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MLF1 encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. 再加上，我们可以发MLF1 抗体 (120) 和 MLF1 蛋白 (8)和数多这个蛋白质的别的产品。
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Mutation in HTT (显示 HTT ELISA试剂盒) causes Huntington's disease (HD); aggregates of mutated HTT (显示 HTT ELISA试剂盒) cause apoptosis in neurons of HD patients. Data suggest that both MLF1 and MLF2 preferentially interact with mutated N-terminal HTT (显示 HTT ELISA试剂盒); MLF1/MLF2 reduce number of neurons (Neuro2A cell line) containing mutant HTT (显示 HTT ELISA试剂盒) aggregates and subsequent apoptosis. (HTT (显示 HTT ELISA试剂盒) = Huntingtin (显示 HTT ELISA试剂盒) protein; MLF = myeloid leukemia (显示 BCL11A ELISA试剂盒) factor)
The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1 (显示 HAX1 ELISA试剂盒)/HtrA2-OMI (显示 HTRA2 ELISA试剂盒)/PARL (HOP (显示 STIP1 ELISA试剂盒)) mitochondrial complex to modulate cell survival.
SNP associated with neuroblastoma resides upstream of the MLF1. Gene silencing of MLF1 in neuroblastoma cells results in significant growth inhibition.
Data indicte that acute myeloid leukemia (显示 BCL11A ELISA试剂盒) (AML (显示 RUNX1 ELISA试剂盒)) with NPM1 (显示 NPM1 ELISA试剂盒)-MLF1 and AML (显示 RUNX1 ELISA试剂盒) with NPM1 (显示 NPM1 ELISA试剂盒) mutations showed similar immunophenotypical and molecular features, including gene mutation patterns and gene expression profiling (GEP).
The subcellular localization of full-length human MLF1 is 14-3-3epsilon-independent.
changes in the subcellular localization of NPM (显示 NPM1 ELISA试剂盒), due to alterations in the relative abundance of NPM (显示 NPM1 ELISA试剂盒) and NPM (显示 NPM1 ELISA试剂盒)-MLF1 proteins, may contribute to the enhanced myeloid progenitor activity of Npm (显示 NPM1 ELISA试剂盒) +/- cells
Data present the high-resolution crystal structure of this binding motif [MLF1(29-42)pSer34] in complex with 14-3-3epsilon and analyse the interaction with isothermal titration calorimetry.
MLF1 gene rearrangement is associated with acute myeloid leukemia (显示 BCL11A ELISA试剂盒).
phosphorylation of 14-3-3 (显示 YWHAQ ELISA试剂盒) binding site by MADM (显示 ADAM10 ELISA试剂盒)
These findings suggest that an NPM/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS and AML with multilineage dysplasia, and that cases with NPM/MLF1 may be clinically distinct from other MDS-associated disease
Ectopically expressed MLF1 could be responsible for the pathological apoptosis in early myelodysplastic syndrome (MDS) patients.
Mlf1 translocates between nucleus and cytoplasm, associates with a novel hnRNP, and influences gene expression
shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
myeloid leukemia factor 1
, myelodysplasia-myeloid leukemia factor 1
, hematopoietic lineage switch 7