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MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. 再加上，我们可以发MYCN 蛋白 (7) 和 MYCN 试剂盒 (6)和数多这个蛋白质的别的产品。
Showing 10 out of 98 products:
Human Monoclonal MYCN Primary Antibody for ChIP, CyTOF - ABIN152254
Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. in The Journal of biological chemistry 2011
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Mouse (Murine) Polyclonal MYCN Primary Antibody for ICC, IF - ABIN256650
Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. in Developmental cell 2005
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Human Polyclonal MYCN Primary Antibody for WB - ABIN391590
Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. in Molecular cancer research : MCR 2015
Human Polyclonal MYCN Primary Antibody for IF (p), IHC (p) - ABIN760676
Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. in Oncotarget 2016
N-MYC is in the downstream-regulated gene family in reprogramming cancer metabolism under hypoxia [review]
SNHG1 is up-regulated by MYCN amplification and could be a potential prognostic biomarker for high-risk neuroblastoma (显示 ARHGEF16 抗体) intervention.
MYCN expression is a marker indicative of likely clinical sensitivity to mTOR (显示 FRAP1 抗体) inhibition in neuroblastoma (显示 ARHGEF16 抗体) cells
Results show that MYCN and LSD1 (显示 KDM1A 抗体) co-localize at NDRG1 (显示 NDRG1 抗体) promoter and repress its expression in neuroblastoma (显示 ARHGEF16 抗体) cells.
Data indicate cross-talks between MYCN and beta-catenin (显示 CTNNB1 抗体) signalling, which repress normal beta-catenin (显示 CTNNB1 抗体) mediated transcriptional regulation.
Data show that transcription factor activating enhancer binding protein-4 (TFAP4) is a direct transcriptional target of MYCN in neuroblastoma (显示 ARHGEF16 抗体) and that high levels of this transcription factor are associated with poor clinical outcome in this disease.
data extend knowledge on roles of MCPIP1 (显示 ZC3H12A 抗体) in our model and link the protein to regulation of expression and stability of MYCN through decrease of signaling via Akt (显示 AKT1 抗体)/mTOR (显示 FRAP1 抗体) pathway.
Data show that MYCN and its regulated microRNAs acted together to repress the tumor suppressor genes.
Common genetic variation predisposes to different neuroblastoma (显示 ARHGEF16 抗体) genotypes, including the likelihood of somatic MYCN-amplification. [meta-analysis]
Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (显示 RB1 抗体) gene.
interactions of NF-kappaB (显示 NFKB1 抗体) and N-myc with GLT-1/EAAT2 (显示 SLC1A2 抗体) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.
beta-catenin (显示 CTNNB1 抗体) cooperates with the transcription factor Myc (显示 MYC 抗体) to activate the progenitor renewal program.
we report the isolation and propagation of neuroblastoma (显示 ARHGEF16 抗体) sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma (显示 ARHGEF16 抗体) with MYCN amplification
miR (显示 MLXIP 抗体)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.
the role of N-myc in mouse lens development, was examined.
Using comparative genomic hybridization, authors found that NCC (显示 SLC12A3 抗体)-derived NBL (显示 NUMBL 抗体) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (显示 NUMBL 抗体) including 17q gain, 2p gain and loss of 1p36.
a Mycn target gene encoding the miR (显示 MLXIP 抗体) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.
The findings reveal a PLK1 (显示 PLK1 抗体)-Fbw7 (显示 FBXW7 抗体)-Myc (显示 MYC 抗体) signaling circuit that underlies tumorigenesis and validate PLK1 (显示 PLK1 抗体) inhibitors, alone or with Bcl2 (显示 BCL2 抗体) antagonists, as potential effective therapeutics for MYC (显示 MYC 抗体)-overexpressing cancers.
ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (显示 MMRN1 抗体)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.
Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.
In MYCN transgenic fish, Gab2 (显示 GAB2 抗体) overexpression activated the Shp2 (显示 PTPN11 抗体)-Ras (显示 RAB1A 抗体)-Erk (显示 MAPK1 抗体) pathway, enhanced neuroblastoma (显示 ARHGEF16 抗体) induction, and increased tumor penetrance.
The authors demonstrate in zebrafish that nf1 (显示 NF1 抗体) loss leads to aberrant activation of RAS (显示 RAB1A 抗体) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (显示 ARHGEF16 抗体) in nf1 (显示 NF1 抗体)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (显示 NF1 抗体) mutant embryos.
At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
N-myc proto-oncogene protein
, class E basic helix-loop-helix protein 37
, neuroblastoma MYC oncogene
, neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
, oncogene NMYC
, v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
, N-myc protein
, neuroblastoma myc-related oncogene 1
, Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc)
, Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc)
, N-myc-like protein
, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
, MYCN proto-oncogene, bHLH transcription factor S homeolog
, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog
, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a