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alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b. 再加上，我们可以发Meprin A, alpha (PABA Peptide Hydrolase) 抗体 (83) 和 Meprin A, alpha (PABA Peptide Hydrolase) 蛋白 (12)和数多这个蛋白质的别的产品。
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no significant dentin malformation was observed in Mep1b (显示 MEP1B ELISA试剂盒) (-/-) or Mep1a (-/-) deficient mice.
meprin alpha and meprin beta (显示 MEP1B ELISA试剂盒) join the modulators of Reelin (显示 RELN ELISA试剂盒) signalling as they cleave Reelin (显示 RELN ELISA试剂盒) at a specific site and are upregulated under specific pathological conditions.
While meprin A only cleaved protein kinase A (PKA) catalytic subunit beta1, meprin B (显示 MEP1B ELISA试剂盒) cleaved all three PKA catalytic isoforms.
meprin alpha and meprin beta (显示 MEP1B ELISA试剂盒) are unique in their ability to process and release both C- and N-propeptides from type I procollagen (显示 COL1A2 ELISA试剂盒) in vitro and in vivo
the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock
Absence of meprin A aggravates chronic inflammation and lack of meprin B (显示 MEP1B ELISA试剂盒) affords some protection from injury. Manipulation of expression of meprin gene products may have therapeutic potential.
meprin-alpha may play a role in the pathogenesis of diabetic nephropathy and the benefits of ACE (显示 ACE ELISA试剂盒) inhibitor therapy
meprin A, a multimeric metalloprotease expressed in the brush borders of kidney proximal tubules initially truncates mouse BNP in the N terminus to mBNP7-32
meprin alpha/beta null (alpha(-/-)/beta(-/-)) mice had decreased prevalence of resident monocytes and natural killer (NK) cells in blood, with a concomitant accumulation of inflammatory monocytes and NK cells in bone marrow.
MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.
Mep1A is overexpressed in most hepatocellular carcinomas and induces tumor cell migration and invasion. Mep1A expression is regulated by Reptin, and Mep1A mediates Reptin-induced migration.
In this review we report on recent findings that summarize the complex molecular regulation of meprins, particular folding, activation and shedding. Dysregulation of meprin alpha and meprin beta (显示 MEP1B ELISA试剂盒) is often associated with pathological conditions such as neurodegeneration, inflammatory bowel disease and fibrosis
Results showed that MEP1A expression was elevated in colorectal cancer (CRC (显示 CALR ELISA试剂盒)) tissues at both the mRNA and protein levels, and provided evidence for its functionally crucial role in CRC (显示 CALR ELISA试剂盒) carcinogenesis as tumor proliferation and invasion.
Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin (显示 INS ELISA试剂盒) metabolism in overweight/obese central European women with polycystic ovary syndrome.
Meprin metalloproteases A and B inactivate interleukin 6 (显示 IL6 ELISA试剂盒)
Proteolytically active meprinalpha leads to an increase in EGFR (显示 EGFR ELISA试剂盒) and ERK1/2 (显示 MAPK1/3 ELISA试剂盒) phosphorylation and subsequently enhances cell proliferation and migration
The present results indicate that a TNF-alpha (显示 TNF ELISA试剂盒)-mediated down-regulation of CDX2 (显示 CDX2 ELISA试剂盒) can be related to suppressed expression of MEP1A during intestinal inflammation.
Meprin-alpha activity is regulated differently in primary tumors and metastases of colorectal cancer. By virtue of its pro-migratory and pro-angiogenic activity, meprin-alpha may promote tumor progression in colorectal cancer.
Cystatin C (显示 CST3 ELISA试剂盒) was an inhibitor for human meprin alpha(K(i) = 8.5 x 10(-6) M) but, interestingly, not for meprin beta (显示 MEP1B ELISA试剂盒).
activation in colorectal cancer triggered by the plasminogen (显示 PLG ELISA试剂盒)-activating system
alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b
, endopeptidase-24.18 subunit alpha
, meprin A alpha
, meprin A subunit alpha
, meprin A alpha-subunit
, meprin alpha
, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha
, PABA peptide hydrolase
, PPH alpha
, bA268F1.1 (meprin A alpha (PABA peptide hydrolase))