Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A 蛋白 (MGAT4A)

MGAT4A encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus.

列出全部蛋白 基因 基因ID UniProt
小鼠 MGAT4A MGAT4A 269181 Q812G0
 MGAT4A MGAT4A 11320 Q9UM21
大鼠 MGAT4A MGAT4A 367252 Q5M854
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50至55个工作日
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更多Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A (MGAT4A)互动伙伴

Mouse (Murine) Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A (MGAT4A) interaction partners

  1. our results suggest that let-7c may inhibit the metastatic ability of Hca-F cells, at least partially, via repressing Mgat4a activity.

  2. Mutagenesis of this gene encoding GnT-4a glycosyltransferase (显示 GTDC2 蛋白) is studied and its association with Diabetes type 2.

Human Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A (MGAT4A) interaction partners

  1. GnT-IVa may contribute to the malignancy of choriocarcinoma by promoting cell adhesion, migration and invasion through glycosylation of integrin beta1 and LAMP-2 (显示 LAMP2 蛋白).

  2. Data suggest microRNA-424 regulates expression of MGAT4A (mannoside beta-1,4-N-acetylglucosaminyltransferase (显示 GCNT2 蛋白) A), OGT (O-linked N-acetylglucosamine transferase (显示 OGT 蛋白)), and GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13 (显示 GALNT13 蛋白)) in mammary epithelium.

  3. Findings suggest that GnT-IVa is involved in regulating invasion of choriocarcinoma through modifications of the oligosaccharide chains of beta1 integrin.

  4. upregulation of mannosyl (alpha-1,3-)-glycoprotein beta (显示 GYPC 蛋白)-1,4-N-acetyl-glucosaminyl-transferase is associated with metastatic colorectal carcinoma

  5. analysis of expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer

  6. GnT-IVa is more active than GnT-IVb (显示 MGAT4B 蛋白) under physiological conditions and it primarily contributes to the biosynthesis of N-glycans.

  7. We investigated mRNA levels of glycosyltransferases, namely, N-acetylglucosaminyltransferase (显示 GCNT2 蛋白) a (GnT)-IVa, and found that (GnT)-IVa expression was decreased in HLE (显示 ELANE 蛋白)-cells Epirubicin resistant.

  8. The results of this work suggest that in T2D subjects, high levels of glucose and triglycerides are accompanied by an increase on MGAT4A mRNA levels and WBC count; condition that suggests a pro-inflammatory state due to a chronic metabolic stress.

  9. GNT-IV (显示 MGAT4B 蛋白) genetic variation is not associated with gastric cancer.

蛋白简介Mannosyl (Alpha-1,3-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A (MGAT4A)

蛋白简介

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.

Gene names and symbols associated with MGAT4A

  • mannoside acetylglucosaminyltransferase 4, isoenzyme A (Mgat4a)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A (MGAT4A)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A (Mgat4a)
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B L homeolog (mgat4b.L)
  • 9530018I07Rik 蛋白
  • glcNAc-T-IVa 蛋白
  • GnT-4a 蛋白
  • GNT-IV 蛋白
  • GNT-IVA 蛋白
  • mgat4a 蛋白

Protein level used designations for MGAT4A

N-acetylglucosaminyltransferase IVa , N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa , UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa , alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A , glcNAc-T IVa , UDP-GlcNAc:a-1,3-D-mannoside b-1,4-acetylglucosaminyltransferase IV , UDP-N-acetylglucosamine:alpha1,3-d-mannoside beta1,4-N-acetylglucosaminyltransferase , alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase , mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A , gnT-IVa , mannoside acetylglucosaminyltransferase 4, isoenzyme A

GENE ID SPECIES
269181 Mus musculus
11320 Homo sapiens
367252 Rattus norvegicus
282276 Bos taurus
418692 Gallus gallus
100338722 Oryctolagus cuniculus
101108820 Ovis aries
443870 Xenopus laevis
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