Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) ELISA试剂盒

The protein encoded by MAP4K4 is a member of the serine/threonine protein kinase family. 再加上,我们可以发MAP4K4 抗体 (151)MAP4K4 蛋白 (6)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
MAP4K4 9448 O95819
小鼠 MAP4K4 MAP4K4 26921 P97820
大鼠 MAP4K4 MAP4K4 301363  
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Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

  1. an anti-cancer effect of microRNA-141 on breast cancer by cytotoxic CD4+ T cells through MAP4K4 expression.

  2. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells.

  3. RBM4-SRSF3-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 signaling pathway.

  4. these findings identify MAP4K4 as a novel MAPK/ERK pathway regulator in lung adenocarcinoma that is required for lung adenocarcinoma maintenance.

  5. This report identifies HGK methylation/downregulation in T cells as a potential biomarker for non-obese type 2 diabetes

  6. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.

  7. of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 gene is associated with T2DM in a Chinese Han population, and MAP4K4 gene variants may contribute to the risk toward the development of T2DM

  8. Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D.

  9. MAP4K4 promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells

  10. miR-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4

  11. The results of the present study suggested that inhibition of MAP4K4 may be a therapeutic strategy for gastric cancer.

  12. loss of MAP4K4 function suppressed pathological angiogenesis in disease models, identifying MAP4K4 as a potential therapeutic target

  13. that MAP4K4, a known mediator of inflammation, is involved in KS aetiology by regulating KSHV lytic reactivation

  14. results reveal a key target of SOX2 expression and highlight the unexpected context-dependent role for MAP4K4, a pluripotent activator of several mitogen-activated protein kinase pathways, in regulating tumor cell survival.

  15. TRAF1.NIK is a central complex linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex

  16. Common polymorphisms in MAP4K4 are associated with insulin resistance and beta-cell dysfunction, possibly via this gene's role in inflammatory signaling.

  17. Elevated MAP4K4 expression is closely associated with lung adenocarcinoma progression with independent prognostic value in predicting overall survival for patients with lung adenocarcinoma.

  18. MAP4K4 overexpression is an independent predictor of poor prognosis of Hepatocellular Carcinoma patients, and inhibition of its expression might be of therapeutic significance

  19. Data show that down-regulation of hepatocyte progenitor kinase-like kinase (HGK) can obviously inhibit the migration and invasion of HepG2 cells in vitro, and suggest that HGK may be a new therapeutic target for treatment of hepatocellular carcinoma.

  20. interaction with GBP3

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

  1. Study identified a novel splicing network composed of RBM4a, SRSF3, and MAP4K4 in brown adipogenesis and subsequently manipulating the effect of downstream JNK signaling which contributes to insulin resistance and reduced metabolism.

  2. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells.

  3. Blood endothelial Map4k4 promotes vascular dysfunction and impairs glucose homeostasis in adult animals, lymphatic endothelial Map4k4 is required to maintain lymphatic vascular integrity and regulate immune cell trafficking in obesity.

  4. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.

  5. These results demonstrate that protein kinase Map4k4 drives obesity-induced hyperinsulinemia and insulin resistance in part by promoting insulin secretion from beta cells in mice.

  6. These results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis.

  7. Mice with Map4k4 deleted in Myf5-positive tissues, including all skeletal muscles tested, were protected from obesity-induced glucose intolerance and insulin resistance.

  8. HGK/MAP4K4 deficiency has a role in inducing TRAF2 stabilization and Th17 differentiation leading to insulin resistance

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  10. microtubules can deliver MAP4K4 toward focal adhesions through ending binding 2

  11. MAP4K4 is essential for CD4+ T cell proliferation and activation in vitro through suppressing PKC-theta activation.

  12. Map4k4 inhibits adipose lipogenesis by suppression of Srebp-1 in an AMPK- and mTOR-dependent but JNK-independent mechanism.

  13. Expression of a Map4k4 kinase-inactive mutant enhances myotube formation, suggesting that the kinase activity of Map4k4 is essential for its inhibition of muscle differentiation.

  14. MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic beta-cells.

  15. These findings suggest that scorpion venom induces insulin resistance by mechanisms involving TNF-alpha-dependent Map4k4 kinase activation in the adipose tissue.

  16. These data together with previous reports on extramedullary hemopoiesis in RelB-deficient mice suggest that NIK-RelB signaling may be involved in the suppression of extramedullary hemopoiesis in adult mice.

  17. inhibitory effect of the NIK aly mutation on the process of osteoclast differentiation is, at least in part, closely linked to the alternative NF-kappaB signaling pathway.

  18. Map4k4 negatively regulates PPARgamma post-transcriptionally, by attenuating mTOR signaling and a 4E-BP1-dependent mechanism

  19. These results reveal a MAP4K4/NIK-dependent signaling pathway that potently inhibits PPARgamma-responsive gene expression

  20. TNFalpha selectively stimulates the expression of a key component of its own signaling pathway, Map4k4, through a TNFR1-dependent mechanism that targets the transcription factors c-Jun and ATF2

Cow (Bovine) Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

  1. study identified single nucleotide polymorphisms at different locations of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) gene of cattle and several of them were significantly associated with the somatic cell score and other different milk traits

MAP4K4 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with MAP4K4

  • mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) 抗体
  • mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) 抗体
  • 9430080K19Rik 抗体
  • AU043147 抗体
  • AU045934 抗体
  • AW046177 抗体
  • FLH21957 抗体
  • HGK 抗体
  • MEKKK4 抗体
  • Nik 抗体

Protein level used designations for MAP4K4

HPK/GCK-like kinase HGK , MAPK/ERK kinase kinase kinase 4 , MEK kinase kinase 4 , Ste20 group protein kinase HGK , hepatocyte progenitor kinase-like/germinal center kinase-like kinase , nck-interacting kinase , MEKKK 4 , NCK interacting kinase , mitogen activated protein kinase kinase kinase kinase 4

GENE ID SPECIES
9448 Homo sapiens
26921 Mus musculus
418714 Gallus gallus
100516547 Sus scrofa
509109 Bos taurus
301363 Rattus norvegicus
481331 Canis lupus familiaris
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