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The protein encoded by MID1 is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. 再加上，我们可以发MID1 抗体 (64) 和 MID1 试剂盒 (8)和数多这个蛋白质的别的产品。
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Data show that protein phosphatase-2A (PP2A (显示 PPP2R4 蛋白)) was upregulated in lung adenocarcinoma cell lines that were transfected with midline 1 E3 ubiquitin-protein ligase (显示 UBE2K 蛋白) (MID1)-siRNA, suggesting MID1 negatively regulates PP2A (显示 PPP2R4 蛋白) in lung adenocarcinoma.
identified four miRNAs, miR (显示 MLXIP 蛋白)-19, miR (显示 MLXIP 蛋白)-340, miR (显示 MLXIP 蛋白)-374 and miR (显示 MLXIP 蛋白)-542 that bind to the 3'-UTR of the MID1 mRNA. These miRNAs not only regulate MID1 expression but also mTOR (显示 FRAP1 蛋白) signaling and translation of disease associated mRNAs and could therefore serve as potential drugs for future therapy development
Our data reveal a novel role for MID1 and for atypical ubiquitination in balancing BRAF35 (显示 HMG20B 蛋白) presence, and likely its activity, within nuclear and cytoplasmic compartments
P151L MID1 mutation is associated with X-linked Opitz Syndrome.
the coiled-coil and COS domain (CC-COS) bind to microtubules, demonstrating for the first time that MID1 can directly associate with the microtubules
Osx is upregulated in patients with Ossification of the posterior longitudinal ligament.
A130T/V mutations within the MID1 zinc-binding Bbox1 (显示 BBOX1 蛋白) domain affects protein folding.
MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 (显示 BBOX1 蛋白) domain disrupt polyubiquitination of alpha4 but not of PP2Ac (显示 PPP2CA 蛋白) in X-linked Opitz syndrome.
TRAIL regulates MID1 and TSLP (显示 TSLP 蛋白), inflammation, fibrosis, smooth muscle hypertrophy, and expression of inflammatory effector chemokines and cytokines in experimental eosinophilic esophagitis.
These studies provide insight into the mechanism by which mutations observed in X-linked Opitz G syndrome affect the structure and function of the MID1 Bbox1 (显示 BBOX1 蛋白) domain
we show that MID1 controls exocytosis of lytic granules and cytotoxicity in murine cytotoxic lymphocytes
X-linked microtubule-associated protein (显示 SPAG5 蛋白), Mid1, regulates axon development.
MID1 inhibition also limited rhinovirus-induced exacerbation of allergic airway disease
Thus, lack of Mid1 causes a misspecification of the midbrain/cerebellar boundary that results in an abnormal development of the most anterior cerebellar lobes.
Analysis of Mid1, Hccs (显示 HCCS 蛋白), Arhgap6 (显示 ARHGAP6 蛋白), and Msl3l1 (显示 MSL3 蛋白) in X-linked polydactyly (Xpl) and Patchy-fur (Paf (显示 PAF 蛋白)) mutant mice
SHH (显示 SHH 蛋白)-dependent E-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 (显示 PAX6 蛋白) during visual system development.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing\; however, the full-length nature of some of the variants has not been determined.
RING finger protein 59
, midline 1 RING finger protein
, putative transcription factor XPRF
, tripartite motif protein TRIM18
, tripartite motif-containing protein 18
, zinc finger on X and Y, mouse, homolog of
, Finger on X and Y (in rat only on X)
, E3 ubiquitin-protein ligase Midline-1
, midline 1 (Opitz/BBB syndrome)