Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae) (NSMCE2) ELISA试剂盒

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. 再加上,我们可以发NSMCE2 抗体 (57)NSMCE2 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
小鼠 NSMCE2 NSMCE2 68501 Q91VT1
大鼠 NSMCE2 NSMCE2 299957 Q4V8A0
NSMCE2 286053 Q96MF7
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7 pg/mL 28-1800 pg/mL Typical standard curve 96 Tests 15至18个工作日
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引用最多的NSMCE2 ELISA试剂盒

  1. Human NSMCE2 ELISA Kit for Sandwich ELISA - ABIN819150 : Yusof, Mehde, Mehdi, Raus, Ghazali, Rahman: Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals. in Biomedical and environmental sciences : BES 2015 (PubMed)

适于 NSMCE2 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae) (NSMCE2) interaction partners

  1. SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate chromosome segregation.

Human Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae) (NSMCE2) interaction partners

  1. We demonstrate that Topo2a is SUMOylated in an ICRF193-dependent manner by NSE2 at a novel non-canonical site (K1520) and that K1520 sumoylation is required for chromosome segregation but not the G2 arrest.

  2. Study the fate of collapsed replication forks generated by prolonged hydroxyurea treatment in NSMCE2-deficient cells. Double strand breaks accumulate during rescue by converging forks in normal cells but not in NSMCE2-deficient cells. Un-rescued forks persist into mitosis, leading to increased mitotic DNA damage.

  3. Absence of NSMCE2 affects survival upon topoisomerase II inhibitor etoposide-induced DNA double-strand breaks double-strand breaks.

  4. our study identified novel PVT1-NSMCE2 and CCDC26-NSMCE2 fusion genes that may play functional roles in leukemia.

  5. support a role for NSMCE2 in recovery from DNA damage and raise the possibility that loss of its function produces dwarfism through reduced tolerance of replicative stress

  6. show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1

  7. Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex.

  8. the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells

  9. MMS21 dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression and that this function appears to be independent of SMC6.

NSMCE2 抗原简介

Antigen Summary

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex.The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).

Gene names and symbols associated with NSMCE2

  • NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (Nsmce2) 抗体
  • NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (NSMCE2) 抗体
  • NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog (nsmce2.L) 抗体
  • Smc5-6 complex non-SMC subunit 2 (nse2) 抗体
  • 1110014D18Rik 抗体
  • AI661537 抗体
  • C8orf36 抗体
  • MMS21 抗体
  • Non-SMC element 2 抗体
  • NSE2 抗体
  • RGD1305156 抗体
  • ZMIZ7 抗体

Protein level used designations for NSMCE2

E3 SUMO-protein ligase NSE2 , MMS21 homolog , non-structural maintenance of chromosomes element 2 homolog , non-SMC element 2 homolog , hMMS21 , methyl methanesulfonate sensitivity gene 21 , zinc finger, MIZ-type containing 7 , non-SMC element 2 homolog (MMS21, S. cerevisiae) , Non-structural maintenance of chromosomes element 2

GENE ID SPECIES
68501 Mus musculus
299957 Rattus norvegicus
286053 Homo sapiens
519974 Bos taurus
379272 Xenopus laevis
100724833 Cavia porcellus
2542312 Schizosaccharomyces pombe 972h-
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