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The protein encoded by NPPC is proteolytically processed to form a secreted hormone of the natriuretic peptide family. 再加上，我们可以发Natriuretic Peptide Precursor C 试剂盒 (4)和数多这个蛋白质的别的产品。
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C-type natriuretic peptide (CNP)administration significantly decreased the secretion and expression of MMP-2 (显示 MMP2 抗体) and MMP-9 (显示 MMP9 抗体) in the cultured mesangial cells ; (2) the secretion and expression of TIMP-1 (显示 TIMP1 抗体) progressively elevated after treatment with CNP (显示 CNP 抗体) for 24 and 48 h, whereas declined at later time point; (3) CNP (显示 CNP 抗体) expression was negatively correlated with MMP-2 (显示 MMP2 抗体) and MMP-9 (显示 MMP9 抗体) expression.
CNP (显示 CNP 抗体) level in pericardial fluid is a more sensitive marker of LV dysfunction than CNP (显示 CNP 抗体) levels in plasma in coronary artery disease patients undergoing coronary artery bypass grafting.
Data suggest mutations in NPR2 (显示 NPRL2 抗体) in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2 (显示 NPRL2 抗体); A488P mutation sets phosphorylation as requirement for CNP (显示 CNP 抗体)-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 (显示 NPRL2 抗体) = atrial natriuretic factor (显示 NPPA 抗体) receptor B; CNP (显示 CNP 抗体) = C-type natriuretic peptide)
CNP (显示 CNP 抗体) may play a more important role than BNP (显示 BNC2 抗体) and ANP (显示 NPPA 抗体) related peptides, as risk marker of obesity
CNP (显示 CNP 抗体) and FGF-23 (显示 FGF23 抗体) act through a close or reciprocal pathway and are in agreement with recent studies demonstrating a down-regulatory role of the mitogen-activated protein kinase (显示 MAPK1 抗体) activity by CNP (显示 CNP 抗体)
CNP (显示 CNP 抗体)/NPR-B (显示 NPR2 抗体) can affect sperm motility and acrosome reaction, thus regulating the reproductive function of males
CNP (显示 CNP 抗体) levels rose after paroxysmal supraventricular tachycardia and continued to rise after the termination.
examined whether CNP reduces hyaluronan production and export via members of the multidrug resistance protein (MRP) and diminishes pro-inflammatory effects in chondrocytes
Plasma CNP (显示 CNP 抗体) might serve as a useful predictor for the therapeutic efficacy of metoprolol on postural tachycardia syndrome in children.
CNP (显示 CNP 抗体)/proCNP could be new markers in human prostate cancer
CNP and BNP (显示 BNC2 抗体) serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals.
The first intron in the CNP sequence does not contain any additional enhancer-binding sites. However, the signal sequence is indispensable for secretion of CNP and its appropriate physiological function.
Inhibition of restenosis without compromising reendothelialization makes use of gene transfer into endothelial cells and muscle, smooth, vascular cells by administration of CNP.
Regional differences in BNP (显示 BNC2 抗体) and CNP expression were observed in myocardium with sustained left ventricular dyssynchronous contraction.
Data suggest natriuretic peptide precursor C (NPPC) can regulate oogenesis/gap junction mediated communication between oocytes and cumulus cells; here, NPPC is used in non-pharmacological coordination of meiotic prophase in vitro oocyte maturation.
E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2 (显示 NPRL2 抗体))
CNP (显示 CNP 抗体) activates bone turnover and remodeling in vivo and possibly accelerates fracture healing in a mouse model.
The up-to-day world-wide data about the structure, distribution, and physiological effects of the most poorly known among the natriuretic peptides--the C-type (CNP (显示 CNP 抗体))--are summarized in the review.
Connexin mimetics directed against connexin-43 (Cx43 (显示 GJA1 抗体) CMP (显示 MATN1 抗体)) overcame NPPC-mediated meiotic arrest in both isolated cumulus oocyte complexes and antral follicles.
CNP (显示 CNP 抗体)/NPR-C (显示 NPR3 抗体) pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders
Data indicate an important, previously neglected, role of NEP (显示 MME 抗体) for regulation of luminal factors in the epididymis and suggest a novel role for CNP (显示 CNP 抗体)/guanylyl cyclase B in the epididymal epithelium
CNP (显示 CNP 抗体) overexpression in chondrocytes can prevent endochondral growth delay and protect against cartilage damage in a mouse model of inflammatory arthritis.
Data suggest that intracerebroventricular administration of C-type natriuretic peptide (CNP-22 or CNP (显示 CNP 抗体)-53) has anorexigenic effect on hypothalamic neurons via activation of melanocortin/melanocortin receptor signal transduction.
CNP (显示 CNP 抗体)/NPR2 (显示 NPRL2 抗体) signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin (显示 AREG 抗体)/EGFR (显示 EGFR 抗体) signaling pathway suppresses this signal by downregulating Nppc expression.
we show that CNP (显示 CNP 抗体) plays important region-specific roles in the GI tract of mice.
The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate chondrocytes and may also be vasoactive and natriuretic.
C-type natriuretic peptide
, natriuretic peptide precursor C
, natriuretic peptide precursor type C
, C-type natriuretic peptide 3