kappa 1 蛋白 (3)和数多这个蛋白质的别的产品。
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Human Polyclonal OPRK1 Primary Antibody for ELISA, ICC - ABIN4329272
Li, Chen, Liu-Chen: N-Glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway. in Biochemistry 2007
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Human Polyclonal OPRK1 Primary Antibody for WB - ABIN1881595
Bruijnzeel: kappa-Opioid receptor signaling and brain reward function. in Brain research reviews 2009
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Human Polyclonal OPRK1 Primary Antibody for WB - ABIN317765
Niwa, Rowbotham, Lambert: Evaluation of primary opioid receptor antibodies for use in western blotting. in British journal of anaesthesia 2012
ZFOR3 is a unique model to study kappa opioid receptor functionality
These findings provide evidence that previously demonstrated KOR-mediated reduction in intraocular pressure could be caused, in part, by NO production in both the ciliary body and the trabecular meshwork.
The OPRK1/kappa-opioid receptor pathway was found to be downregulated in lesional skin of psoriasis, correlating positively with itch sensation.
Functional activity of Dynorphin 1-17 and fragments (1-6, 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK (显示 EPHA3 抗体)) cells stably transfected with one of KOP (显示 SPINT2 抗体), MOP (显示 NLN 抗体) or DOP (显示 COPB2 抗体)
These results indicate that KOR can form a heterodimer with B2R (显示 BDKRB2 抗体) and this leads to increased protein kinase A activity by the CREB (显示 CREB1 抗体) signaling pathway, leading to a significant increase in cell proliferation.
that promoter fragments of OPRK1 and OPRM1 (显示 OPRM1 抗体) were able to upregulate gene expression with mild cognitive impairment
Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2 (显示 ARRB2 抗体)-signaling pathway.
Hypoxia inducible factor-1alpha (HIF-1alpha (显示 HIF1A 抗体)) siRNA knocked down the increase of endogenous HIF-1alpha (显示 HIF1A 抗体) messages and diminished the desferrioxamine (DFO)-induced increase of kappa-opioid receptor (hKOR) expression.
genetic association studies in a population in Denmark: Data suggest that carriers/heterozygotes of the C allele (CC/CT) of OPRK SNP rs6473799 report a 30.4% higher mechanical visceral pain tolerance threshold than non-carriers.
Molecular switches of the kappa opioid receptor triggered by 6'-GNTI (显示 MGAT1 抗体) and 5'-GNTI (显示 MGAT1 抗体) have been described.
The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1 (显示 OPRM1 抗体), OPRK1, OPRD1 (显示 OPRD1 抗体)) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone.
findings suggest that SNPs in opioid receptors and the PNOC (显示 PNOC 抗体) genes are associated with NAS (显示 SCN9A 抗体) severity.
The kappa opioid receptor was identified as a key player mediating the effects of buprenorphine in tests sensitive to antidepressant drugs in mice.
This study provides the first evidence for a time- and learning-dependent property of neocortical kappa opioid receptor in facilitating acquisition and consolidation of associative memories.
triazole 1.1 retained the antinociceptive and antipruritic efficacies of a conventional KOR agonist, yet it did not induce sedation or reductions in dopamine release in mice, nor did it produce dysphoria as determined by intracranial self-stimulation
This study reports a cluster of compounds that are highly effective in enhancing remyelination and identifies kappa-opioid receptor (KOR) as a positive regulator for oligodendroglial differentiation, implicating KOR agonism as a potential strategy to accelerate remyelination.
GRK2 (显示 ADRBK1 抗体) upregulation causes kappa-opioid receptor desensitization in diabetic heart
Study showed that Dyn (显示 PDYN 抗体)-A, the endogenous kappa opioid receptor agonist, significantly hyperpolarized and inhibited neurons in the paraventricular nucleus of mouse thalamus
Suggest that mixed cardiac ion channel blockade my mediated the antiarrhythmia actions of kappa-opioid receptor antagonist PD117,302.
Anti-nociception mediated by a KOR agonist is blocked by a DOR agonist
Findings suggest that activation of kappa opioid receptor (kappa-opioid receptor) reduces hyperglycemia in streptozotocin-induced diabetic mice.
findings show that, during prolonged heroin abstinence, delta opioid receptors regulate hedonic homeostasis, while mu opioid receptor (显示 OPRM1 抗体) signaling in serotonergic pathways and kappa opioid receptors together control social behaviors
a class of opioid receptors\; show selective affinity for the endogenous opioid dynorphin
, kappa-type opioid receptor
, opioid receptor, kappa 1
, kappa opioid receptor
, Opiate receptor, kappa-1
, opioid receptor, kappa 2