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MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. 再加上，我们可以发MAPK8IP1 抗体 (74) 和 和数多这个蛋白质的别的产品。
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Phosphorylation of KLC1 (显示 KLC1 蛋白) at Thr466 increased in aged brains, and JIP1 binding to kinesin-1 decreased, suggesting that APP (显示 APP 蛋白) transport is impaired by aging. Authors conclude that phosphorylation of KLC1 (显示 KLC1 蛋白) at Thr466 regulates the velocity of transport of APP (显示 APP 蛋白) by kinesin-1 by modulating its interaction with JIP1b.
It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK (显示 MAPK8 蛋白) signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.
Enhanced fast-velocity and efficient high-frequency APP (显示 APP 蛋白) anterograde transport observed in neurons are mediated by novel roles of JIP1b.
a simple yet modular mechanism for JIP1 scaffold assembly in mammals
There is a collaborative relationship between JIP1 and AKT (显示 AKT1 蛋白) that is required for axon growth and can be regulated by changes in neuronal activity.
identify plenty of SH3 (POSH (显示 SH3RF1 蛋白)) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 (显示 MAPK8 蛋白) activation in CD8 (显示 CD8A 蛋白)(+) T cells.
The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP (显示 APP 蛋白) transport in neurons.
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (显示 MAP3K11 蛋白) interaction with JIP1 scaffold protein (显示 HOMER1 蛋白) in cytokine-induced pancreatic beta cell death
JIP1 forms a trimetric complex with RBP-Jk (显示 RBPJ 蛋白) and Notch1 (显示 NOTCH1 蛋白)-IC, prevents physical association between Notch1 (显示 NOTCH1 蛋白)-IC and RBP-Jk (显示 RBPJ 蛋白), sequesters RBP-JK (显示 RBPJ 蛋白) in the cytoplasm, and suppresses the Notch1 (显示 NOTCH1 蛋白) signaling pathway.
Data suggest that JIP1-mediated JNK (显示 MAPK8 蛋白) activation plays a critical role in metabolic stress regulation of the JNK (显示 MAPK8 蛋白) signaling pathway.
All binary complexes (KLC1 (显示 KLC1 蛋白):APP (显示 APP 蛋白), KLC1 (显示 KLC1 蛋白):JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 (显示 KLC1 蛋白) and JIP1 may take part in APP (显示 APP 蛋白) transport in Alzheimer's disease patients.
analysis of the role of JIP1 in APP (显示 APP 蛋白) transport; knockdown of JIP1 did not affect either amyloid precursor protein (显示 APP 蛋白) transport or amyloid-beta peptide production
Data show that small GTPase (显示 RACGAP1 蛋白) RALA (显示 rala 蛋白) regulates formation of a JIP1 (C-Jun (显示 JUN 蛋白)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (显示 MAPK8 蛋白) signaling toward FOXO4 (显示 FOXO4 蛋白) (forkhead box O transcription factor) in response to reactive oxygen species (ROS (显示 ROS1 蛋白)).
In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.
Data suggest that caspase 3 (显示 CASP3 蛋白)-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK (显示 MAPK8 蛋白) signalling during apoptotic cell death.
Data show that mechanical stress of urothelial cells activates in vivo JNK (显示 MAPK8 蛋白), as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 (显示 GJB2 蛋白) may be directly regulated by the AP-1 (显示 FOSB 蛋白) complex.
results suggest that JIP (显示 SMAD4 蛋白)-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP (显示 APP 蛋白), and that the JNK (显示 MAPK8 蛋白) signaling pathway may regulate the phosphorylation of this cargo protein through the JIP (显示 SMAD4 蛋白)-1b scaffold
JIP1 may act as an Akt1 (显示 AKT1 蛋白) scaffold, which regulates the enzymatic activity of Akt1 (显示 AKT1 蛋白) and can exert signaling effects independent of JNK (显示 MAPK8 蛋白) activity
JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
mitogen-activated protein kinase 8 interacting protein 1
, c-Jun-amino-terminal kinase-interacting protein 1-like
, C-Jun-amino-terminal kinase-interacting protein 1
, JNK MAP kinase scaffold protein 1
, JNK-interacting protein 1
, mitogen activated protein kinase 8 interacting protein 1
, mitogen-activated protein kinase 8-interacting protein 1
, protein kinase, mitogen-activated 8 interacting protein
, JIP-1-related protein
, mitogen activated protein kinase 8 interacting protein
, PRKM8 interacting protein
, islet-brain 1
, islet brain 1