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The protein encoded by MCTS1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. 再加上，我们可以发Malignant T Cell Amplified Sequence 1 抗体 (86) 和 Malignant T Cell Amplified Sequence 1 试剂盒 (9)和数多这个蛋白质的别的产品。
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Hypoxia-induced MCT1 (显示 CMA1 蛋白) supports glioblastoma glycolytic phenotype, being responsible for lactate efflux and an important mediator of cell survival and aggressiveness
our finding that the expression of MCT1 (显示 CMA1 蛋白) and MCT4 (显示 SLC16A4 蛋白) is reduced in mutant IDH1 (显示 IDH1 蛋白) gliomas highlights the unusual metabolic reprogramming that occurs in mutant IDH1 (显示 IDH1 蛋白) tumors and has important implications for our understanding of these tumors and their treatment
DENR (显示 DENR 蛋白) binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1 (显示 EIF1 蛋白)/eIF2 (显示 EIF2S1 蛋白)/eIF3 (显示 EIF3A 蛋白) binding, thus operating in post-termination ribosome recycling and translation re-initiation
MCT1 (显示 CMA1 蛋白) expression, independent of transporter activity, is required for growth factor-induced tumor cell motility.
TOMM20 (显示 TOMM20 蛋白), MCT1 (显示 CMA1 蛋白), and MCT4 (显示 SLC16A4 蛋白) expression was significantly different in Hodgkin and Reed Sternberg (HRS) cells. HRS have high expression of MCT1 (显示 CMA1 蛋白), while tumor associated macrophages have absent MCT1 (显示 CMA1 蛋白) expression. Tumor-infiltrating lymphocytes have absent MCT1 (显示 CMA1 蛋白) expression. Reactive lymph nodes in contrast to cHL (显示 CHRDL1 蛋白) tumors had low TOMM20 (显示 TOMM20 蛋白), MCT1 (显示 CMA1 蛋白), and MCT4 (显示 SLC16A4 蛋白) expression in lymphocytes and macrophages.
TOMM20 (显示 TOMM20 蛋白) and MCT1 (显示 CMA1 蛋白) were highly expressed in diffuse large B-cell lymphoma lymphocytes, indicating an OXPHOS phenotype, whereas non-neoplastic lymphocytes in the control samples did not express these markers.
MCT1 (显示 CMA1 蛋白) inhibitor AZD3965 increased MCT4 (显示 SLC16A4 蛋白)-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux.
Silencing or genetic deletion of MCT1 (显示 CMA1 蛋白) in vivo inhibited migration, invasion, and spontaneous metastasis.
The reversible H(+)/lactate(-) symporter MCT1 (显示 CMA1 蛋白) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.
Reinitiation complexes involving initiation factors eIF2D (显示 EIF2D 蛋白), MCT-1 (显示 CMA1 蛋白), and DENR (显示 DENR 蛋白) controls the translation of a large fraction of mammalian cellular mRNAs.
Data indicate that monocarboxylate transporters (MCTs1-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.
This study confirmed age-dependent changes of MCT1 expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.
These findings show that MCT 1 increases with the development of rumen function and also in adult animals MCT 1 may change with the feeding.
The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.
The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.
Data suggest that expression of MCT1 in intestinal mucosa can be altered by diet; here, expression of MCT1 is down-regulated in colonic mucosa by high-protein diet and appears to be linked to fermentation of dietary proteins by intestinal microbes.
MCT1-mRNA showed a higher expression in the ileum; feeding inulin-coated butyrate resulted in an increased ileal surface; delivery of butyrate to the colon requires a more resistant inulin-coating.
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.
malignant T cell-amplified sequence 1
, malignant T-cell-amplified sequence 1
, multiple copies T-cell malignancies
, multiple copies T-cell malignancies 1
, malignant T cell amplified sequence 1
, Malignant T cell amplified sequence 1-A
, malignant T cell-amplified sequence 1-A
, malignant T-cell-amplified sequence 1-A