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NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]..
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our work provides a better understanding of the function of NUSAP1 in aggressive prostate cancers, provides rationale for using NUSAP1 as a prognostic biomarker, and sets the stage for developing improved therapeutic strategies for prostate and other cancers.
NUSAP1 contributes to accurate chromosome segregation by acting as a co-factor for RanBP2 (显示 RANBP2 抗体)-RanGAP1 (显示 RANGAP1 抗体)-UBC9 (显示 UBE2I 抗体) during cell division.
Our results reveal an underlying mechanism by which NuSAP controls kinetochore microtubule dynamics spatially and temporally by modulating the depolymerisation function of MCAK (显示 KIF2C 抗体) in an Aurora B kinase (显示 AURKB 抗体)-dependent manner.
NuSAP governs chromosome oscillation via regulation of Kid, facilitating the Kid-generated polar ejection force. Depletion of NuSAP significantly suppresses the amplitude and velocity of chromosome oscillation.
NUSAP1 may be a crucial biomarker for oral squamous cell carcinoma. down-regulated NUSAP1 expression suppresses tumor proliferation and also enhances anti-tumor effect of paclitaxel by activating apoptotic pathways.
High levels of NuSAP1 expression were related to poor disease-free survival, particularly in triple-negative breast cancer.
A novel association between BRCA1 and NUSAP1 is revealed and a mechanism whereby NUSAP1 is involved in carcinogenesis was elusidated.
High NUSAP1 expression is associated with cervical cancer.
NuSAP is a novel biomarker for prostate cancer recurrence after surgery and its overexpression appears to be driven in part by E2F1 (显示 E2F1 抗体) activation
Phosphorylation of NuSAP by Cdk1 (显示 CDK1 抗体) is an important mechanism to regulate microtubule dynamics during cell cycle progression.
When the in vivo expression of nusap1 was knocked down through antisense oligonucleotide morpholino technology, the morphants of nusap1 showed impaired morphogenesis in the trunk and yolk extension, implying the involvement of Nusap1 in cell migration.
this work has uncovered an ATM-dependent checkpoint pathway that prevents mitotic progression by targeting a microtubule-associated protein, NuSAP.
NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003
nucleolar and spindle-associated protein 1
, nucleolar protein ANKT
, Nucleolar and spindle-associated protein 1-B