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Nemo-Like Kinase 蛋白

(Nemo-Like Kinase (NLK))
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).
Nemo-Like Kinase Protein (NLK) (AA 1-515) (GST tag) Nemo-Like Kinase Protein (NLK) (AA 1-515) (GST tag) Nemo-Like Kinase Protein (NLK) (AA 1-515) (GST tag) (ABIN1312656)

NLK 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA, KAA

Nemo-Like Kinase Protein (NLK) (AA 121-515) (GST tag) Nemo-Like Kinase Protein (NLK) (AA 121-515) (GST tag) Nemo-Like Kinase Protein (NLK) (AA 121-515) (GST tag) (ABIN5569787)

NLK 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active

Nemo-Like Kinase Protein (NLK) (AA 1-515) (His-GST) Nemo-Like Kinase Protein (NLK) (AA 1-515) (His-GST) Nemo-Like Kinase Protein (NLK) (AA 1-515) (His-GST) (ABIN5570569)

NLK 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active

Nemo-Like Kinase 蛋白 by Grade

Find Nemo-Like Kinase 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

Nemo-Like Kinase 蛋白 by Origin

Find Nemo-Like Kinase 蛋白 for a variety of species such as anti-Human Nemo-Like Kinase, anti-Mouse Nemo-Like Kinase, anti-Rat Nemo-Like Kinase. The species listed below are among those available. Click on a link to go to the corresponding products.

Nemo-Like Kinase 蛋白 by Source

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Nemo-Like Kinase 蛋白 by 蛋白类型

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Nemo-Like Kinase 蛋白 by 应用范围

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Nemo-Like Kinase 蛋白 by 生物活性

Find Nemo-Like Kinase 蛋白 with a specific 生物活性. The 生物活性 listed below are among those available. Click on a link to go to the corresponding products.

Popular Nemo-Like Kinase 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
Cat. No. ABIN1312656
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect cells (Sf21)
Validations
  • (2)
Cat. No. ABIN5569787
Quantity 5 μg
Datasheet Datasheet
Reactivity Human
Source Insect cells (Sf9)
Validations
  • (2)
Cat. No. ABIN5570569
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312658
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN7317069
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094173
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131814
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509048
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2727385
Quantity 20 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1509815
Quantity 1 mg
Datasheet Datasheet

Aliases for Nemo-Like Kinase 蛋白

glucose-6-phosphate isomerase (Gpi) 蛋白
nemo like kinase (NLK) 蛋白
nemo like kinase (Nlk) 蛋白
nemo-like kinase, type 1 (nlk1) 蛋白
nemo-like kinase L homeolog (nlk.L) 蛋白
nemo like kinase (nlk) 蛋白
Nemo-Like kinase (nemo-like) 蛋白
nemo-like kinase (nlk) 蛋白
AI194375 蛋白
Amf 蛋白
Gpi1 蛋白
nemo-like 蛋白
nlk 蛋白
NLK 蛋白
nlk1 蛋白
nlk2 蛋白
nlkb 蛋白
RGD1561602 蛋白
Xnlk 蛋白
zgc:111875 蛋白
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