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Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. 再加上，我们可以发MPZL2 抗体 (64) 和 MPZL2 蛋白 (10)和数多这个蛋白质的别的产品。
CLCA2 (显示 CLCA2 ELISA试剂盒) links junctional adhesion molecule (显示 AMICA1 ELISA试剂盒) EVA1, to cytosolic signaling proteins that modulate proliferation and differentiation.
Findings highlight Eva1 as a novel regulator of GIC function and also provide new mechanistic insight into the role of noncanonical NF-kappaB (显示 NFKB1 ELISA试剂盒) activation in GIC.
EVA (显示 SLC26A4 ELISA试剂盒) is expressed in human choroid plexus epithelial cells and CD4 (显示 CD4 ELISA试剂盒) T lymphocytes and regulates CD4 (显示 CD4 ELISA试剂盒)+ T lymphocyte adhesion to human choroid plexus epithelial cells in vitro. These data suggest a novel mechanism to regulate CNS immune surveillance.
EVA deficiency results in increased experimental autoimmune encephalomyelitis disease severity. EVA-knockout Mice have normal immune system development and choroid plexus morphology.
modulation of Eva1 expression in thymocytes is crucial for lymphocyte physiological developmental progression and stromal differentiation
These results suggest that EVA expressed in choroid plexus cells may regulate the permeability of the blood-CSF (显示 CSF2 ELISA试剂盒) barrier.
Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain\; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene.
epithelial V-like antigen 1
, myelin protein zero-like 2
, myelin protein zero-like protein 2