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This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. 再加上，我们可以发Mitochondrial Fission Factor 蛋白 (7)和数多这个蛋白质的别的产品。
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Human Polyclonal MFF Primary Antibody for ICC, IF - ABIN4334023
Li, Alavian, Lazrove, Mehta, Jones, Zhang, Licznerski, Graham, Uo, Guo, Rahner, Duman, Morrison, Jonas: A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. in Nature cell biology 2013
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We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations
membrane-anchored Mff differentially regulates various Drp1 (显示 CRMP1 抗体) isoforms.
Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC).
loss of Mff results in failure of Parkin (显示 PARK2 抗体) translocation and final clearance of damaged mitochondria
Mitochondrial fission factor (MFF) mRNA is a direct target of miR (显示 MLXIP 抗体)-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region.
MiD49 (显示 SMCR7 抗体) and MiD51 (显示 SMCR7L 抗体) can act independently of Mff and Fis1 (显示 FIS1 抗体) in Drp1 (显示 CRMP1 抗体) recruitment and suggest that they provide specificity to the division of mitochondria.
TRAP1 (显示 TRAP1 抗体) controls mitochondrial fusion/fission balance through Drp1 (显示 CRMP1 抗体) and Mff expression.
PEX11 proteins attract both Mff and human Fis1 (hFis1 (显示 FIS1 抗体)) to their site of action.
MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS (显示 ROS1 抗体) production, and the onset of autophagy and mitophagy.
MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
MiD51 (显示 SMCR7L 抗体) can suppress Mff-dependent enhancement of Drp1 (显示 CRMP1 抗体) GTPase (显示 RACGAP1 抗体) activity.
Mff cannot bind to assembly-deficient mutants of Drp1 (显示 CRMP1 抗体), suggesting that Mff selectively interacts with higher-order complexes of Drp1 (显示 CRMP1 抗体).
These findings provide a mechanism wherein the multimeric states of both Mff and Drp1 (显示 CRMP1 抗体) regulate their collaborative interaction.
Ablating Mfn1 (显示 MFN1 抗体) eliminates the cardiac-related lethality of Mff knockout mice.
Mitochondrial fission factor has been identified as a new AMPK (显示 PRKAA1 抗体) substrate.
This study reveals a novel model of mitochondrial fission regulation, which is composed of miR (显示 MLXIP 抗体)-761 and mitochondrial fission factor
immunofluorescence analysis of Drp1 (显示 CRMP1 抗体) suggests that Fis1 (显示 FIS1 抗体) and Mff are important for the number and size of Drp1 (显示 CRMP1 抗体) puncta on mitochondria.
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.
mitochondrial fission factor homolog B
, mitochondrial fission factor homolog A
, mitochondrial fission factor
, Uncharacterized protein C2orf33 homolog